Quantitative analysis of 33 benzodiazepines, metabolites and benzodiazepine-like substances in whole blood by liquid chromatography-(tandem) mass spectrometry (2004)

[Jatelka]

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J Chromatogr B Analyt Technol Biomed Life Sci 2004 Nov 5;811(1):13-20

Smink BE, Brandsma JE, Dijkhuizen A, Lusthof KJ, de Gier JJ, Egberts AC, Uges DR.

A quantitative method using high-performance liquid chromatography-mass spectrometry (LC-MS, ion trap) after matrix supported liquid-liquid extraction is described for the simultaneous determination in whole blood of 33 benzodiazepines including metabolites and benzodiazepine-like substances. The limits of detection (LOD) range from 0.0001 to 0.0126 mg/l. Linearity is satisfactory for all compounds. The extraction recoveries for the benzodiazepines in whole blood are between 60 and 91%, desmethyldiazepam, OH-bromazepam and brotizolam excepted. Selectivity, accuracy and precision are satisfactory for clinical and forensic purposes

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[DrGonzo]

Phew boy, benzos will F you over if you don't find an M.D. to write you a prescription. Many moons ago, I took Diazepam (a.k.a. Valium) for 2 weeks as a sleep aid, and it showed up months later on a drug panel. Diazepam is especially bad, since both it and its metabolite oxazepam have half-lives of *about* 1,000 years... But they're all really terrible in terms of elimination time.

If you like benzos, find a quack, it's cheaper and safer!