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Research Chemicals Piperazines, Phenethylamines, Tryptamines & other designer drugs.

 
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  #1  
Old 14-08-2009, 09:57
LowCrawl To Freedom LowCrawl To Freedom is offline
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MDAI (5,6-methylenedioxy-2-aminoindane) Drug Info

MDAI( 5,6-Methylenedioxy-2-aminoindane) has just became available on a popular RC site, and SWIM is interested. There isn't much on-line info about it besides a small Wiki article. Any swimmers had any experience with it? Is it worth SWIMS time and money? Also SWIM was thinking about mixing it with methylone...
  #2  
Old 15-08-2009, 01:53
thv20 thv20 is offline
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Re: Mdai

The lack of dopamine release might make this compound less interesting than it sounds. Then again, no neurotoxicity is a big plus.

Mixing with Methylone could be very sedate, lots of nice warm glow? Might also end up being a very expensive nap
  #3  
Old 15-08-2009, 05:44
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Re: Mdai

I guess there is only one way to find out....hehe :P... Also SWIM thinks mixing it with methylone would make it more stimulating.. Seeing how M1 makes SWIM feel sped up a bit.
  #4  
Old 21-08-2009, 02:34
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MDAI 5,6-Methylenedioxy-2-aminoindane

Please post info about 5,6-Methylenedioxy-2-aminoindane (MDAI) here.
Can anyone add information about:
• names / synonyms
• molecule
• dose
• duration
side effects
• legal status
• have there been any reported incidents with this compound?
• since when has this research chemical been available?
• stability of the molecule / compound

Names:
IUPAC: 6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine

Experiences with MDAI should be discussed here: MDAI Experiences page



Research Chemicals Index - Phenethylamines
Research Chemicals Index - Tryptamines
__________________________________________________ __________________________________________________ ____________

Another one from the David Nichols team at Perdue, apparently from sometime in the 90's.

Apparently derived in some sense from MDA? Reportedly non-neurotoxic, empathogenic, and is an SSRA (selective Seratonin Releasing Agent)

Last edited by Phenoxide; 30-06-2010 at 19:41. Reason: molecular structure added
  #5  
Old 21-08-2009, 04:53
runitsthepolice runitsthepolice is offline
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Re: MDAI 5,6-Methylenedioxy-2-aminoindane

5,6-Methylenedioxy-2-aminoindane (MDAI) was developed at Purdue University by David Nichols. It's a highly selective serotonin releasing agent. It can produce empathogenic effects but without any stimulant action.

Looks not that exciting.

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Good information
Agree. Important information, concisely stated.
  #6  
Old 23-08-2009, 05:09
Terrapinzflyer Terrapinzflyer is offline
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Re: MDAI 5,6-Methylenedioxy-2-aminoindane

different strokes for different folks turtle supposes.

Empathogenic, non-neurotoxic and non-stimulant sounds like a substance worth exploration to turtle...
  #7  
Old 24-08-2009, 11:24
yaniczka yaniczka is offline
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Re: Mdai

if there is not enough dopamine, maybe mephedrone could be better to mix with than methylone? meph feels much speedier than m1 to swim. very interested in the substance as well, but a bit afraid that if it was any good, it would be already popular. well lets hope it is a forgotten gem and the price will be reasonable too
  #8  
Old 25-08-2009, 19:27
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Re: Mdai

SWIM has taken this a few times in the past couple of months.
He started of with a low dose of 80mg and could hardly even notice any effects.

Even 150-200mg was a very mild experience.
SWIM found a dose of 250-300mg to be a worthwhile experience.
Swallowed it took a long time to feel anything, 90 minutes but plugged was about 60 minutes.

By far the best experience was 300mg of MDAI plugged and 250mg of Mephedrone 2 hours later.

By the way it is a tan powder.

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Nice comprehensive statements on the dosage of this relatively unknown compound. More details would be even better.
please include your weight/build when posting dosages
Thanks for the dosage and onset info.
Thanks for dosage info - if possible always add your weight also
  #9  
Old 26-08-2009, 07:08
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Re: Mdai

^Hmm i guess SWIM will start with like 250mg. He thinks that sounds reasonable Mabye throw in a 250mg bomb of M1 in there a couple hours into it.
  #10  
Old 26-08-2009, 19:04
runitsthepolice runitsthepolice is offline
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Re: Mdai

By the way, mdai (serotonin releaser)+ssri (serotonin reuptake inhibitor)=serotonin syndrome, which is bad.

Don't take MDAI with an SSRI. This is an educated guess. I don't have any references to support this.

