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4-AcO-DMT or O-acetylpsilocin is a synthetic tryptamine psychedelic. 4-AcO-DMT is structurally similar to psilocybin and psilocin (the psychoactive chemicals found in some mushrooms of the genus Psilocybe) and is proposed to be metabolized, at least in part, by acetylase enzymes into psilocin when consumed. Its effects are often described as very similar to those of Psilocybe mushrooms.
O-acetylpsilocin, also known as psilacetin and 4-acetoxy-N,N-dimethyltryptamine (4-AcO-DMT), is a synthetic tryptamine psychedelic. It is structurally similar to psilocybin (O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine) and psilocin (4-hydroxy-N,N-dimethyltryptamine), the major psychoactive compounds in mushrooms of the genus Psilocybe.
It is often noted that the effects of 4-AcO-DMT are markedly similar to those of consuming psilocybin containing mushrooms. This similarity is thought to be the result of both 4-AcO-DMT and psilocybin being metabolized into the same psychoactive compound, psilocin, after consumption.
The effects of 4-AcO-DMT are therefore primarily psychedelic, and similar to those of consuming psilocybin containing mushrooms.
Increased energy, stimulation
Enhanced tactile sensations
Enhanced appreciation of music
Sense of spiritual insight/fulfillment
Strong amplification of emotions (both positive and negative)
Visual and auditory hallucinations
Accelerated but unfocussed thought processes
Altered perception of space and time (especially at high doses)
Mydriasis (pupil dilation)
Emotional instability (sense of terror, paranoia, panic attacks, psychotic episodes)
Dysphoria and confusion (increased risk of inadvertent injury)
Temporary hypertension (elevated blood pressure)
Jaw clenching / gurning
Gastrointestinal discomfort (nausea, abdominal cramps, diahrrea)
Inability to concentrate
4-AcO-DMT is believed to act primarily as a prodrug to psilocin. It is believed that following consumption, endogenous acetylases remove the acetyl group from the molecule, liberating psilocin. Psilocin acts primarily via agonism of the 5-HT2A subgroup of serotonin receptors, resulting in effects typical of the 'traditional psychedelics' (psilocybin and LSD).
This is analagous to psilocybin (the major endogenous alkaloid in mushrooms of the genus Psilocybe) acting as a natural prodrug to psilocin. Support for this theory appears to have arisen at least in part from subjective reports suggesting the effects of 4-AcO-DMT to be remarkably similar to that of consuming Psilocybe mushrooms. There is however no empirical evidence to support or refute this hypothesis as yet, since few if any scientific studies on the topic of 4-AcO-DMT have ever been published.
4-AcO-DMT may also be psychoactive in its own right, much as psilocybin acts as both a prodrug to psilocin and as a direct serotonergic agonist. The extent to which the parent drug contributes to the psychoactive effects remains unclear, since the rate of deacetylation to psilocin, and the affinity of 4-AcO-DMT for serotonin receptors is unknown.
UK: Class A controlled substance under the Misuse of Drugs Act 1971.
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