5-HTP & ecstasy

[Insanoscopic]

Originally Posted by antobrun

5htp is good fro me with lsd, it help to have a nice trip, and recovery is very good

i never thought of that.. good idea

[cactus]

i find it useful to make the second day a little smoother but my girl doesnt really notice any benefits, the only thing it ever did for her was give her nightmares.


i tried pre loading twice, ithad no effect what so ever.

[zipoo]

i read somewhere that 5-htp should not be taken with vit. b6. can this be verified?

[billbryan]

Originally Posted by zipoo

i read somewhere that 5-htp should not be taken with vit. b6. can this be verified?

This is what prevents it from crossing the blood-brain barrier, the B6. As someone mentioned earlier "it doesn't cross the bb barrier" this isa false statement.It does, you have to take pure 5htp with noB vitamins which most products seem to add in their products btw, socheck the labeling before you buy.

[dolgoruki]

SWIM has only taken 5-HTP a few times, and as they were in the middle of a significant binge, SWIM can't recall any particular effects. However, according to people SWIM goes out with, 5-HTP is useful not only in cutting down the after-effects of MDMA (and related substances), but also as a build up. These people are regular consumers of ecstasy, and according to them if one takes 5-HTP regularly over the course of 5 days to 2 weeks before pill consumption one can break through the 'plateau' that generally occurs between 4 and 8 pills depending on tolerance... What SWIM means by this is 5-HTP can help one go past the point where one is basically so fucking drained anything else one consumes is keeping one going, not increasing euphoria or giving any other pleasurable effects (other than those already present). With 5-HTP, every pill one munches up to a vastly increased peak (8-12) will have seritonin for use...

God damn that was a lot of words for a pretty simple point. SWIM's gotta stop coming here while high.



Question 1 - Would regular 5-HTP use lead to a chemical dependancy, and possible inhibit the brain's normal production of seratonin, instead relying on the supplements?

Qustion 2 - Is SWIM's theory above at all scientifical plausible? It seems to be to SWIM, but then again, SWIM found this site with many questions and only a few answers.

[dolgoruki]

SWIM has seen TheTrueBlackMeat's fiending, and understands the reasons why us wee poor nooblings are not allowed the untold powers of an edit button, but SWIM is still frustrated at having to double-post...

Nevertheless, SWIM has one last question. SWIM has already found http://www.drugs-forum.com/forum/sho...-htp+synthesis which seems to ask a similar question, but the reply is inadequate for SWIM's unending, THC-induced curiosity.

5-HTP decarboxylises to seratonin, otherwise known as 5-hydroxy-tryptamine. From there, couldn't the seratonin be converted into a substance useful for clandestine chemistry? For example, could seratonin be converted to tryptamine, and from there converted to DMT? SWIM apologises for their lack of technical know-how, but believes 'on common-sense grounds' that there must be a reaction which would suffice.

[Pinkavvy]

ppure 5htp will help you fell less gloomy the day after mdma use

[snapper]

SWIM agrees. Less intense mood swings after any type of hallucinogenic. Take
right before comedown, and then the next day. SWIM used to get really
bad mood swings, especially after those long weekends. 5-htp made
most of that stess go away.
SWIM wonders where you can get 5-htp without B6 ? Is there really a
difference ?

Snapper

[oldman]

I've only bought the rite aid brand, in fact thats the only place to get it in my area. The label doesn't list any b6 or anything else for that matter. i don't know weather that means there isn't any or not. I've taken it for so long I can't really tell whether it does anything or not. I just figure it won't hurt.


If you go read that 71 page thesis "ecstacy for life" or something of that nature in Utopian Pharmacology the writer says it does help to post load, but says ther's not anything conclusive about preloading. Pre loading with phenylalanine and l-tyrosine as mentioned above apparently is of no advantage according to that report.


What I gathered from that paper was that there are at least 5 or 6 different types of seratonin that account for different feelings on e (like euphoria, enactogenic effects, energy, indirect dopamine function, loved up bliss, etc) Some types of seratoninlevels when raisedactuallyimpede the experience (ones that account for aggression, fear or even suicidal thoughts). So depending upon which specific enzymes (seratonin) are boosted by preloading with 5htp would account for some people saying it definately enhances their experience or others saying it dulled theirs, and some saying it did neither.


Conclusion -- it probably depends upon the idividuals innate or natural specific seratonin enzyme production. Some people naturallyproduce the desired types at given times.Remeber seratonin has many shapes and forms not all equal. so raising your seratonin levels pre dosing may not equate to raising the right ones. Maybe whencertain or many levels are depressed your body will replace those first. Maybe not, this part is just a hypothesis.


That paper is not an easy read but is insightful if you can pick it appart.

[Each Hit]

back in his x days, swim discovered pre- and post-loading with tyrosine and 5htp. the pre-loading never seemed to be of significant impact to the experience, but post-loading did seem to help to a small extent. swim's advice is if you can afford the supplements (which you should be able to, since you are buying drugs), then it really couldn't hurt to post-load.

[billyloner]

did a search for 5htp and couldnt find a thread


i used to pre-load with 5htp at university, used to take it for roughly a week before going out, up to the night before going out. but im sure ive read somewhere that its not a good idea to use it too close to when you go out.


wondering if anyone has any advice on using 5htp before e, such as how long to take it for and when to stop. and also any advice about afterwards (i used to just take it for a week from the night after)

[neoken]

as far as i know, you can do a preload beforehand and maybe one after
hand. just try to limit the intake to 1 to 2 pills at most. SWIM uses
them every morning before he heads into work and on some special nights
takes another one 15 minutes before he takes the happy pill and has
never had a problem with it.

