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Parnate (tranylcypromine) for a Methadone patient, safe?
I am really stuck in a problem right now. I have very bad depression and my physciatrist wants to start an MAOI on me(Parnate). However my MD tells me Parnate and methadone are a risky mix. I went on the an interaction site and I found
CONTRAINDICATED: The coadministration of narcotic analgesics and monoamine oxidase inhibitors (MAOIs) may rarely result in hypotension, respiratory depression, or coma. The mechanism is unknown but may be related to additive CNS and respiratory depressant effects. Rare case reports of severe hypotensive reactions have included propoxyphene (with multiple medications), morphine, and methadone, although others have reported the safe use of MAOIs with narcotic analgesics including methadone and morphine
So what should I exactly do in this type of position? I really want to try the Parnate because the SSRIs have not worked on me and I hear its super effective, but Im afraid of seratonin syndrome.
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