Influence of lansoprazole treatment on diazepam plasma concentrations

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Lefebvre RA, Flouvat B, Karolac-Tamisier S, Moerman E, & Van Ganse E. (1992). Influence of lansoprazole treatment on diazepam plasma concentrations. Clinical Pharmacology and Therapeutics, 52(5):458-63.

Abstract: The possible influence of long-term treatment with lansoprazole on the single-dose pharmacokinetics of diazepam was investigated in 12 healthy male volunteers. In this double-blind randomized crossover study, 60 mg lansoprazole or placebo was administered once daily for 10 days. One hour after administration on day 7, 0.1 mg/kg diazepam was administered intravenously, and blood was collected up to 96 hours after the injection for plasma diazepam and desmethyldiazepam measurement. During the placebo session, the plasma elimination half-life, clearance, and volume of distribution of diazepam were 26.0 1.6 hours, 22.5 1.1 ml/hr/kg, and 0.82 0.04 L/kg, respectively. These parameters were not significantly different during the lansoprazole session. The mean plasma concentrations of desmethyldiazepam were similar in both sessions. These findings illustrate that long-term treatment with a therapeutic dose of lansoprazole does not interfere with the metabolism of diazepam.


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