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[top]Introduction to Thebaine

Thebaine, also known as Paramorphine is a white, crystalline, slightly water-soluble (in pure form after a synthesis), poisonous alkaloid, with the molecular Formular: C19H21NO3,[1] present in opium in small quantities.[2] The Thebaine-Constituent of Raw-Opium is normally between 0.2% and 1.5% But higher amounts up to 6% have also been reported![3]

[top]Using of Thebaine

Thebaine is not used for therapeutic or recreational purposes, but is converted industrially into a variety of compounds including oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine and etorphine. [1]


Thebaine is metabolized via O-demethylation [1]

[top]Effects of Thebaine

Thebaine has more strychnin-like "convulsive" properties (see warnings!) rather than any narcotic effect, and possesses a sharp astringent taste and a tetanic action like strychnine.

Thebaine was long believed to have no morphine-like agonistic properties and many studies, old and recent, are supportive of this view. [3]

However, it is now evident that it has a meaningful dependence potential, both physical and psychological, when large doses are ingested over a certain period! (ie. in Poppy/ Poppyseed-tea)

[top]Different uses for Thebaine

Thebaine is used only in synthesis into other pharmaceutical drugs. People should avoid contact with thebaine itself due to the toxicity of thebaine.

[top]The Dangers of Thebaine

Thebaine is far more toxic (ten times higher) than morphine. Compared to morphine sulfate, thebaine is 10 times more lethal: Morphine sulfate anhydrous: oral rat LD50: 461 mg/kg; oral mouse LD50: 600 mg/kg!

(!) Thebaine is the most poisonous opium alkaloid!

The UNHDOC mentioned[3] that the LD. 50 of Thebaine in mice is 31 mg/kg s.c. and 20 mg/kg i.p.; other authors have reported an intraperitoneal
(the area that contains the abdominal organs.) LD 50 of 42 mg/kg in mice.

In rabbits, the intravenous LD 50 is 3-4 mg/kg and is dependent on the age of the animals. In the dog the lethal doses are reported to be 10-30 mg/kg s.c. and 5-7 mg/kg i.v.. In chicken embryo, Thebaine has been reported to induce pseudohyperfeminization (change of the Gender-features).

[top]Status in the USA

Thebaine is a controlled substance (opiate), Schedule 2. listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 [1]

[top]Status in Europe

It is controlled in Schedule II of the Controlled Substances Act as well as under international law.

Thebaine is listed as a Class A drug under the Misuse of Drugs Act 1971 in the United Kingdom [1]

[top]History of Thebaine

So called from a kind of Egyptian opium produced at Thebes. "Opium Thebacium" and Thebaine share only the origin of the name, the first is the Roman Trade-name!

[top]Further Information

Papaver bracteatum Lindl., is a Highly Rich Source of Thebaine
Papaver somniferum strain with high concentration of thebaine (and oripavine)

[top]The latest Thebaine threads

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Attached Images
File Type: jpg thebaine.jpg (48.4 KB, 651 views)
Contributors: Snouter Fancier Gold member, Alfa, Jasim Gold member
Created by Jasim Gold member, 25-04-2010 at 23:12
Last edited by Alfa, 18-11-2012 at 17:03
Last comment by NeuroChi on 11-05-2010 at 14:53
4 Comments, 33,471 Views

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