Drug info - Lower Tolerance?

[Mr.Safety]

SWIM is woundering if there is any way other than time to lower tolerance? or is there any way to increase effect other than a higher dosage?

[Spucky]

There are a few way`s to do so but remember that the majority of this possibility`s
react via swiny`s Biosytem and can cause Breath-Depression, low circulation of Blood, slowed down of Metabolism, etc.!

The best Way for Opionauts are a Time off Opiates, swiny will be surprised to see
how much less he need when doing a Holiday/ Detox!

[Mr.Safety]

Originally Posted by Spucky

There are a few way`s to do so but remember that the majority of this possibility`s
react via swiny`s Biosytem and can cause Breath-Depression, low circulation of Blood, slowed down of Metabolism, etc.!

The best Way for Opionauts are a Time off Opiates, swiny will be surprised to see
how much less he need when doing a Holiday/ Detox!

If only it was as simple as that :]
Time is one thing SWIM cannot stand

[dyingtomorrow]

SWIM is not a chemist, biochemist, or anything like that, and nobody has officially said the following, but ...
it seems like NMDA Receptor Antagonists may have a side effect of lowing opiate tolerance to some degree. SWIM recalls reading a citation concerning a study (yes, yes, quite second hand) showing that Ketamine doses given to individuals who were physically tolerant to morphine lowered their tolerance and/or made it so they did not develop a tolerance from their regular morphine use. Or something like that; SWIM doesn't remember the exact specifics.

So possibly Ketamine? SWIM wishes he could get it, he would realy like to do this experiment first hand - purely for scientific purposes. Another NMDA Receptor Antagonist is DXM, so maybe it would have the same effects.

SWIM is not advising anyone else to do or try this, just posting the information he has come across and some speculation surrounding it.

Hope it helps!

[Mr.Safety]

Originally Posted by dyingtomorrow

SWIM is not a chemist, biochemist, or anything like that, and nobody has officially said the following, but ...
it seems like NMDA Receptor Antagonists may have a side effect of lowing opiate tolerance to some degree. SWIM recalls reading a citation concerning a study (yes, yes, quite second hand) showing that Ketamine doses given to individuals who were physically tolerant to morphine lowered their tolerance and/or made it so they did not develop a tolerance from their regular morphine use. Or something like that; SWIM doesn't remember the exact specifics.

So possibly Ketamine? SWIM wishes he could get it, he would realy like to do this experiment first hand - purely for scientific purposes. Another NMDA Receptor Antagonist is DXM, so maybe it would have the same effects.

SWIM is not advising anyone else to do or try this, just posting the information he has come across and some speculation surrounding it.

Hope it helps!

What a coincidence SWIM also would like to do this experiment for scientific purposes

SWIM has learned that DXM is a possibility but not to lower the tolerance, but increase the effect of H. As for Ketamine... SWIM read that it doesn't work (not proven, just other SWIY's Opinions)

SWIM just wanted to get more info from the WISE SWIY's here.

[Birkill]

K for lowering opiate tolerence????Thats a new one 2 me! Dt u not get swims pm or is one jus bein ignored, what happened 2 swidts old avaitor,swim liked it alot more!

[Hoon]

Originally Posted by dyingtomorrow

Another NMDA Receptor Antagonist is DXM, so maybe it would have the same effects.

I'll second this.

Not as a fact mind you, but I have certainly read (from a source somewhere in-between a scientific paper and the kind of discussion we're having here) that a therapeutic dose of DXM goes some way to retard tolerance build-up.

[m.swinehart81]

Getting drunk before using heroin definitely increases the effect of the heroin. Allthough Im not sure its the safest way to get more bang out of your buck... I see someone has already touched on this to a certain degree, but I will go into it a little more in detail.
Combining alcohol and heroin cause people to OD and die quite often. I cant count how many people swim has seen end up in the hospital due to this exact behavior. In the last month swim has had two friends fall out due to being drunk and then using heroin...
I really dont think alcohol is your best option for this reason. You also make stupid decisions when your drunk. I wont even go into how many options there are for stupid decisions concerning heroin that you could make because you are drunk. There are entirely way too many to even list.

[zulu1690]

swim would not recommend using alcahol to boost,swim ended up in hospital the last time swim drank a few months back.