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[top]Introduction to Methoxetamine

Methoxetamine is a dissociative drug which has effects similar to but different than that of ketamine. Methoxetamine also differs greatly in terms of dosage when compared to ketamine, often time requiring a much smaller dose to reach ones desirable effects. As a dissociative drug, methoxetamine has an interesting mechanism of action, acting both as an NMDA receptor antagonist (like many dissociative drugs) and a serotonin reuptake inhibitor, both of which contribute to the overall effects of the compound. Methoxetamine is a research chemical, designed as an alternative, cleaner version of ketamine, though this has yet to be formally proven through legitimate clinical trials. The duration for which methoxetamine acts when compared to ketamine is significantly longer (3-4 times the duration), this is due partially to the compounds N-ethyl group was chosen to increase its potency.

[top]Using Methoxetamine

[top]Ways of Administration

Methoxetamine can be administered through a variety of different routes including oral consumption, intranasal insufflation, intramuscular injection, intravenous injection, sublingual/buccal absorption and rectal administration. Each route differs from one another in terms of the compounds time of onset, potency, and duration.

[top]Effects of Methoxetamine


  • Mild to moderate euphoria
  • Antidepressant type effects persisting for up to several days
  • Pronounced feeling of calmness
  • Anxiolysis (reduction in anxiety)
  • Increase in ability to socialize (lower doses)
  • Therapeutic self-reflection
  • Insight into personal issues including behavior and thinking patterns
  • Increase in clarity, detail, and/or complexity of thoughts
  • Spontaneous and vivid recall of latent memories during or after peak effects


  • Dissociation (separation between mind and body)
  • Closed or open eyed visual hallucinations
  • Loss of intensity and/or clarity of sensory inputs
  • Loss of coordination (increasing with dose)
  • Slurring of words
  • Mild stimulation or body load
  • Insomnia
  • Time distortion
  • Increased introversion or extraversion
  • Sensation of floating
  • Hallucinations (Affecting all five senses)
  • Sweating
  • Urge to redose


  • Short-term memory impairment, gradually resolving with abstinence
  • Paradoxical impairment of language processing including difficulty in finding the correct words to describe thoughts (may last for up to several days)
  • Possible increase in anxiety
  • Distressing or unwanted thoughts or insights
  • Grandiose thinking, or feeling more competent to control or achieve things than one actually is
  • Reduction in quality of sleep immediately following use
  • Risk of psychological dependency; risk may be greater for introverted people
  • Disorganized thoughts
  • Catatonia (high doses)
  • Blackouts (high doses)
  • Respiratory depression (high doses & when combined with other CNS depressants)
  • Death (overdose)
  • Time before onset and intensity of effects from a given dose may vary significantly between separate sessions (poorly understood)

[top]Dosing Methoxetamine

[top]Combinations with Methoxetamine

Methoxetamine is a very sensitive substance on its own, let alone when combined with other drugs. Methoxetamine is known to potentiate and/or produce excessive synergy when combined with certain substances, resulting in overdose and sometimes even death.
  • Cannabinoids both natural and synthetic have been known to cause uncomfortable negative side effects when combined with methoxetamine.
  • Central nervous system depressants should be avoided when administering methoxetamine, as dangerous synergistic effects may result due to the combination between the two substances.
  • Central nervous system stimulants should be avoided when administering methoxetamine, as the outcome tends to prove uncomfortable for the user.
  • Serotonergic substance should also be avoided when administering methoxetamine, as there may be a danger of serotonin neurotoxicity to occur.
  • Methoxetamine is considered to be a research chemical, thus the effects and side effects have yet to be fully establish through clinical trials, and very much likely will differ from user to user.

[top]Different Uses for Methoxetamine

[top]Pharmacology of Methoxetamine

Mechanism of actionNMDA antagonism, Serotonin reuptake inhibition
Routes of administrationOral, Sublingual, Buccal, IM, IV, Rectal
Half-Life3-6 hours
CNS activitySlight depression

[top]Chemistry of Methoxetamine

Methoxetamine is a member of the arylcyclohexylamine family, more specifically a derivative of ketamine, where the 2-chloro group on the phenyl ring is replaced by a 3-methoxy group, and the N-methyl group on the amine is replaced with a N-ethyl group.

Systematic(IUPAC) name:2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone
Synonyms:Methoxetamine, MXE, 3-MeO-2-Oxo-PCE
Molecular Formula:C15H21NO2
Molar mass:247.33 g/mol
CAS Registry Number:1239943-76-0
Melting Point:no data
Boiling Point:no data
Flash Point:no data
Solubility:no data
Additionnal data:none

Like many dissociative drugs methoxetamine is a chemical of the arylcyclohexylamine class, other chemicals in this class can be found in the table below.

Methoxetamine 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone
Ketamine 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone

[top]The Dangers of Methoxetamine

[top]Physical Health Risks

[top]<Physical Problem 1 - Please Identify and Add Others As Necessary>

[top]<Physical Problem 2 - Please Identify and Add Others As Necessary>


[top]Reported Deaths

[top]Mental Health Risks

[top]<Mental Health Risk 1 - Please Identify and Add Others As Necessary>

[top]<Mental Health Risk 2 - Please Identify and Add Others As Necessary>

[top]Side Effects


[top]Physical Addiction

[top]Mental Addiction

[top]Producing/Growing Methoxetamine

[top]Forms of Methoxetamine

[top]Legal Status of Methoxetamine

[top]United Nations


Federally methoxetamine is not considered to be an illegal substance as the analogue act only applies to schedule I and II drugs. With ketamine being a schedule III, methoxetamine would not be an illegal analogue of ketamine, however it may be treated as an analog of PCE which is a schedule I substance in the United States, thus the federal analog act would then apply.


[top]Other Countries

[top]History of Methoxetamine

[top]More Methoxetamine Sections

[top]The Latest Methoxetamine Threads

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  1. ^ Interview With a ketamine chemist
  2. ^ Interview With a ketamine chemist

[1]Merck Index, fifteenth edition (2013)

Created by Joe-(5-HTP), 12-02-2011 at 12:45
Last edited by syntheticdave, 07-04-2014 at 17:48
Last comment by syntheticdave on 10-04-2014 at 04:26
5 Comments, 151,113 Views

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