I am wondering to what extent, if any, the CB antagonist tetrahydrocannabivarin in Cannabis Sativa is implicated in the development of Cannabis tolerance? I am wondering could the CB antagonist effect of THCV reduce or slow the onset of tolerance? Particularly in light of this study it would seem plausible:
http://www.ncbi.nlm.nih.gov/pubmed/17989514
Quote:
|
Antinociception was tested in rats after an injection of either vehicle, the CB1 receptor agonist WIN 55 212-2 (WIN), an ultra-low dose of the CB1 receptor antagonist rimonabant, or a combination of WIN and the ultra-low-dose rimonabant. Ultra-low dose rimonabant extended the duration of WIN-induced antinociception. WIN produced maximal tolerance by day 7, whereas WIN+ultra-low dose rimonabant continued to produce strong antinociception, demonstrating that ultra-low dose rimonabant prevented the development of WIN-induced tolerance
|
This appears to true for the antagonist rimonabant so would the same phenomena not be observed with THCV? Anecdotally many people seem to experience relatively little tolerance from cannabis even with daily or greater use. The appearance of easily available synthetic cannabinoids in recent times has also shown that many seem to experience a more rapid onset of tolerance than with cannabis. Does anyone have any thoughts on this?
I have uploaded the full document of that study to the archive:
Cannabinoid-induced tolerance is associated with a CB1 receptor G protein coupling switch that is prevented by ultra-low dose rimonabant