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MDAI( 5,6-Methylenedioxy-2-aminoindane) has just became available on a popular RC site, and SWIM is interested. There isn't much on-line info about it besides a small Wiki article. Any swimmers had any experience with it? Is it worth SWIMS time and money? Also SWIM was thinking about mixing it with methylone...
Please post info about 5,6-Methylenedioxy-2-aminoindane (MDAI) here.
Can anyone add information about:
• names / synonyms
• side effects
• legal status
• have there been any reported incidents with this compound?
• since when has this research chemical been available?
• stability of the molecule / compound
5,6-Methylenedioxy-2-aminoindane (MDAI) was developed at Purdue University by David Nichols. It's a highly selective serotonin releasing agent. It can produce empathogenic effects but without any stimulant action.
if there is not enough dopamine, maybe mephedrone could be better to mix with than methylone? meph feels much speedier than m1 to swim. very interested in the substance as well, but a bit afraid that if it was any good, it would be already popular. well lets hope it is a forgotten gem and the price will be reasonable too
Don't take MDAI with an SSRI. This is an educated guess. I don't have any references to support this.
Correct me if I'm wrong.
what, such as 5-HTP? Ive never tried this but ive heard it increases your serotonin levels back to baseline if they have been low, but ive also heard of this SSRI, which sounds a tad scary. Swim and his mates were discussing whether combining 5-HTP with methylone would create a sort of "self-sustaining" high with the methylone using up serotonin and 5-HTP replenishing it, but if this is dangerous, swim would rather hear a few positive reports before swim tested it out. On a further note, this SSRI, is it only likely to happen if you mix the two, or also if you take them on seperate occasions, or even with one not the other?
bazbonehead added 2 Minutes and 6 Seconds later...
sorry when i refer to SSRI, i mean to say serotonin syndrome. cannabis is confusing!
Last edited by bazbonehead; 26-08-2009 at 21:05.
Reason: Automerged Doublepost
what, such as 5-HTP? Ive never tried this but ive heard it increases your serotonin levels back to baseline if they have been low, but ive also heard of this SSRI, which sounds a tad scary.
I think he's more referring to things along the lines of Prozac or Zoloft, something along those lines. SSRI's are selective serotonin reuptake inhibitors. So imagine a sink, the amount of water in the sink is your level of serotonin - the more water, the 'higher' you are. Taking MDAI would be like turning up the sink a lot. Now the water level is rising somewhat, and it meets the amount of water being drained halfway up the sink. Taking an SSRI doesn't increase serotonin, it just inhibits it from being metabolized. So this SSRI basically is like clogging up the sink a lot. Serotonin Syndrome, in this analogy, is when the sink overflows, because the drain is clogged AND a lot of water is comin out. Hope this helps somewhat.
Anyway, lots of people who do MDMA take 5HTP prior to or after their roll to feel better the next day. Swim hasn't done E before but of his friends who do this, some report it helps them somewhat, others report that it's all placebo.
So... Do any swimmers think that a starting dose of 250mg would be a bad idea?
Yes this substance is new and has had very little human testing,so start low and work your way up,you can always take more of a drug once youve established how its going to affect you,you can never untake a drug.
^yea you are right. Was kinda a stupid question for SWIM to ask. SWIM inst new to the RC game, and knows to always start small. He is just a lil antsy and looking to get the most bang out of his buck..
SWIM has taken this a few times in the past couple of months.
He started of with a low dose of 80mg and could hardly even notice any effects.
Even 150-200mg was a very mild experience. SWIM found a dose of 250-300mg to be a worthwhile experience.
Swallowed it took a long time to feel anything, 90 minutes but plugged was about 60 minutes.
i would suggest if this chem is pricy you dont wanna waste any, or any of your time doing it. If you take a low dose you may never be able to reach a desired level of effects by re-dosing if u dont feel anything. I would follow the advice above, happy swimming
Four cyclic analogues of the psychoactive phenethylamine derivative 3,4-(methylenedioxy)amphetamine were studied. These congeners, 5,6- and 4,5-(methylenedioxy)-2-aminoindan (3a and 4a, respectively), and 6,7- and 5,6-(methylenedioxy)-2-aminotetralin (3b and 4b, respectively) were tested for stimulus generalization in the two-lever drug-discrimination paradigm. Two groups of rats were trained to discriminate either LSD tartrate (0.08 mg/kg) from saline, or (+/-)-MDMA.HCl (1.75 mg/kg) from saline. In addition, a 2-aminoindan (5a) and 2-aminotetralin (5b) congener of the hallucinogenic amphetamine 1-(2,5-dimethoxy-4- methylphenyl)-2-aminopropane (DOM) were also evaluated. None of the methylenedioxy compounds substituted in LSD-trained rats, while both 3a and 3b fully substituted in MDMA-trained rats. Compounds 4a and 4b did not substitute in MDMA-trained rats. Compounds 5a and 5b did not substitute in MDMA-trained rats, although 5a substituted in LSD-trained rats, but with relatively low potency compared to its open-chain counterpart. In view of the now well-established serotonin neurotoxicity of 3,4-(methylenedioxy)amphetamine and its N-methyl homologue 1, 3a and 3b were evaluated and compared to 1 for similar toxic effects following a single acute dose of 40 mg/kg sc. Sacrifice at 1 week showed that neither 3a nor 3b depressed rat cortical or hippocampal 5-HT or 5-HIAA levels nor were the number of binding sites (Bmax) depressed for [3H]paroxetine. By contrast, and in agreement with other reports, 1 significantly depressed all three indices of neurotoxicity. These results indicate that 3a and 3b have acute behavioral pharmacology similar to 1 but that they lack similar serotonin neurotoxicity.
I think someone mentioned mixing it with methylone, which is somewhat like in mephedrone, as that might add some euphoria, but as this chemical is so new it would seem imprudent to mix it before trying it on its own.
SWIM has tried MDAI a few weeks back. Will be writing a full report on it soon, just wanted to give SWIY the nutshell verson.
254mg had SWIM feeling amazing. VERY chill, not speedy, nice and happy also. Kinda puts a dumb look on SWIMS face. lol Made SWIM and SWIMS pet very horny. They laid in bed for a while naked just rubing on each other. Kinda cloudy head space. Makes music hella nice. Mild nausa(sp) Swim did puke once but was all good after words. Would do again. SWIM redosed and added methylone later in the night will add all that in trip report.
Also the SWIMMERS took MDAI HCL now the same vendor has the MDAI Base. They say its better, any thoughts?
^Probably a little more potent due to the difference in the molecular weight, beyond that swim hasn't a clue. He hasn't tried the stuff in either form, and unless he wins the lottery (unlikely, as he doesn't buy tickets) he probably won't.