Drug info - Recreational potential of more unusual antihistamines?

[honourableone]

SWIM was recently prescribed clemastine, and while reading up he saw that it has anticholinergic effects and that a hallucinations are a common symptom of overdose. SWIM has minimal interest in deleriants, and has used up his prescription anyway - the point of this thread is not "The doctor gave me these pills, can I use them to get high?", but to enquire about any recreational antihistamines besides the more commonly documented ones (i.e. diphenhydramine and cyclizine) for reasons of curiosity. I am aware that many antihistamines have no recreational effects (and some consider all deleriants unsuitable for recreational use), for example you don't have to look far in this subforum to see someone explaining that cetirizine has no recreational potential because it can't cross the blood brain barrier.

I do not condone unresearched drug use, or the use of random chemicals in the hope that one will produce recreational effects (I consider the previously mentioned "Will these get me high?" style of threads are among the most worrying on D-F when they appear).

Reputation Comments on this post:

Very interesting question, should hopefully spark some good conversations.

[PandorymDMT]

Interesting question. SWIM has found that most drugs that inhibit acetylcholine (which include most anticholinegic drugs and many antihistamines), have some sort of effect on the CNS at higher end doses. After a quick search on this particular drug, SWIM has found that higher doses of this drug can lead to stimulation, euphoria, hallucinations, ataxia, incoordination, muscle twitching, athetosis, hyperthermia, cyanosis convulsions, tremors, and hyperreflexia, dry mouth, fixed dilated pupils, flushing of the face, and pyrexia, along with the usual drowsiness and possibility of coma. To SWIM this sounds very familiar to a Diphenhydramine / Cyclizine experience, but SWIM would caution SWIY against being a recreational guinea pig for unresearched and untested substances. If SWIY must try this then SWIM recommends starting with low doses and slowly working SWIY's way up with a phone handy in-case of any life-threating emergencies.