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[top]Introduction to Ethylphenidate


Ethylphenidate is a recent research chemical introduced in 2011. Not much is known about it at this moment. It is a potent psychostimulant that acts as both a dopamine reuptake inhibitor and norepinephrine reuptake inhibitor.

Anecdotal evidence suggests it is actually more active as a dopamine reuptake inhibitor than norepinephrine. This produces a less jittery and more euphoric high than methylphenidate (or even cocaine).[1]

Users report a a duration of 1.5 to 3 hours and it comes on almost as quickly as cocaine does (around 5 mins after snorting). The need to re-dose is debatable and probably specific from person to person.

Most information is derived from the Drugs-Forum Ethylphenidate Drug Information thread[2], wikipedia and other fora.


[top]Using Ethylphenidate

[top]Ways of Administration

[top]Intranasal

Ethylphenidate can be in insufflated although users report this is a painful experience. Rinsing the nose is recommended.

Wikipedia has information from another drug related forum stating that damage of perforated septum after fairly low usage. I use this route and flush my nose about 20 minutes later by snorting water from a spoon repeatedly until I feel the pathway is clear. But with this added information, and dosages and effects not much different from sublingually, it is, now the most likely next safest route.

Dosages:
25mg - weak
25-50mg -mild
50-75mg - strong
100mg - very strong

[top]Oral

Dosages are probably comparable to Intranasal route

[top]IV


Ethylphenidate can be injected by dissolving it in water. The dosages are probably a lot lower than other routes. As always injecting is very dangerous and not advised unless the user is absolutely sure about what they're doing.

Intramuscular injection (IM) of ethylphenidate is also possble. The same cautions apply as with IV.

[top]Effects of Ethylphenidate

Although classified as a potent psychoactive stimulant, it has been reported to be more euphoric than other stimulants and some users describe it having less side-effects.

[top]Main effects

  • Increased conversation
  • Abstract thinking
  • Euphoria
  • Some stimulation but not like with cocaine or methylphenidate
  • Increased music appreciation
  • Warm fuzzy body high

[top]side effects

  • Jaw tension
  • Anxiety
  • Penis shrinkage
  • Restlessness
  • Inability to concentrate on one task
  • Slight stomach discomfort from oral dosages which could be when taken at the same time as food.

[top]after effects

  • Slight comedown
  • Possibility to re-dose. More so at higher doses, although a tolerance builds up quickly if not much time is left between each dose or the dose is high.

[top]Combinations with Ethylphenidate

[top]Different Uses for Ethylphenidate

  • Stimulant
  • Anti-depressant
  • ADHD treatment (?)


[top]Pharmacology of Ethylphenidate

Ethylphenidate is the ethyl ester of 2-phenyl-2-(2-piperidyl)acetic acid, in the similar manner that methylphenidate is the methyl ester.

The following is a 3D model of the chemical bond.

[top]In Vivo formation of Ethylphenidate


Most research has been done around the in vivo creation of ethylphenidate by mixing alcohol with methylphenidate.[3] Since the synthetic formulation is novel it is interesting to research the difference between the two ways of experiencing ethylphenidate in the human body.


[top]Chemistry of Ethylphenidate

Ethylphenidate is a structural relative of the chemical Methylphenidate. It can be produced by Methylphenidate HCl hydrolyzed to ritalinic acid, and subsequently esterify to ethylphenidate with ethanol HCl.



Systematic(IUPAC) name:(RS)-ethyl 2-phenyl-2-piperidin-2-ylacetate
Synonyms:2-phenyl-2-(2-piperidyl)acetic acid, 2-Piperidineacetic acid, alpha-phenyl-, ethyl ester
Molecular Formula:C15H21NO2
Molar mass:247.33274 g/mol
CAS Registry Number:57413-43-1
Melting Point:** ℃+pressure if applicable
Boiling Point:** ℃+pressure if applicable
Flash Point:** ℃+pressure if applicable
Solubility:**pharmacopeia style


[top]The Dangers of Ethylphenidate

  • Potentially similar to methylphenidate

[top]Physical Health Risks

[top]<Physical Problem 1 - Please Identify and Add Others As Necessary>

[top]<Physical Problem 2 - Please Identify and Add Others As Necessary>

[top]Overdose

[top]Reported Deaths

[top]Mental Health Risks

After high dosages or repeated redoses and lack of sleep the anxiety, although not overwhelming, can leave a person rather jittery and may find the most simple of tasks much more taxing than it is.

