[top]Habituation/addiction
MDPV is a dopamine re-uptake inhibitor, and increases the level of dopamine in the synaptic cleft of neurons which it affects. Drugs which increase synaptic dopamine in the ventral striatum are often psychologically habituating. MDPV has been described as "strongly habituating".
Quotes from DF members regarding MDPV's habituating properties:
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"MDPV is like the bastard with a whip you've got to obey or you get hurt. Then you obey and get hurt even worse. Finally, it's "Thank you sir may I have another... thank you sir, may I have another... thank you sir, may I have another..." and you wonder why you've come to enjoy feeling like shit nearly every waking moment. You vow never to touch MDPV again, then an hour or two after it wears off you find yourself eagerly using MDPV."
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"MDPV is by far the most addictive in the sense of cravings etc of everything coming under the 'RC' heading."
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"MDPV is the most compulsive drug swim has ever done, he just can't stop hitting that pipe, it's worse than fucking crack! He's been at it since 11am, 16 hours ago, and in that time he's done 150mg so far, solely via the pipe, far too much!! He's still got over 300mg left, aargh!!! ...He's not even sure if he's still enjoying it, don't think he is, but still he can't stop hitting that pipe for some reason (though he does know why really, dopamine = reward innit). Bloody strange substance! Any swimer fancy coming round and freeing swim of this bloody pipe?"
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"1 gram. 6 days. 0 sleep. 0 food. 2 12oz bottles of water. Severe Dehydration (Cracked and blistered lips, sores in the mouth, sore throat). Stimulant Psychosis. He thought his limbs weren't getting enough oxygen and turning purple. Even after other sober monkeys re-assured him that he was OK, he was convinced he was losing his limbs. Complete defeat and surrender to that drug. Poor poor monkey. SWIY can be one of those people who reads all the comments about how insane this drug is, that it produces extreme anxiety and paranoia, and yet you go back RELENTLESSLY...and you can think to yourself 'Nah, SWIY knows when to stop, SWIY can have a gram on him/her and only dabble in a mg or 2 every now and then. And besides, if the side-effects are so bad SWIY won't want to do any more and stop.' You can think that. But you're most likely very wrong. MDPV is brutal, not fun, and strangely powerful."
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Some routes of administration may be safer than other. There is general agreement that oral or sublingual dosing is less likely to lead to binging, habituation, and overdose than smoking. However, even with moderate oral use, one user reported a worrisome pattern of gradually increasing tolerance and increasing dose size, and the beginnings of obsessive thoughts about the drug:
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"SWIM has found some fiending with this chem. Surprise, surprise. SWIM & MDPV get along together a little too well. Orally, a single daily dose around 6mg is the sweet spot. Tons of energy and mood elevation for several hours. Really comes in handy for getting things done. However, SWIM is now finding a moderately strong impulse to use MDPV almost daily, as an adjunct to strong coffee during the day. SWIM's brain is finding it difficult to NOT THINK about the MDPV. All those neatly folded packages stored away, conveniently pre-weighed at 6mg amounts... they're calling SWIM. "Yoo hoo!", they playfully taunt. SWIM has even gotten used to the horrible bitter taste from dosing, and easily recognizes the stages of MDPV absorption, relishing the various physiological and mental effects."
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[top]Sympathetic over-stimulation
MDPV inhibits re-uptake of dopamine and norepinephrine. Both of these substances are neurotransmitters in the sympathetic neurons of the autonomic nervous system, and both also have direct effects on other tissues, such as blood vessels and the heart. Toxic side-effects of NDRI substances reflect over-activity of the sympathetic nervous system. Symptoms include tachycardia, hypertension, diaphoresis, and anxiety, sometimes extreme. In serious overdose, anxiety can progress to frank psychosis.
Even at normal recreational doses, moderate tachycardia is common. This tachycardia is noticed to increase with even mild exertion.
There is general agreement that the line between pleasure and pain is narrow with MDPV. The user who is successful with a low dose is inclined to push the dose higher in search of more euphoria, and will at some point hit toxic levels, often without warning.
Panic attacks are common. New users frequently believe, after having used MDPV a few times, that they have learned to use the drug safely, and the first panic attack can come unexpectedly.
Descriptions of MDPV toxic effects by DF members:
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"SWIM feels that MDPV is not as friendly as other stims. It is too dose sensitive when it comes to catacholamines. With cocaine or speed, SWIM can push the euphoria way higher with repeated use, but with MDPV, hitting that magic 8mg creates a super unpleasant state of of extreme tachycardia (160-180bpm), sweating, dizziness, numbness of extremities, rapid and weak peripheral pulses with dropped beats, extreme overstimulation, shakes and confusion. This translates to SWIM as 'about to overdose and flop like a fish'."
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[From a report of vivid visual hallucinations and delusions during a three day binge of insufflating MDPV] "I would experience extremely releastic hallucinations thoughs, thinking a draw full of plain t-shirts was all colourful t-shirts and thinking somebody had just muddled up and put them in the wrong draw... thinking I was sharing a room with people, believing I was sleeping on the street as part of a project, thinking I had woken up in the future, seeing a midget climb my shelves, see a cat in a santa outfit, birds on my window ceil made of tinsil, actually talking to someone who I thought I was sleeping on my floor........ all really wierd stuff but it seemed perfectly plausable at the time and made sense."
