Acetaminophen when used in combination with alcohol
is known to cause severe liver damage.
High doses of acetaminophen are also associated with liver damage.
The maximum amount of acetaminophen to be taken in one dose should not exceed 1,000mg. The maximum amount of acetaminophen to be taken in 24 hours should not exceed 4,000mg. Recently, the FDA lowered the maximum recommended daily dose to 3,000mg in order to combat acetaminophen overdoses taken by various medications containing the ingredient. Single doses should be separated by 4-6 hours.
Single doses or daily amounts over these amounts can lead to severe liver damage or even failure. If you or someone you know has taken an overdose of acetaminophen, prompt medical attention is necessary. Treatment for such overdoses must be given early, and the apparent effects of liver damage or failure may not be present for 24-72 hours.
Liver damage/failure can be completely asymptomatic
in the early stages.