The arylcyclohexylamines light up too many of the reward systems in the brain, with the dopamine
-reuptake inhibition, the NMDA antagonism, and the µ-opioid
affinity. They lend themselves to abuse and escape to fantasy
High instances of significant urge to redose (fiending) reported anecdotally.
"Somebody in Sweden injected 100 mg of methoxetamine and 400 mg of MDAI
... there were cardiac problems, and the person died."
Anecdotal reports suggest that it has similar psychological addictive tendencies as ketamine for some people, but the longer duration probably means that the 'fiending' may be less intense.
With repeated use, the effects get less euphoric and anxiety increases. From the records of those taking the ketamine daily, one might expect that the a simulation of paranoid schizophrenia might might occur.
Methoxetamine, like all psychologically psychoactive
drugs, has the propensity to induce panic and/or anxiety attacks. This is largely dose dependent and therefore users must familiarise themselves with lower doses before attempting high doses.
Obviously people with conditions such as schizophrenia should stay away from this compound.
it [Methoxetamine] has a dose low enough that it should not harm the urinary bladder like Ketamine.
Taking care when redosing is of great importance. The reason for this will be illustrated a bit more graphically:
~t+0.20 for the peak to begin
~t+2.00 for the peak to end
~t+4.00 for the after effects to pretty much end.
The after effects take a very very long time to wear off and they are not insignificant effects by any means. Even 30 mins after the peak has 'ended', the effects may still be 70-80% as strong as they were during the peak. This means that redosing 10mg on a 50mg trip at this point will bring the experience right back up to the intensity it had been during the peak. Just from 10mg - and taking 20 mg would bring an, albeit, short, peak back but even higher than it had been during the first peak! After already experiencing a significant 2 hour peak, this can be quite unexpected and unwanted.
the ^ represents a dosage taken
the @ represents the level of effects felt as its equivalent in mg for a certain time.
This is approximate, but should give a good idea.
|^50mg||@50mg||@50mg||^30mg||@80mg||@70mg||@60mg||@50mg||@35mg||@20mg||@10mg||mild after effects||very mild after effects|
|^50mg||@50mg||^30mg||@80mg||@80mg||^20mg||@90mg||@75mg||@60mg||@45mg||@25mg||@10mg||mild after effects|
In the above table, a reasonably large dose is started with- the main dose- and this is supplemented with smaller doses (although not quite small enough- 30 is a large re-dose). Even so, you can see that over time they stack up and cause 1 hour long 80mg experiences which is seriously high (not to be attempted by unexperienced users).
|^50mg||@50mg||^40mg||@90mg||@90mg||^40mg||@120mg||@105mg||@90mg||@75mg||@60mg||@45mg||@30mg||@15mg||mild after effects|
The table above demonstrates an experience with higher redoses. Note with high dosages that the experience can last longer, especially the after effects. Even though the last dosage was taken at t+2.30, the effects continue until t+7.00. Even though they are mild at that point, see that even at the 5 hour mark the effects are on 60mg- still a significant dose and after tripping for so long, it can start to take its toll. Note also that the increments cause a peak of 120mg, which is seriously high (not to be attempted unless seriously experienced), and lessens very very slowly.
|^30mg||@30mg||@30mg||^10mg||@50mg||^10mg||@50mg||@40mg||@30mg||@10mg||mild after effects|| || |
The above table represents an 'ideal' approach to redosing for unexperienced users. The main dose is started with, and then low redoses are taken (if desired- redosing is of course not a must, just something often done).
Because of the long duration of methoxetamine, not appreciating the cumulative effects of redosing can result in an experience which is too intense. Furthermore, as Methoxetamine does not inhibit movement as much as ketamine, hurting yourself during freak-outs is especially dangerous. Additionally, whereas on ketamine you can look forward to coming down fast, on methoxetamine, especially high doses, the return to baseline is long and arduous.
There has been a published case study of three methoxeamine "overdoses" presenting at a hospital in the UK. The amounts that the users reported taking were 500mg, 200mg and unknown. In the case of the unknown dose, testing of biological fluids revealed a Serum methoxetamine
concentration of 0.20mg/l, compared to the 0.12mg/l found in the patient who took 500mg.
Adverse symptoms common to all cases were:
- tachycardia ranging from 113-135BPM
- Hypertension (187/83 mmHg, 201/104 mmHg and 198/78 mmHg)
- dilated pupils
This suggests sympathomimetic toxicity in high/overdoses. All 3 were treated with benzodiazepines, and suffered no lasting effects
Overdosing on Methoxetamine in the sense of taking so much that negative effects occur can happen. A person might:
-forget they have taken the drug
-become preoccupied with delusions, possibly dangerous ones
-lose all sense of time, reality and self
-become fearful, or panic
-think they have gone insane
In these situations, if a person is experiencing some of these negative psychological symptoms, you must reassure them. Tell them that they have taken a drug, that these are all just effects of the drug and that they WILL end. It can take several hours- but there is a gradual process of re-entry during that time where they will gain more and more awareness. Vomiting a bit is normal. You may have to constantly reassure them, but keep doing it. It might be frightening for you to see someone in such a state, but know that it is purely drug induced- it's your job to simply help them wait for the effects to wear off.