[top]Ways of Administration
Fluoxetine is available in immediate-release capsules and tablets in dosages of 10, 20, and 40 mg, a delayed-release capsule containing 90 mg fluoxetine in enteric-coated pellets (Prozac Weekly,) and an oral solution containing 20 mg fluoxetine/5 ml.
[top]Effects of Fluoxetine
As with other antidepressants
, fluoxetine may take 2 or more weeks to produce a noticeable effect; single doses have minimal utility. Fluoxetine's psychoactive
effects are usually subtle; euphoria
and CNS stimulation or depression are estimated to occur in 1/100-1/1000 patients and thus the drug
is considered to have minimal recreational potential. Emotional blunting, an inability to feel extreme emotions of any kind, is often reported.
There is controversy regarding the efficacy of fluoxetine and other SSRIs; in some clinical trials there is little to no statistically significant difference between the effects of fluoxetine and a placebo.
[top]Combinations with Fluoxetine
Fluoxetine is commercially available in combination with the 2nd-generation antipsychotic olanzapine, as Symbyax, for depressive episodes of bipolar disorder. Symbyax contains either 6 or 12 mg olanzapine with either 25 or 50 mg fluoxetine.
[top]Different Uses for Fluoxetine
In the U.S., fluoxetine is approved for major depressive disorder, obsessive-compulsive disorder, bulimia nervosa, and panic disorder alone and with agoraphobia, and premenstrual dysphoric disorder, and sometimes prescribed off-label for selective mutism, post-traumatic stress disorder (PTSD), social anxiety disorder, chronic neuropathic pain, fibromyalgia, and Raynaud's phenomenon.