Oral use - Codeine nausea on first use

[geod]

SWIM is familiar with many substances and plants, including depressants like diazepam but has never tried any opiates, other than 20mg codeine as a cough supressant. SWIM wants to try a bigger dose of codeine and was wondering, is 100mg of codeine a big enough dose to cause nausea and positive effects to a user not familiar at all with any opiates?

The problem is that SWIM is not alone for a few weeks and a great deal of nausea/vomiting would be noticed immediately by the people living with him.
SWIM has bought an N+ pack of 12, has repeatedly ingested 1 and 1/2 pills to see if he's allergic to ibuprofen and/or codeine, and it seems he's not; he still has 9 N+ pills left. SWIM was thinking about doing a CWE, but as far as SWIM has read, ibuprofen filters harder than APAP and can be hard on the stomach, so SWIM was thinking that it may accentuate the nausea from codeine.

So, is a 90-100mg codeine dose safe enough so it won't produce any noticeable nausea?

[helikophis]

I apologise for a not very helpful answer, here it is: it might, it might not. 90-100mg is probably a reasonable starting dose. There is a chance this will cause nausea, especially in combination with ibuprofen, but it really shouldn't be anything extreme, like bad vomiting or intense pain. Watch out though, because some codeine preparations come with caffeine, and caffeine overdoses can result in severe nausea and vomiting.

Codeine alone, like many opiates does sometimes cause nausea, but really it varies from person to person, and even from use to use. Codeine itself isn't an effective narcotic - it has to be converted into morphine in the liver. Between individuals, there are significant differences in this metabolic pathway - some people convert it quite efficiently, and a small part of the population doesn't convert it at all. This will have a marked effect on the codeine experience. Short of genetic or enzyme testing, probably the only way to find out is by taking codeine.

Even in the same individual though, side effects can vary from dose to dose. Sometimes a small dose will cause nausea, other times a large dose won't. The same goes for the histamine reaction, the same dose on one occasion could produce a little bit of itching, and on another a rash, swelling, and bad itching.

100mg is not a really huge dose, but it is enough to produce significant narcotic effect in an opiate-naive good metabolizer. Some nausea might occur, but it's unlikely to be extreme. But your milage may vary - there's always a chance that a particular person on a particular day will react poorly.

Reputation Comments on this post:

Good info.

[skips]

A dose of 8 N+ on an empty stomach gives swim mild nausea, nothing too serious though and it nearly completely goes away if swim lies down.

[geod]

Thanks for the info! SWIM will try it in a few days, see how it goes and then report back here.

[anonuser30500]

To Skips - taking 8 pills of 200mg ibuprofen is a big dose - over the recommended daily usage. The brand you use has 12.8mg of codeine phosphate, so your taking just over 100mg of codeine in that dose.

To geod, I think 100mg will give all but the opiate tolerant something to think about. You would likely feel 50mg, but most here seem to edge towards the school of thought that taking 50mg, then taking the other 50mg would maybe be a let down. Each to their own I suppose, but it might be more sensible route to take.

Be careful.

Reputation Comments on this post:

Sensible advice.

[gottobekind]

Originally Posted by anonuser30500

To Skips - taking 8 pills of 200mg ibuprofen is a big dose - over the recommended daily usage. The brand you use has 12.8mg of codeine phosphate, so your taking just over 100mg of codeine in that dose.

Be careful.

Just to clarify. That's 1600mg of Ibuprofren. The recommended single dosage is 800mg. Swim has, in the past, taken far more than that. That was only after years of Ibuprofren "abuse" to combat bad bad bad teeth problems vs. a nazi doctor that wouldn't prescribe anything for the pain. However Swim digresses. The point is, from Swim's findings over the years, it's not the codeine or whatever it may be that gets you off that makes Swiy sick. It's typically the "buffer" acetominophine or ibuprofren that brings on the sickness. The only time you will suffer a sickness from codeine is in the case of what Swim calls a "partial" OD. When too much of the substance is taken in and the body sees it as a toxin and starts trying to eject it. This usually starts in the form of sweating, followed by vomiting. Swim's only word of advice is that you find a form of codeine that is low in buffer. Norco(still some buffer) or oxycodone(no buffer only wax). Swim hates to advocate the advancement of pharmaceutical abuse, but if it's making Swiy sick and Swiy wants a buzz. Then that is the only logical step. Hope Swim's rambling helps.

[skips]

Swim forgot to mention that he always performed a cwe beforehand. swim also disagrees that nausea isnt caused by codeine, any dose of 80mg+ of codeine gives swim nausea, even with cwe performed on 3 t3 pills (only 1.5g paracetemol at most and probly around 500mg after filtering). This doesnt seem to happen in most cases but it did for swim hence why he has given up even trying to get a buzz from codeine.