Getting plenty of food before and after can help relieve some of the jitters.

[top]<Mental Health Risk 1 - Please Identify and Add Others As Necessary>

[top]<Mental Health Risk 2 - Please Identify and Add Others As Necessary>

[top]Side Effects

[top]Addiction

[top]Physical Addiction

[top]Mental Addiction



[top]Producing/Growing Ethylphenidate



[top]Forms of Ethylphenidate

  • Crystallized shards
  • White Powder


[top]Legal Status of Ethylphenidate

[top]USA


Although it is claimed to be legal, it may be considered to be an analog of the Schedule II controlled substance, methylphenidate. [4]

[top]EU

  • UK: Unscheduled
  • D: Unscheduled

[top]Other Countries

  • CAN: Unscheduled
  • UN: Unscheduled


[top]History of Ethylphenidate

This compound only has a very brief history of widespread use, and unfortunately no absolute facts are known about the potential dangers/toxicity that may arise from the recreational abuse/use of ethylphenidate to date.

Most information that is available is about the metabolism of methylphenidate with alcohol into ethylphenidate in the liver. It is however questionable whether the effects are truly the same. Users have reported the contrary, and that it's rather a drug of a class in its own.

It is said to have appeared on the RC market in Dec 2010.



[top]The Latest Ethylphenidate Threads


  Article / Page Starter Last Post Comments Views
electricvelvet
23-04-2014 05:45
by monkeyking Go to last post
5 337
Hollowbin
21-04-2014 19:05
by Hollowbin Go to last post
2 105
Missedflop
21-04-2014 01:40
by Thepsychonaut Go to last post
28 3,305
mandy23
18-04-2014 05:17
by Lady Codone Go to last post
5 637
davestate
17-04-2014 15:21
by Raskolnikov Go to last post
177 127,216
uncle_bud
17-04-2014 14:00
by dr ACE Go to last post
3 209
fro5529
17-04-2014 10:06
by benzopiated Go to last post
3 386
Joel2k11
13-04-2014 04:10
by MenTal_PaTienT Go to last post
3 3,073
psychedelaholic
08-04-2014 23:54
by (NS)-M-Lo-Reason Go to last post
7 12,199
bigsleep
06-04-2014 09:04
by bigsleep Go to last post
0 150


[top]References

  1. ^ Williard, R.; Middaugh, L.; Zhu, H.; Patrick, K. (2007). "Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity". Behavioural Pharmacology 18 (1): 39–51 PMID 17218796
  2. ^ http://www.drugs-forum.com/forum/sho...ixzz1iqgU4vTFv
  3. ^ J. Markowitz, C. DeVane, D. Boulton, Z. Nahas, S. Risch, F. Diamond, and K. Patrick, “Ethylphenidate formation in human subjects after the administration of a single dose of methylphenidate and ethanol.,” Drug Metab Dispos, vol. 28, no. 6, pp. 620–4, 2000.
  4. ^ Williard, R.; Middaugh, L.; Zhu, H.; Patrick, K. (2007). "Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity". Behavioural pharmacology 18 (1): 39–51 PMID 17218796


Attached Images
File Type: png 500px-Ethylphenidate.svg.png (16.4 KB, 20 views)
File Type: jpg synthesis.jpg (18.7 KB, 3226 views)
Attached Files
File Type: pdf mj8-2_58-61.pdf (884.7 KB, 26 views)
Created by nemo, 08-01-2012 at 07:59
Last edited by enquirewithin , 13-07-2012 at 16:14
Last comment by bhonkers on 12-10-2013 at 21:11
9 Comments, 89,315 Views

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