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Old 17-06-2009, 02:42
happycamper happycamper is offline
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Clomipramine (Anafranil) and MDMA

Hey first time poster!

There have been many threads about SSRI's and MDMA use (not trying to repeat). Have seen that it can cause the MDMA to have no effect or worse that it can cause death (serotonin syndrome).
After reading all that SWIM was still asking about Clomipramine or Anafranil cause after looking at this drug directly I believe it might be different.
SWIM wants to take MDMA and is on this prescription drug because of OCD.

wiki says about clomipramine: Clomipramine is the 3-chloro derivative of imipramine. Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SSRI), as the primary active metabol seritonin ite desmethylclomipramine acts preferably as norepinephrine reuptake inhibitor. Other hydroxy-metabolites are also active. α1 receptor blockage and β receptor downregulation as well as postsynaptic antagonism on histamine H1 receptors and dopamine receptors have been noted.

This says that it is preferably a norepinephrine reuptake inhibitor and SWIM knows that MDMA mostly effects serotonin. Does this mean that Clomipramine is safer to take with MDMA than most SSRI since it is a second used drug after a major SSRI drug fails?

Thank you!
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