Combinations - Most inclusive Fantasy combos!

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This is not a thread about what you have taken, will take, or even what you can get hold of.

In pursuit of obscure, arcane and yes, even trivial knowledge of the mysterious depths of stimulants and depressants, and whatever else you wanna dream, see if you can list as many different drugs in a single category, but which are not chemically related, or just acting on about the same receptor or pathway.

Rack your brain for the most bizarre lesser known little tidbits to add to the list.

Pharms, plants and illegal drugs are all acceptable in the lists, but they must be meaningfully different, and they must work.

Here's two examples to start off.

STIMULANTS

Methamphetamine

Cocaine

Caffeine

Pemoline

Pipradrol

Phenmetrazine

Betel

Nicotine

I hesitated about including something like modafinil, because it's a long term slow build up of effects, and not exactly euphoric.

So, for that list, you could not add say, theobromine, because it's a cousin of caffeine and works on the same pathway. Ditto dexamphetamine or even ritalin is too similar to meth to be included.

Now ecstacy would be a difficult one, because it's chemically so similar to other amphetamines, but in some senses a world away when it comes to effects. Would you include it? Or would you just say, no, it's an amphetamine.

Phenmetrazine is NOT an amphetamine, neither in structure nor action, so it is included.

All the others are in a class of their own, so they get included.

Ok, next up, the ultimate downer combo:

Barbiturate
GHB
Quaalude
Diazepam
Miltown
Kava
Bromide
Chloral hydrate
Alcohol
Paraldehyde
Doxylamine

Now, that's a good list to spark debate. For instance, is paraldehyde different enough from chloral to include?

I could have put zolpidem on the list, and while it's chemically different from diazepam, they're both working on roughly similar gabby gab gaba type pathways, so should they qualify as different?

I could have put thorazine, it's certainly a downer, but is it fun enough to count [since these would be only recreational combo's, by gosd no doctor would ever sign off on such madness]

Where would propofol be left relative to such a list? it's certainly abused, which makes it harder to classify.

That leaves doxylamine and bromide hard to include too, because not many people would call them euphoric, although doxylamine is often used by junkies desperate to quell the sleep depriving cramps and sneezing fits that accompany withdrawals. Clonidine is a drug like that too, not used for kicks on the way up, but often sought for relief on the way down. Where do drugs liek that get classified?

Ramelteon helps induce sleep, but does not cause the sort of drunken intoxicated state if sleep is not achieved.

I didn't put in any opiates because to me they are in a class of their own, not classifiable as mere downers.

Also, I've tried to avoid doubling up, because then you'd get a mess like this:

diazepam-oxazepam, temazepam, benzodiazepoxide, nitrazepam, flunitrazepam all listed as separate despite being just variations on a theme

likewise barbiturates-phenobarbitone, amylobarbitone, sodium pentothal would all get [in my view tautologically] separate listings

ditto ghb, butyrolactone, butanediol, ghb salts etc.

finally triprolidine, diphenhydramine, promethazine, they're all working on the same histamine/anticholinergic axis as well.

I also would not include mugwort, valerian or hops because there is no concensus that they work, but with kava there is enough to put its efficacy beyond dispute for inclusion in such a list, and it does in fact work in a unique way that merits inclusion.

Ok, as one last thing, here are euphoric analgesics, and there are more different types than you would have expected

Peptide endogenous opioids, unique because they are made of amino acids

opiATES [strictly from papaver species and their immediate derivatives]

Piperidine and piperidone based synthetic opioids, which in some cases are structurally different from opiates [ie, although they all, including others elsewhere on the list, must have the nitrogen ring, these don't have the three part phenanthrene that is such a common backbone to natural opiates]

Mitragynine type drugs, from kratom, including all the different variations

Picralima nitida type drugs such as pseudo akuammigine or whatever it is

and finally tramadol, which, while not a narcotic analgesic in the true sense, and not even an opioid in the true sense, is nevertheless a euphoric analgesic.