Side effects - Use of antiemetics to ease nausea caused by recreational drug use?

[honourableone]

SWIM is fed up of nausea and vomiting ruining his recreational drug use; causing drugs to be puked out before proper absorption or making what should be a great experience unpleasant. SWIM is interested in finding out whether aquiring a serious antiemetic could be a feasible solution to definitely bring an end to this problem.

SWIM wants to know how effective the better antiemetics used in medical settings are, and which ones would be most suited to easing nausea caused by recreational drugs (opioids, kratom, DXM, magic mushrooms, hawaiian baby woodrose seeds, alcohol). Are there side effects that would make use not worth it, or any combinations that may be unsafe? SWIM would appreciate any opinions and useful information here (he should be able to aquire most antiemetics), dopamine antagonists seem the most promising but SWIM will consider anything. He would prefer non-psychoactive solutions, and wants to go beyond taste masking techniques, ginger and diphenhydramine.

Thankyou

[Joe-(5-HTP)]

Swim uses Ranitidine to decrease nausea and has had no problems combining it with psychedelics however swim hasn't researched whether there are any contraindications in doing so.

[Synchronium]

I doubt any ending in *setron would be any good, as they're 5-HT3R antagonists. Great following chemotherapy (which destroys enterocromaffin cells in the gut, which contain 90% of the body's 5-HT --> loads of 5-HT makes it to the chemoreceptor trigger zone in the brainstem --> emesis), but most likely shit for anything SWIY has in mind.

That's just my own reasoning though. If anyone has any evidence to the contrary, anecodal or otherwise, please share it.

Reputation Comments on this post:

Thanks for providing some good input and information.

[Richi]

I've heard that the ingestion of cannabis produces a wonderful feeling of hunger that will help one retain an appetite and stop them from vomiting. I have also heard that it will go well with the drugs listed above.

[Guigz]

For LSD, shrooms and HBW swiy can used Trimethobenzamide, BUT ONLY FOR THIS SUBSTANCE, mixing Trimethobenzamide with alcohol, opioïde, GHB, barbiturical can be fatal!

Ranitidine can be use with some psychedelic but not amphetamine analog.
And it also potentiate methadone and buprenorphine and all the opiate in fact. With alcohol it's O.K.

Droperidol is the best antiemetic for opiates. But only in IV or IM...and not very easy to obtain...
The best antiemetic for my junkie-rat when he used opiates was THC.

Gingseng, mint, are also natural antiemetic

Reputation Comments on this post:

Thanks for giving a great range of useful information.

[honourableone]

Thanks for all the replies so far!

Originally Posted by Guigz

For LSD, shrooms and HBW swiy can used Trimethobenzamide, BUT ONLY FOR THIS SUBSTANCE, mixing Trimethobenzamide with alcohol, opioïde, GHB, barbiturical can be fatal!

Ranitidine can be use with some psychedelic but not amphetamine analog.
And it also potentiate methadone and buprenorphine and all the opiate in fact. With alcohol it's O.K.

Droperidol is the best antiemetic for opiates. But only in IV or IM...and not very easy to obtain...
The best antiemetic for my junkie-rat when he used opiates was THC.

Gingseng, mint, are also natural antiemetic

You have given SWIM some interesting lines of enquiry here, though he would rather avoid IM/IV and finding trimethobenzamide is difficult due to restrictions in the US. It is interesting that two people so far have mentioned ranitidine, because SWIM still has one 300mg tablet for when he was prescribed it for it's antihistamine properties, so he may try it out next time he has a nausea inducing drug.

Originally Posted by Jatelka

On one particularly pukey LSD trip, she also used those "motion sickness bands" to useful effect!

SWIM has never heard of these, but they seem to be a simple and easily accesible alternative to entiemetics, so SWIM will invest in some.


SWIM is still considering dopamine antagonists (in particular domperidone), so any information on this type of antiemetic would be good. They seem to be safe to combine (?), but would it reduce the efficacy of drugs that act on dopamine receptors (this question is mostly just curiosity, because SWIM it doesn't really apply to any of the drugs that SWIM listed)?