[armatitumor]

I have heard that in order for it to work most effectively, 5-HTP
should be taken starting 4 or 5 days before your roll and up to the day
before. The day you're rolling, don't take any. SWIM finds post-ecstasy
5-HTP use to be quite beneficial, he takes double the recomended dose
every morning for a week starting the next morning, I'm not sure if
this is a good idea or not, and I'm not recomending it. Maybe just the
dose on the bottle will do the trick.

[Mace]

I take 100mg's daily. I've also read numerous times that it shouldnt be taken 36 hours prior to your roll, but I stop at 48 hours just to be safe. I'd also highly recommend taking Piracetam to enhance your roll. I believe it enhances it even more than 5-htp.

[Tony Blair]

I would say 5-htp is useless for preloading. For many people
(SWIM included), if 5-htp is taken up to 36 hours or closer to the
'bosh', then it severely mutes the experience.



5-htp is much much more useful for restoring your serotonin levels
afterwards. It also has antioxidant properties. Have 100 -
150mg daily for the week after 'the bosh'.



Preloading: Decent anti-oxidants in large quantities (Vitamin C, E and
Alpha-Lipoic Acid), carbfood, fruit, excercise (and piracetam is you
have any).



Postloading: See above... Substitute piracetam for 5-htp

[Mace]

Yea meglev, like I said, it shouldnt be taken 36 hours before because it can dull it. I take it as a pre-load anyway because I figure, if I do it right, it cant hurt. But like you said, it is definatly better for a postload. Piracetam is the way to go for a preload. I also take a multi-vitamin and vitamin c for my preload. Some people just take preloads to higher levels than others.

[billyloner]

thanks for the tips. ill make sure i eat plenty of fruit this week


wouldnt mind giving piracetam a go, but i wouldnt have a clue where to get it and im sure i read that shops in the uk arent really supposed to sell it either. maybe some other time when im a bit less busy... sounded really interesting though.

[dclacomb]

Piracetam is fairly common online. The price can vary drastically from site to site though.

[RealGanjaMan]

What type of stores can you find 5-HTP at?
Is it usually labeled 5-HTP or will it have a Name (For example "Mood Enhancer" or "Mood Boost")?

I looked through my local health-food store (xxxxxxxxxxxxxxxx) But all I could find were products like those mentioned above ("Mood Enhancer", "Mood Boost").

[RealGanjaMan]

And the reason this is in the ecstasy forum is because SWIM wants it for his ecstasy hangover/recovery's.

[pharmapsyche]

I've never heard of it being used for ecstacy hangover's or recovery's. But, you can find it at any xxxxxxxxxxx store. I noticed you live in the U.S. so there should defiantly be xxxxxxx store around your area.

Reputation Comments on this post:

gnc as source outside of sources forum

[radiometer]

You may have to look in a few different drugstores to find it. In some places it's available in chain stores, but not everywhere. You may have to find a "nutrition center", vitamin store, or use the internet.

5-HTP theoretically increases serotonin levels (though there is debate about how much of it crosses the BBB to contribute to higher levels in the brain), thus it is commonly used as a supplement after MDMA use to help correct any possible imbalances due to MDMA-induced serotonin release.

RGM, just don't go thinking that 5-HTP is a panacea for overusing MDMA. Serotonin levels may be one key to tolerance (and possible health issues), but the receptors themselves can also "burn out" and go through what is called down-regulation, and the only cure for this is time. The best protection from serotonin issues and tolerance that can be provided to one who chooses to use MDMA is to use it in moderation and sparingly.

As for my opinion whether 5-HTP helps in a noticable way - over many years, I've yet to tell for sure. At various times I've felt that it helped, and at others that it was worthless snake-oil. Pre- and post-loading with anti-oxidants, on the other hand, I have no doubt can provide a lot of benefit as to how one feels the day after.

[RealGanjaMan]

Ok, well I do have xxxxxxxxx around so I will go check it out. And I don't overuse MDMA and don't plan on it, I just would like to minimize the Post-roll 'depression' as much as I can.

[radiometer]

I didn't mean to imply that you did however I've seen so many threads over the years from people who take MDMA with reckless frequency, and who think that 5-HTP will solve their problems, that I feel compelled to issue some sort of disclaimer!

I think a good regimen is to take 100mg about 4-5 hours after the MDMA, 100mg again the next morning, and to take 50-100mg daily for the next few days. But I also think that taking a good anti-oxidant dose before and after the experience is even more beneficial.

SWIM takes a 300mg time-release alpha-lipoic acid tablet and one Airborne(TM) around when he comes up from the MDMA (not beforehand, as both ALA and an acidic intestinal tract are said to interfere with the potency of MDMA), and the same again plus the 5-HTP after he starts to come down in about 4 hours or so. When he forgets to take the second, later dose of this cocktail, he definitely notices the difference the next day.

[Pinkavvy]

In swim's opinion 5-htp does help alot the 2 days after ecstacy use. it can be found as 5-htp anywhere you find other nutritional suppliments. Naming stores is against the sources rule, i believe so be careful.