Correct me if I'm wrong.
  #11  
Old 26-08-2009, 20:05
bazbonehead bazbonehead is offline
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Re: Mdai

Quote:
Originally Posted by runitsthepolice View Post
By the way, mdai (serotonin releaser)+ssri (serotonin reuptake inhibitor)=serotonin syndrome, which is bad.

Don't take MDAI with an SSRI. This is an educated guess. I don't have any references to support this.

Correct me if I'm wrong.
what, such as 5-HTP? Ive never tried this but ive heard it increases your serotonin levels back to baseline if they have been low, but ive also heard of this SSRI, which sounds a tad scary. Swim and his mates were discussing whether combining 5-HTP with methylone would create a sort of "self-sustaining" high with the methylone using up serotonin and 5-HTP replenishing it, but if this is dangerous, swim would rather hear a few positive reports before swim tested it out. On a further note, this SSRI, is it only likely to happen if you mix the two, or also if you take them on seperate occasions, or even with one not the other?

thanx

bazbonehead added 2 Minutes and 6 Seconds later...

sorry when i refer to SSRI, i mean to say serotonin syndrome. cannabis is confusing!

Last edited by bazbonehead; 26-08-2009 at 20:05. Reason: Automerged Doublepost
  #12  
Old 26-08-2009, 20:46
EscapeDummy EscapeDummy is offline
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Re: Mdai

Quote:
Originally Posted by bazbonehead View Post
what, such as 5-HTP? Ive never tried this but ive heard it increases your serotonin levels back to baseline if they have been low, but ive also heard of this SSRI, which sounds a tad scary.
thanx

I think he's more referring to things along the lines of Prozac or Zoloft, something along those lines. SSRI's are selective serotonin reuptake inhibitors. So imagine a sink, the amount of water in the sink is your level of serotonin - the more water, the 'higher' you are. Taking MDAI would be like turning up the sink a lot. Now the water level is rising somewhat, and it meets the amount of water being drained halfway up the sink. Taking an SSRI doesn't increase serotonin, it just inhibits it from being metabolized. So this SSRI basically is like clogging up the sink a lot. Serotonin Syndrome, in this analogy, is when the sink overflows, because the drain is clogged AND a lot of water is comin out. Hope this helps somewhat.


Anyway, lots of people who do MDMA take 5HTP prior to or after their roll to feel better the next day. Swim hasn't done E before but of his friends who do this, some report it helps them somewhat, others report that it's all placebo.

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Accurate description of serotonin syndrome
excellent analogy/explanation
wicked analogy
Phenomenal analogy
Good way to think of it.
  #13  
Old 28-08-2009, 15:50
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Re: Mdai

Has SWIY tried insufflating this substance? Is it painful?

Would it be dangerous to mix with Mephedrone (now known to be an MAOI)? If so, how long should be waited between the MDAI dosification and the Mephedrone dosification?

SWIM will be receiving 1gr of the substance in some weeks, any information you could give about the previous questions will be appreciated.



Thanks & regards.
  #14  
Old 28-08-2009, 19:02
nibble nibble is offline
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Re: Mdai

Quote:
Originally Posted by Tacitus View Post
Would it be dangerous to mix with Mephedrone (now known to be an MAOI)?
Since when has it been established that mephedrone (4-methymethcathinone) is an MAOI?
  #15  
Old 01-09-2009, 22:07
LowCrawl To Freedom LowCrawl To Freedom is offline
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Re: Mdai

So... Do any swimmers think that a starting dose of 250mg would be a bad idea?
  #16  
Old 01-09-2009, 22:24
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Re: Mdai

Quote:
Originally Posted by LowCrawl To Freedom View Post
So... Do any swimmers think that a starting dose of 250mg would be a bad idea?
Yes this substance is new and has had very little human testing,so start low and work your way up,you can always take more of a drug once youve established how its going to affect you,you can never untake a drug.

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A very acutely accurate and helpful statement, esp. that in bold, remember it people
  #17  
Old 02-09-2009, 20:55
LowCrawl To Freedom LowCrawl To Freedom is offline
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Re: Mdai

^yea you are right. Was kinda a stupid question for SWIM to ask. SWIM inst new to the RC game, and knows to always start small. He is just a lil antsy and looking to get the most bang out of his buck..
  #18  
Old 16-09-2009, 10:13
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Re: Mdai

Quote:
Originally Posted by Bluenun View Post
SWIM has taken this a few times in the past couple of months.
He started of with a low dose of 80mg and could hardly even notice any effects.