[miggeth]

Nausea is a common side effect, caused by a histamine reaction, it can be controlled by taking an anti-histamine allergy medication. Swim's found Loratadine works best, but once he'd been taking codeine for a while, nausea was no longer experienced.

[missparkles]

Large doses of codeine and Ibuprofen (N+) can cause nausea, promote ulcers in the stomach and could eventually cause liver damage.
Swim agrees with swi skips here...please be careful.

[officer]

SWIM gets sick sometimes on anything from 90mg
hes only ever jumped from recommended 60mg to 90mg so he has no idea about 80.
but then the next night hes fine taking 150mg+ without much sickness.
SWIM always finds 90mg to be a good hit for first dose after a while and tolerance is gone, 120 would probably be much better but because SWIM is lazy and uses 30mg cod + para tabs he cant be bothered CWE until the next night when he needs 4-5tabs.

officer added 9 Minutes and 10 Seconds later...

SWIM never does CWE on N+ its to much of a pain to work with, does SWIY have 10-12mg cod + para tabs OTC in his country? SWIM will be using OTC 10mg + para tabs soon, he cant find any 12.8's with para.
N+ is questionable if its even safe, it may have any binder in it thats binding some i to the water, the results of N+ CWE is very cloudy water and it takes ages to filter, no ones tested to see if N+ is safe? except for some people drinking solutions and saying "HEY MAN IM FINE". SWIM wouldn't do it anyway.
90mg gets SWIM off his face when he has no tolarence so its a good dose to start with, play it safe and learn your bodys reaction to it, SWIM is lucky he can get great effects on smaller doses, he thanks his liver for being able to utilize cod so well every day.

[geod]

SWIM has finally ingested the N+. He first let the 9 N+ tabs dissolve in room temperature water, then he put the water in the freezer until it was cold and filtered the solution. As SWIM didn't have any coffee filters available (they don't sell them anymore around here), he filtered it using 3 handkerchiefs. Which was not a good choice, as a lot of the water was absorbed by the hanks. The result was a white solution, but it wasn't cloudy at all, with no solids in it, just white.
Afterwards SWIM ingested the solution, but was disappointed. He thinks a lot of the codeine was lost in the CWE. He got a small buzz, a lightheadedness and a light relaxed feeling.

Next time, he will try to CWE tabs with apap. The problem is that pills that contain APAP contain caffeine here, too. And it's a pretty impressive caffeine quantity, like 20mg codeine - 43mg caffeine, 15mg codeine - 25 mg caffeine, etc.

[officer]

80-90mgs isnt enough for alot of people, some use 150+ SWIY should just keep playing with dosage until they get it right.
(eww caffeine), has SWIY tried asking for something with no caffeine they could even try going to a doc and asking for a caffeine free para tab, just get them to say N makes them very sick and they cant take caffeine? IDK its something SWIM would do lol.

[Macee]

Swim tried some codeine today and bought a generic brand of N+ (cause SWIMS sure Nurofen already has millions of dollars) and peformed a CWE on 8 pills, swim however did not have any filters so sed numerous sheets of paper towel, Swim knows that isnt a reliable way but he was just testing how a small dose of codeine could affect him.

Swim dissolved the pills in roughly 130mills of water (swim thinks he should have used more water) and then filtered it through 4 sheets of (pretty thick) paper towel, around 50mills of water came out, the rest was not coming through cause it was so thick due to the Iburofen and some was absorbed into the paper towel itself.

The water was clear, and just to test it SWIM squeezed the tiniest amount of water absorbed in the paper towel into the solution and it immediatly became cloudier. (not much so dont worry about the Iburofen) Swim drank it and it gave him a light buzz, more relaxed and just in a lighter mood.

So either SWIM is slightly sensitive to Codeine or his body metabolizes it greatly? SWIm suspects he indjested no more than 65 maybe 70 mg of codeine.

That was just to test his reaction and next time he will be trying it with the rest (around 150-200mg depending on the yeild)

[miggeth]

That sounds like a standard reaction to 70mg, swim would not go higher than 200mg next time. There is no prize for establishing swiys sensitivity quickly, and the potential penalty is death.

The most interesting time on codeine takes a while to develop anyway. Only once the body is tolerant to large doses, without being so tolerant that the effect is diminished, can swim truely appreciate the power of codeine. It cannot be sustained, but with careful planning that experience can be repeated many times within swims life.

[Macee]

Yes, next time Swim will be using the remaining 16 tablets so with a perfect extraction that would lead to 204mg of codeine, but SWIM thinks he might get 150-180mg.