An Old

[kapten]

According to Gall et al.: "simple, one-step chemical oxidation of triazolam (7) to its 4-hydroxy analogue, 7a, has been developed and applied to other triazolo- and imidazobenzodiazepines. The reaction may be used to convert diazepam to temazepam. 4-Hydroxytriazolo[4,3-a][1,4]benzodiazepines have low central nervous system sedative and anticonvulsant activity in sharp contrast to metabolites of diazepam which remain active,While 10, an alpha-hydroxy metabolite of triazolam, retains much of the activity of 7, 10a,"

To the less educated chemist, this seems tha that perhaps 7x=z(ie alprazolam) may howld promise in in boosting effects via simple oxidation.

While this is a hypothetical foray into the possibility of such easy synthesis, I have not yet had a chace to research to patents and other laborious methods.

I've anyone's looking into this, I'd be most interested in knowing.

BTW if the kapten ever did exist,hey may well have achieved in reaching his gols.