Thebaine

Contents
1Introduction to Thebaine 2Using of Thebaine 3Metabolism 4Effects of Thebaine 5Different uses for Thebaine 6The Dangers of Thebaine 7Status in the USA 8Status in Europe 9History of Thebaine 10Further Information 10.1The latest Thebaine threads 11References

Thebaine, also known as Paramorphine is a white, crystalline, slightly water-soluble (in pure form after a synthesis), poisonous alkaloid, with the molecular Formular: C19H21NO3,[1] present in opium in small quantities.[2] The Thebaine-Constituent of Raw-Opium is normally between 0.2% and 1.5% But higher amounts up to 6% have also been reported![3]

Thebaine is not used for therapeutic or recreational purposes, but is converted industrially into a variety of compounds including oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine and etorphine. [1]

Thebaine is metabolized via O-demethylation [1]

Thebaine has more strychnin-like "convulsive" properties (see warnings!) rather than any narcotic effect, and possesses a sharp astringent taste and a tetanic action like strychnine.

Thebaine was long believed to have no morphine-like agonistic properties and many studies, old and recent, are supportive of this view. [3]

However, it is now evident that it has a meaningful dependence potential, both physical and psychological, when large doses are ingested over a certain period! (ie. in Poppy/ Poppyseed-tea)

Thebaine is used only in synthesis into other pharmaceutical drugs. People should avoid contact with thebaine itself due to the toxicity of thebaine.

Thebaine is far more toxic (ten times higher) than morphine. Compared to morphine sulfate, thebaine is 10 times more lethal: Morphine sulfate anhydrous: oral rat LD50: 461 mg/kg; oral mouse LD50: 600 mg/kg!

(!) Thebaine is the most poisonous opium alkaloid!

The UNHDOC mentioned[3] that the LD. 50 of Thebaine in mice is 31 mg/kg s.c. and 20 mg/kg i.p.; other authors have reported an intraperitoneal
(the area that contains the abdominal organs.) LD 50 of 42 mg/kg in mice.

In rabbits, the intravenous LD 50 is 3-4 mg/kg and is dependent on the age of the animals. In the dog the lethal doses are reported to be 10-30 mg/kg s.c. and 5-7 mg/kg i.v.. In chicken embryo, Thebaine has been reported to induce pseudohyperfeminization (change of the Gender-features).

Thebaine is a controlled substance (opiate), Schedule 2. listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 [1]

It is controlled in Schedule II of the Controlled Substances Act as well as under international law.

Thebaine is listed as a Class A drug under the Misuse of Drugs Act 1971 in the United Kingdom [1]

So called from a kind of Egyptian opium produced at Thebes. "Opium Thebacium" and Thebaine share only the origin of the name, the first is the Roman Trade-name!

Papaver bracteatum Lindl., is a Highly Rich Source of Thebaine
Papaver somniferum strain with high concentration of thebaine (and oripavine)

[top]The latest Thebaine threads

Article / Page Starter	Last Post	Comments	Views
Dose - Advice For Combining Benzos+Oxycodone stasik	24-05-2013 22:08 by baZING	3	57
Drug info - Back/Neck Pain Management country_man	24-05-2013 20:48 by RichInMethadonia	10	153
Effects - tramadol and hydrocodone. new_91	24-05-2013 06:09 by new_91	0	34
Drug info - Shelf life of Pethidine(Demarol)? southey	23-05-2013 22:40 by RichInMethadonia	3	96
Snorting TRAMadol Garagehousenation666	23-05-2013 02:41 by Smeg	12	13,866
Side effects - I LOVE to read, and i LOVE to use opioids, but i also can't see! babalooj	22-05-2013 16:50 by babalooj	0	58
Injecting - Red welts and dots immediately after injection NavajoPoppyLover	20-05-2013 21:21 by headfull0fstars	3	112
Combinations - Best Opiate to mix with Phenazepam (Not restricted to Opiates) CubsGuy17	19-05-2013 23:54 by DiabolicScheme	8	247
Dose - w-18 1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide drewpy	19-05-2013 22:37 by quickiB	1	208
Complete List of Opioid Dosages ( 1 2 3 ... Last Page) PandorymDMT	19-05-2013 17:04 by drewpy	212	144,632

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Thebaine

Contents

[top]Introduction to Thebaine

[top]Using of Thebaine

[top]Metabolism

[top]Effects of Thebaine

[top]Different uses for Thebaine

[top]The Dangers of Thebaine

[top]Status in the USA

[top]Status in Europe

[top]History of Thebaine

[top]Further Information

[top]The latest Thebaine threads

[top]References

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