[top]Ways of administration
Cyclizine's most common routes of administration are orally, intravenously and intramuscularly. It can also been injected subcutaneously. It must be in the right form to be injected, either sold as an injectable preparation or as pills that can be made into solution. Some pills gel up when added to water and cannot be injected. It can be combined with injectable opiates as a strong opiate booster in doses of 25-100mg or orally at 50-200mg.
Taken orally as a deliriant/hallucinogen
much larger doses are needed however some users require relatively low doses to achieve visual effects. Some users need just 50-100mg to start to have visuals. The general consensus however is that doses of over 350mg is needed to give full visual effects with doses of 500-600mg producing full delirium. Intravenously it is around 4 times more potent.
It can also be insufflated having around double the potency of oral adminstation.
[top]Effects of Cyclizine
Strengthens 'nod' effects
Strong psychoactive effects such as visual and auditory hallucinations
Increased rush when injecting
As a deliriant
Visual and audio
hallucination indistinguishable from reality
Doing things out of character
Increased heart rate
Increased urination or sometimes difficulty urinating
Causes nausea at higher levels instead of reducing it
Random twitches and involuntary movement of limbs
Jaw tension, 'gurning'
Jumpiness, anxiety, fear
600mg oral dose:
I was talking to my girlfriend, following her round the house and even annoying her, however she wasn't there. This was by far the most realistic of these types of true hallucinations I've had. She would talk to me and I would respond, then she would looked pissed off. I didn't dare ask if she was real or not just incase she was..........
........At some point I also put some of the cushions in the bin, why I have no idea.
[top]Combinations with Cyclizine
- Increases the deliriant effects lowering the dosage required. Would be very dangerous if large amounts of alcohol were involved due to state of confusion and complete huge reduction in motor functions and reaction times.
350mg Cyclizine + 6 shots of alchohol - This experience report is relatively innaccurate due to confusion and memory loss.
SWIM does however remember the feeling that he was incredibly heavy and found it very difficult to move. Also multiple hallucinations previously stated were present. In hindsight this was dangerous and irresponsible, i remember feeling psychologically effected from this experience due to terrifying hallucinations.
Opiates - Strong potentiator favoured over most other antihistamines. Usually combined intravenously whereas other antihistamines cannot be injected. Used to be sold in conjunction with Dipipanone in a drug called Diconal but was discontinued due to high abuse potential. Is often combined with methadone
and buprenorphine to simulataneously reduce nausea and itching and increase euphoria, sedation and create a psychedelic
Possible negative drug interactions
Potassium Chloride/Citrate (solid oral formulations) - Increased risk of upper gastrointestinal injury
Propoxythene (Darvon) - Could add to the CNS and respiratory depression effects
Sodium Oxybate (GHB
) - Could add to the CNS and respiratory depression effects
Topiramate and Zonisamide (zonegram)- may potentiate the risk of oligohidrosis and hyperthermia
particularly in pediatric patients
Possible disease interactions:
Asthma - may reduce the volume and cause thickening of bronchial secretions leading to increased obstruction of respiratory tract.
Cardiovascular - it can effect heart rate
[top]Different Uses for Cyclizine
As an anti-emetic:
Orally 25-100mg up to 3 times a day
I.V. 25-50mg up to 3 times a day