Even 150-200mg was a very mild experience.
SWIM found a dose of 250-300mg to be a worthwhile experience.
Swallowed it took a long time to feel anything, 90 minutes but plugged was about 60 minutes.
i would suggest if this chem is pricy you dont wanna waste any, or any of your time doing it. If you take a low dose you may never be able to reach a desired level of effects by re-dosing if u dont feel anything. I would follow the advice above, happy swimming
  #19  
Old 11-10-2009, 04:55
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Re: Mdai

Quote:
Four cyclic analogues of the psychoactive phenethylamine derivative 3,4-(methylenedioxy)amphetamine were studied. These congeners, 5,6- and 4,5-(methylenedioxy)-2-aminoindan (3a and 4a, respectively), and 6,7- and 5,6-(methylenedioxy)-2-aminotetralin (3b and 4b, respectively) were tested for stimulus generalization in the two-lever drug-discrimination paradigm. Two groups of rats were trained to discriminate either LSD tartrate (0.08 mg/kg) from saline, or (+/-)-MDMA.HCl (1.75 mg/kg) from saline. In addition, a 2-aminoindan (5a) and 2-aminotetralin (5b) congener of the hallucinogenic amphetamine 1-(2,5-dimethoxy-4- methylphenyl)-2-aminopropane (DOM) were also evaluated. None of the methylenedioxy compounds substituted in LSD-trained rats, while both 3a and 3b fully substituted in MDMA-trained rats. Compounds 4a and 4b did not substitute in MDMA-trained rats. Compounds 5a and 5b did not substitute in MDMA-trained rats, although 5a substituted in LSD-trained rats, but with relatively low potency compared to its open-chain counterpart. In view of the now well-established serotonin neurotoxicity of 3,4-(methylenedioxy)amphetamine and its N-methyl homologue 1, 3a and 3b were evaluated and compared to 1 for similar toxic effects following a single acute dose of 40 mg/kg sc. Sacrifice at 1 week showed that neither 3a nor 3b depressed rat cortical or hippocampal 5-HT or 5-HIAA levels nor were the number of binding sites (Bmax) depressed for [3H]paroxetine. By contrast, and in agreement with other reports, 1 significantly depressed all three indices of neurotoxicity. These results indicate that 3a and 3b have acute behavioral pharmacology similar to 1 but that they lack similar serotonin neurotoxicity.
Dr David Nichols has done work with rats on this.

http://anonym.to/?http://www.ncbi.nl...pubmed/1967651

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please check if this is in archives- if not please add or request in the medline thread

Last edited by Terrapinzflyer; 23-11-2010 at 21:28.
  #20  
Old 11-10-2009, 05:05
Terrapinzflyer Terrapinzflyer is offline
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Re: Mdai

does anyone know what the difference would be between the HCL salt and the base version of this substance?
  #21  
Old 19-10-2009, 13:49
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Re: Mdai

SWIM had a gram to play around with this stuff a while back, think it might of added euphoria mixing with other chemicals, but SWIM doesn't recall being impressed by this one.
  #22  
Old 20-10-2009, 07:17
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Re: Mdai

has anyone who isnt you combined with meph, bzp, dMAA? sounds like a good combo substance to my pet sasquatch, he would appreciate any info on this subject.
  #23  
Old 20-10-2009, 07:26
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Re: Mdai

I think someone mentioned mixing it with methylone, which is somewhat like in mephedrone, as that might add some euphoria, but as this chemical is so new it would seem imprudent to mix it before trying it on its own.

BZP is not euphoric anyway, or so people say.
  #24  
Old 21-10-2009, 23:06
LowCrawl To Freedom LowCrawl To Freedom is offline
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Re: Mdai

SWIM has tried MDAI a few weeks back. Will be writing a full report on it soon, just wanted to give SWIY the nutshell verson.

254mg had SWIM feeling amazing. VERY chill, not speedy, nice and happy also. Kinda puts a dumb look on SWIMS face. lol Made SWIM and SWIMS pet very horny. They laid in bed for a while naked just rubing on each other. Kinda cloudy head space. Makes music hella nice. Mild nausa(sp) Swim did puke once but was all good after words. Would do again. SWIM redosed and added methylone later in the night will add all that in trip report.


Also the SWIMMERS took MDAI HCL now the same vendor has the MDAI Base. They say its better, any thoughts?
  #25  
Old 21-10-2009, 23:45
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Re: Mdai

^Probably a little more potent due to the difference in the molecular weight, beyond that swim hasn't a clue. He hasn't tried the stuff in either form, and unless he wins the lottery (unlikely, as he doesn't buy tickets) he probably won't.

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