It is known that amphetamine
cause their stimulant effect by inducing the release of dopamine
in neuron in certain regions of the brain. 4-substituted amphetamines has been shown to possess different pharmacological properties than the unsubstituted analog. It has been shown that 4-haloamphetamines in addition to their effect on dopamine also expresses serotonin
-releasing effects, causing a long-term depletion of serotonin, indicating a neurotoxic effect, much like the one suggested to occur with MDMA
and some of its derivatives. However, among the 4-haloamphetamines, the fluoro analog seemed to be atypical in that it did not cause any long-term changes in the brain serotonin levels, even though it was also a serotonin-releasing agent like the other 4-haloamphetamines, although weaker than the other.
Tests has showed that 4-fluoroamphetamine substitutes for amphetamine in rats, but that it does not fully substitute for the serotonergic MDMA derivative MBDB
, which is the case of the other 4-haloamphetamines (which also did not substitute for amphetamine in the rats). As a conclusion, 4-fluoroamphetamine is subjectively very similar to amphetamine, but with some effect on the serotonin release, probably making the effects have a touch of MDMA-like action. Receptor interaction data suggests that racemic p-fluoroamphetamine is 2/3 as potent as d-amphetamine, probably suggesting that the racemic versions of both drugs
are almost equipotent. This seems to be an interesting analog of amphetamine for use as a stimulant, and probably the yet untested 4-fluoro-methamphetamine is too. It should be easily made by reducing the nitropropene below with Fe/HOAc to give 4-Fluoro-P2P, which can be reductively aminated with methylamine to give the target compound. Are there any pioneers out there?
Qualitative comments (Mobius):
For your information, some distant aquintance of mine tasted some p-Fluoro-Amphetamine not to long ago, motivated by a rumor that it would supposedly be much more potent than Amphetamine...
And you know what, it is slightly less potent (about 20% I would say) and is fairly different in terms of global effects... (120 mg) Slow to come on... (T + 1h) Great feeling of warmth in the face and less in the rest of the body. (T + 1.5h) Disproportionatly great feeling of euphoria
compared to the stimulation (both physical and mental) felt! Funny stuff! Doesn't compare to anything he did before and, believe me this guy has eaten a lot of exotic experimental materials and he knows what he's talking about!
NB: Above 200 mg the effect become too intense to clearly perceive the difference between this compound and regular Amphetamine.
This stuff outdid SWIM
's expectations. Very nice! 140mg material was eaten, and took about 45 minutes to onset. There's been some reports that say it is "somewhere between MDMA and meth
" which is a pretty dead-on statement. A bit of background, SWIM is a recovering meth addict and currently taking zoloft
. SWIM also "lost the magic" some time ago with MDMA, and wasn't really expecting a whole lot from the 4-fluoroamphetamine. Once it kicked in however, there was a very strong "nice-head" feeling, pretty euphoric like MDMA. Also, a distinct stimulation, though this stuff felt rather less harsh on the body than standard amphetamine sulfate. It had an excellent energetic body high similar to meth, and promoted lots of talking. The sexual drive wasn't as strong as with meth however. The nice head-high and slight lowering of inhibitions were very MDMA-like, and pretty fun. Strong worthwhile head- and body high went for a good 4-5 hours, afer which it slowly passed leaving a more or less standard amphetamine high for several more hours. After about 10 hours, some valium
was taken and sleep wasn't too hard to accomplish. Felt just tired the next day, not too braindead. The day after was IMO not as bad as that of MDMA's day after.
From a few other testings it has been determined that a boosting dose (of say 50 mg) about 2 hours into the high is alright, but trying to redose at any amount once you begin to come down just produces prolonged and less comfortable stimulation lacking the real fun of the drug
SWIM was quite pleased at the yield, considering the small volcano that happened accidentally during reduction. This synthesis is a pretty convenient one, not hard to carry out at any point.