Plugging is a route of administration for drugs
in which the user puts the drugs in their rectum which results in faster absorption through the mucous membrane of the rectum and lower intestine. First pass metabolism is also partially bypassed which may allow for lower dosage administration than taking by mouth.
Plugging is an especially effective method of consuming drugs with low oral and/or intranasal
bioavailability; however, the dose must be lowered accordingly compared to the dose needed for those routes-- about half the dose needed for oral is a good benchmark for plugging a new substance. Individual reactions may vary.
A very common way of doing this is by mixing your drug
in some water and placing it in a well-lubricated oral syringe, then shooting the water up the rectum and laying around on the left side until the desired effects kick in.
Plugging makes the effects of a drug kick in faster and have been reported of lasting longer, though this is not always the case. Though this method is not particularly common, it is a viable and effective route of administration for many drugs. It is much safer than IV/IM/SC injection and may be used as an alternative.