[Guigz]

Originally Posted by honourableone

SWIM is still considering dopamine antagonists (in particular domperidone), so any information on this type of antiemetic would be good. They seem to be safe to combine (?), but would it reduce the efficacy of drugs that act on dopamine receptors (this question is mostly just curiosity, because SWIM it doesn't really apply to any of the drugs that SWIM listed)?

Be carefull with the information swim give to you, because it's only valid in normal use ( without psychoactive drugs ).
Domperidone cross only weakly the hemato-encephalic barrier, unwanted effects were bound to the blocking of dopimanergic central receptor. It can be used at the same time with L-dopa to reduce the peripheral effects of this.
By analogical reasoning swim can things that dopamine receptors drug can take the place of L-dopa. No?
If somebody can confirm or contradict, it will be very usefull.

[missrogue]

The only thing SWIY really needs to consider is that antiemetics have nuerological side effects ~they work by changes in the brain that signals the body to not feel nausea or vomit These can accumulate if you take them regularly {SWIM is in treatment for cancer so uses antiemetics daily}. The side effects are tiredness or sleepiness, forgetfullness, loss of concentration and difficulty in remembering things. There are other more serious neurological effects, but SWIY would get better info on these by googling rather than from SWIM, but it is something SWIY should consider when deciding whether or not SWIY wants to use antiemetics.

Good luck whichever way SWIY choses to go



"Life is a LoveParade"

Reputation Comments on this post:

good point to take into consideration

[Jatelka]

The flamingo finds that ginger tea is effective (and tastes wonderful too!)

On one particularly pukey LSD trip, she also used those "motion sickness bands" to useful effect!

Reputation Comments on this post:

Thanks for mentioning your experience with motion sickness bands - a very simple solution that I was unaware of.

[Synchronium]

Originally Posted by Jatelka

On one particularly pukey LSD trip, she also used those "motion sickness bands" to useful effect!

Hmm, I wonder if you could extract your own scopolamine from the nightshade family of plants.


As for opiates + weed, SWIM quite often feels sick and very dizzy right after a joint during an opiate session. Perhaps that's due to a combined effect on lowering blood pressure. SWIM also tends to cough a lot more too, which doesn't help the sick feeling.

Odd, considering THC is an antiemetic and codeine (etc) are antitussive.

[Guigz]

Originally Posted by Synchronium

Hmm, I wonder if you could extract your own scopolamine from the nightshade family of plants.

Yes, but even if someboby can make the good protocol, when he have the scopolamine pur form, this person must also like playing russian roulette...transdermal patch was better than an extraction...not really easy to obtain, or with a cowl and a gun in a pharmacy

[Amnesia]

Originally Posted by Jatelka

The flamingo finds that ginger tea is effective (and tastes wonderful too!)

SWIM agrees completely with the ginger method - she says it has never failed for her. As opposed to making a tea she slowly chews on a piece of fresh, peeled ginger root, swallowing every few minutes.

Peppermint pills can be effective too but are often mixed with peanut oil so caution is advised if SWIY has nut allergies.

[slownerveaction]

I've heard of meclizine being used successfully for nausea surpression. You can buy it quite inexpensively OTC as a motion-sickness pill. Apparently one tablet (50 mg) being swallowed with a solution of the main compound of interest has the desired effect in a range of individuals.

[Politicalchalk]

Swim uses Reglan (metoclopramide) in the US. It's a great antiemetic, but might take a few tabs to work right, high difference in dosage. Also, it lowers the seizure threshold, so if you have a seizure disorder or are using drugs that lower the threshold (like say, tramadol), it can be pretty bad.

And you thought VOMITING in public was embaressing...

[RX420]

gingerale soda...

[Politicalchalk]

actually, I gotta second the ginger ale -- although here we call it "pop" noda .... soda ....

[honourableone]

SWIM has combined domperidone and ranitidine, and while the ranatidine on it's own wasn't good enough adding the domperidone makes for a good protection from nausea. SWIM takes 300mg of ranitidine and 20mg of domperidone before taking the nausea inducing drug in question. Cannabinoids do help, but it seems to SWIM that they mask most of the effects of tramadol.