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Clonidine

Clonidine is a drug that acts as an alpha-2 adrenergic agonist, the main effect being lowering blood pressure because it decreases the release of norepinephine and epinephrine (adrenalin). It is prescribed for people with high blood pressure, as well as being the main pharmacological remedy for opioid withdrawal due to its effects on the central nervous system. It helps alleviate some of the physical withdrawal symptoms such as excessive sweating and hot/cold flashes.

Contents




[top]Introduction to Clonidine



[top]Using Clonidine

Clonidine can be taken orally as prescribed for high blood pressure. Its use has also been reported in shaving soaps.

[top]Ways of Administration

[top]Taking Clonidine Orally

[top]Snorting Clonidine

[top]Injecting Clonidine

[top]Plugging Clonidine

[top]Effects of Clonidine

Clonidine lowers blood pressure and eases symptoms of opioid withdrawal such as hot/cold flashes and excessive sweating. Clonidine can make the user drowsy or sleepy, and these effects are more prominent if clonidine is injected. Clonidine can have some anxiolytic (anxiety reducing) effects as well by relaxing the body.

[top]Combinations with Clonidine

[top]Different Uses for Clonidine



[top]Pharmacology of Clonidine

Clonidine is an alpha-2 adrenergic agonist. Activation of these receptors decreases release of norepinephrine and epinephrine. Clonidine lowers blood pressure.

LD50 (mg/kg) (as the hydrochloride) [1] :
Mice : 328 orally, 18 intravenously
Rat : 270 orally, 29 intravenously


[top]Chemistry of Clonidine


Systematic (IUPAC) name:N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
Synonyms:2-(2,6-dichloroanilino)-2-imidazoline, 2,6-dichloro-N-2-imidazolidinylidenebenzenamine, 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2), 2-[(2,6-dichlorophenyl)-imino]-2-imidazoline; ST-155, Catapres, Catapressan, Clonistada, Dixarit, Duraclon, Isoglaucon, Paracefan (hydrochloride)
Molecular Formula:C9H9Cl2N3, C9H9Cl2N3.HCl
Molar mass:230.09 g/mol, 266.55 g/mol (hydrochloride)
CAS Registry Number:4205-90-7, 4205-91-8 (hydrochloride)
Melting Point:130C, 305C (hydrochloride)
Boiling Point:no data
Flash Point:no data
Solubility:Freebase freely soluble in methanol, alcohol; Hydrochloride 1 g dissolves in 6 mL water (60C), about 13 mL water (20C), about 5.8 mL methanol, about 25 mL ethanol, about 5000 mL chloroform; soluble in absolute ethanol; slightly soluble in chloroform; practically insoluble in ether
Additionnal data:none
Notes:Freebase aspect : white to almost white crystals
[1]


[top]The Dangers of Clonidine

[top]Danger 1

[top]Danger 2

[top]Danger 3

[top]Danger 4



[top]Producing Clonidine



[top]Forms of Clonidine

[top]Tabs



[top]Legal Status of Clonidine

[top]United Nations

[top]USA

[top]EU

[top]Other Countries



[top]History of Clonidine

[top]Popularity of Clonidine over time




[top]The Latest Clonidine Threads


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[top]References


[1]Merck Index, fifteenth edition (2013)


Contributors: John_bob, Alfa, Docta, NeuroChi
Created by NeuroChi , 12-04-2012 at 02:48
Last edited by John_bob, 09-05-2014 at 14:07
0 Comments, 19,246 Views

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