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"Monkey has never experienced full blown paranoid psychosis like he is from his recent MDPV binge (both with nights of sleep and nights without). He took the dosages way to far, (shamefully) admitting an excessive amount administered intravenously. Monkey developed a temporary psychotic state – which he is currently at the tail end of – where every night he thought people were outside of his apartment that wanted to extort him for everything he owned and possibly kill / beat him to death... This is the only drug that has ever caused temporary psychosis for monkey. Let this be a warning to all other primates."
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One user reported "auditory hallucinations of a particularly catlike-mewling nature."
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"[ROA were] IM, IV and vaporizing. Suddenly 15 mg a night became hundreds, towards the end easily a gram in 24 hours. Remarkably there were no major physical side effects besides vasoconstriction, a dirty feeling in the hair and skin, fatigue, tachycardia and jumpiness; BUT psychologically it had the most unique and destructive effects of any drug except maybe freebase cocaine (which in MSBF's mind is the more benign of the two - psychologically that it). These binges would last from 3-9 days with nonstop nightly use (every few minutes) and a hiatus during the day with hourly bumps to let the tolerance go down. MDPV tolerance short term kicks in very fast which is why you can use such vast amounts and survive. There are two effects - at a low dose it is a ritalin like stimulant. At high doses the stimulation hits a plateau very quickly and wears off hours after use, but a new effect takes over - a combination paranoid, psychedelic, deleriant, nyphomaniac effect for lack of a better way to describe it... The paranoia from this is akin to that of day 7 of a methamphetamine binge with delusions of being followed, hearing voices and footsteps around the corner, seeing people in the room with MSBF, and elaborate conspiracy plots in MSBF’s head. MSBF has been convinced of being robbed of MDPV, searched the carpet for hours to find lost crumbs of powder, was sure of being followed, thinking there was construction going on outside of the bedroom door, family plotting an intervention, etc... MSBF would only stop a binge when MSBF started to get delusionally paranoid, and the comedown was the worst of anything ever. It lasts about a month with the first few days being like a detox. Nausea, vomiting, dizzy spells, inability to exercise, extreme fatigue to the point of falling asleep standing up mid sentence, and an unrelenting depression, mood swings, tremors and anhedonia. The almost narcoleptic like fatigue, depression, mood swings, anhedonia, and inability to exercise last about a month after stopping but then MSBF seems to have gone back to normal after that with no lingering effects other than a temptation to use it again. MSBF rarely disposes of drugs, but gratefully flushed the last 8 grams of this stuff down the sink many months ago, along with throwing away all paraphernalia associated with it."
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[top]Other adverse effects
[top]Abdominal pain
Complaints of abdominal pain in MDPV users are common.] The pain may be minor, but there have been reports of severe pain and vomiting blood. Although the underlying pathology is not known with certainty, H2 blockers have been reported to help, which suggests that gastritis, esophagitis, or peptic ulcer might be the cause. Domperidone/Motilium has also been recomended for this symptom.
[top]Rhabdomyolysis and kidney damage
Rhabdomyolysis is muscle breakdown. When muscle is damaged, proteins such as myoglobin are released into the bloodstream in large amounts. In severe rhabdomyolysis, these proteins can damage the kidneys. Often this damage is reversible, but in severe cases, permanent kidney damage or even kidney failure may result.
One user reported elevated creatine kinase levels after a three-day MDPV binge (creatine kinase is a measure of muscle damage). Another user reported 'mild kidney dysfunction'. . He attributed it to concurrent use of ' poppers' and resulting hemolysis, but MDPV-related rhabdomyolysis may also have been a contributing factor.
It has been theorized, though never proven, that rhabodomyolysis in stimulant users is caused by dehydration, and preemptive vigorous oral hydration is therefore often advised.
[top]Movement disorders
Transient symptoms suggestive of Parkinson's Disease have been reported during MDPV use. These are descriptions from reports:
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"i aslo feel it has an effect on some cerebellum / spatial coordination / balance-related structures as there is noted peripheral jerkiness to movements and a lesser perceived but still noted decrease in hand-eye coordination, which, if left unmitigated, with prolonged use becomes rather severe."
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"[SWIM] could not master the rapid rhythm of touch-typing. It seemed to be due to a curious inability to initiate movement: a finger would pause before hitting a key until SWIM consciously forced it to strike the key. Now, difficulty initiating movement is one of the cardinal signs of Parkinson's disease...SWIM didn't have any of the other signs of Parkinsonism, and had no gait problems, no fine motor problems (handwriting was normal), but still, this was a very disturbin' development...Thankfully, the symptom went away in the next 24 hours, and SWIM's typing has been back to normal since. SWIM still thinks it was some sort of dopamine-depletion phenomenon."
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"...hand writing is like parkisonian patients ! People if you get blurry vision and that your hand writing does not look like yours (very tiny, unreadable almost), if you keep pushing, you are almost 100% sure to fall into psychosis..."
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One user with similar symptoms was hospitalized with a suspected stroke. However, the symptoms resolved.
DF has no reports of long-term Parkinsonian symptoms related to MDPV use. Thus far, these symptoms appear to be self-limited. However, sub-clinical damage to movement centers in the substania niagra that may not emerge until much later cannot be excluded.
[top]Long-term cognitive changes
One DF member reports MDPV causes long-term changes in cognition and emotional stability and "permanent reorientation of the reward circuitry value systems."
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