Drug info - SWIM thinks she screwed up her potentiation. Opinions?

[Venusia]

So SWIM did a CWE of 8 5/325 percs and put the liquid into a cup of 100% grapefruit juice.She pounded it in 5 minutes (it was SOOOO bitter, she couldn't go any faster), then she took 300 mg capsules and filled them with baking soda to make my tummy basic. 30 minutes later, SWIM took 2 percs and a 15 mg morphine IR. Then, she waited. . .

Not much happened. SWIM feels kinda gyped. Did she do it wrong? Should she have not put the CWE into the grapefruit juice? How did she screw up? SWIY tell SWIM.

[Bajeda]

Funnily enough, a discussion thread for an article pertinent to your question showed up a few lines down from this thread in New Posts just now:

Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition (2005)

Seems like consuming the grapefruit juice a half hour earlier would have been a better idea than concurrent ingestion.

[Venusia]

That is a very cool article! Thanks for pointing me in that direction. SWIM wonders if that bergamottin is also what gives grapefruit juice that bitter edge.

Back on topic, SWIM's issue wasn't so much that SWIM had taken the 40mg CWE liquid concurrently with the juice, but it's that she took some antacid- like pills (2 capsules of sodium bicarbonate, totalling 600mg) and took 2 5/325 percs and an MSIR 15mg 30 minutes after drinking the juice. Swim got nothin. Not even decent pain control for her post-surgical pain, let alone a lengthened, stronger feeling from the pills.

SWIM got more potentiation out of 3 Flexeril and 3 percs later on. (That caused SWIM to nod a bit and have auditory hallucinations...that was...um, interesting. Never had that happen, but SWIM had never taken 30mgs of Flexeril before.)