The compound appears to typically be used analogously to other recreational
stimulants in a wide variety of settings - from large
social groups to isolation. Though reports exist for a number of different methods of administration, mephedrone appears to be most commonly ingested orally and intranasally. Some individuals consider the compound to be strictly stimulant in effect, while many observe pseudo-
psychedelic visual and auditory distortion.
[top]Routes of administration
Taking a fixed amount orally can help limit the common urge to redose and prevent excess use.
Oral doses can be taken in a variety of ways; the easiest being either mixed with water, or wrapped in a rizzla paper and swallowed.
First time doses should range between 100mg and 150mg and users are advised to try to avoid eating for a few hours before administration as this can dampen the effects.
"250mg is a good oral dose, but the tail end effects will last a lot longer and sleep will be difficult."
A dose of 150mg-250mg is the average, giving a duration of around 2 hours.
Oral doses last longer but also take longer at onset; it is important not to redose early even if users feel it has not affected them. When using a gel capsule, onset of effects can take up to 45 minutes to be felt.
Side-effects from oral dosages can be nausea, stomach cramps and vomiting (especially in larger 250mg+ dosages).
[top]Insufflation
Insufflating mephedrone can dramatically increase the urge to redose, therefore it is important users set out a maximum amount for the night and stick to it.
First time doses should range between 25-75mg and can take up to 15 minutes to start working. Crushing/chopping the powder as finely as possible and placing a straw well inside the nostril before
snorting can greatly increase the effects.
Many people consider snorting to be a dangerous method of administration; especially for
drugs which are active when taken orally, due to increased risk of nose damage. Side-effects from snorting seem to be worse when compared to taking the same total dose orally - it's "harsh" on the body.
It's recommended to not share straws/notes with other people as this can increase the risk of infection. This is particularly important with mephedrone, as nose bleeds and nasal sores are a common complaint compared with many other drugs taken via this route.
[top]Intravenous
Administering intravenous mephedrone is extremely dangerous, and highly enhances the potential for dangerous side-effects. Both sample purity and handling are important factors to consider. Additionally, the drug is observed to be quite addictive by individuals favoring oral and
intranasal routes; the addictive components of the effects of the drug are likely to be quite higher, and may compel users to pursue dangerously high levels.
Doses for IV administration of 4-MMC range widely, and have been observed to range from 40mg to approximately 500mg.
Rectal administration, otherwise referred to as '
plugging', is characterized by a faster onset relative to oral dosing, requires lower doses, and has been suggested to be characterized as having a more rapid termination of activity relative to oral doses. A dose of 100 mg has been observed to last approximately 20 minutes, but this is quite likely variable between individuals.
Two general methods include the use of a syringe (needle removed) with 200 mg in fewer than 10 mL of water (approaching 5 mL) inserted while lying prone, allowing the solution to absorb over 3-5 min - as well as the use of gelatin caps as a vehicle for the compound to be inserted.
Rectal (plugging) administration of mephedrone
Mephedrone capsule...inserted anally?
[top]Effects of Mephedrone
The primary effects tend to reflect those of sympathomimetic stimulants such as amphetamines,
cocaine, or
MDMA. There appears to be a distinct
euphoria and sociability inspired by the compound, as well as a strong urge to ingest large quantities subsequent to initial administration. Recreational doses induce transient anorexia, and appear to affect cardiac activity in typical CNS stimulant patterns.
The after-effects, or 'come-down' associated with mephedrone - occurring immediately subsequent to the duration of effects of the compound - is highly variable, but commonly consists of overall behavioral sedation and a desire to ingest more. There indeed appears to be an effect upon mood that reflects those of other recreational psychomotor stimulants such as cocaine or methamphetamine; individuals report 'come-downs' along a range of severity, from mild depression and languid disposition to intense depression. There is discussion of a transient suppression of immune system function, as many observe short periods of illness subsequent to ingestions of over 500 mg.
Side-effects are similarly variable, and include reactions as mild as persistently raised heart rate to severe - such as seizures and a bluing, or apparent bruising, of extremities. Other side-effects include difficulties with memory, persistently low body-temperature, anhedonia, and chest pain.
Mephedrone Experiences & Side-Effects Database
Very grumpy when mephedrone wears off?
Mephedrone comedown or just from sleep deprivation?
Cross Tolerance Mephedrone, Methylone and Ecstasy
[top]Combinations with Mephedrone
Posting Rules
