Interethnic difference in omeprazole's inhibition of diazepam metabolism

[Bajeda]

File Archive
A new entry has been added to Pharmacology

Description:
Caraco Y, Tateishi T, & Wood AJ. (1995). Interethnic difference in omeprazole's inhibition of diazepam metabolism. Clinical Pharmacology & Therapeutics, 58(1):62-72.


Abstract:

Objectives: To compare the effect of omeprazole, a substrate and inhibitor of CYP2C19, on diazepam metabolism in white and Chinese subjects.

Subjects and Methods: The study, which took place at a clinical research center in a University Hospital, was designed as a double blind, crossover, two-stage study; each stage lasted 21 days and was separated by 4 weeks. Subjects were eight white and seven Chinese men who were extensive metabolizers of debrisoquin and mephenytoin. The subjects received, in a randomized order, omeprazole, 40 mg/day, and placebo for 21 days, followed by a 10 mg oral dose of diazepam. Diazepam and desmethyldiazepam plasma concentrations were determined by HPLC during a 26-day period after diazepam administration.


Conclusion: The extent of the inhibitory effect of omeprazole on diazepam metabolism is dependent on ethnicity. Further studies are needed to determine the mechanism responsible for this phenomenon.



To check it out, rate it or add comments, visit Interethnic difference in omeprazole's inhibition of diazepam metabolism
The comments you make there will appear in the posts below.