Ephedrine + combination info ?

[Akashik]

Swim just got a hold of some Ephedrine.
To be exact, 50 Ephedrine hcl 8 mg tablets.

Swim has never taken any before, but has heard about its recreational value.

Swim wants to know if any complete guides exist for this drug, as in how much to take, how, undesirable / desirable effects, interactions with other substances.... etc.

Swim has used the search engine on this site and has looked on erowid and cant find any info towards this drug and its interaction with 5-HTP.
Swim uses 5-HTP for depression... not on an occasional bases though...

What swim is trying to say is , is it dangerous to mix ephedrine with 5-htp (50 mg of 5-HTP consumed in a day during the morning to be exact ) or with the mentioned substances below? :

-Arginine AKG
-St Johns Wort
-Caffeine Anhydrous
-Vitamin B6
-Vitamin B12
-Selenium ( Chelate )
-Vitamin D3
-Folic Acid
-N Acetyl L Tyrosine

All these substances are from another product that contains them.

[helikophis]

There has been some reported danger with the combination of ephedrine and caffeine, including some deaths. As far as I can tell, the deaths aren't definitively linked to the drugs, but they are cited as contributing factors. See this article, for instance:

http://www.nutraingredients-usa.com/...e-combinations

I briefly scanned some scientific literature, it looks like most clinical research has found the combination to be safe, and effective in producing weight loss and at athletic performance enhancement. See this abstract, for instance:

http://www3.interscience.wiley.com/j...TRY=1&SRETRY=0

You might want to take a quick look yourself through the literature on it. My feeling would be that it's probably fine, as long as somebody isn't taking handfuls of the pills, or intensively working out in hot sun. Note that I am not a doctor and this is not medical advice.

The rest of the "Happy Pill" ingredients should be unproblematic, as far as I can tell; they're just standard food supplements, and St. John's Wort. Tyrosine isn't safe in combination with MAOIs, but ephedrine isn't one, so that's okay.

Hope that helps.

[Akashik]

Hey thanks for the reply, and the research you provided. amazing. Swim will read up on the articles soon.

One last question is, how long does it take for 5-HTP to leave the human system. Say around 50mg consumed in one day.

[helikophis]

Well, this abstract:

http://www.ncbi.nlm.nih.gov/pubmed/6187038

states:

The biological half-life of 5-HTP ranged from 2.2 to 7.4 hours, and the plasma clearance ranged from 0.10 to 0.23 1/kg/hour.

The study had a small sample size, but that should give you an idea at least.

[Potter]

One of the doktor's patients reported back that at small doses this combination produced a bit more euphoria and body rapture, but very quickly could get uncomfortable if more ephedrine was added.

Ephedrine really isn't harmful in low, sane, doses, the folks who die are usually taking large amounts and exercising, among other things (cocaine, steroids, dipshittery). It also can be problematic if taken daily for more then a month. These situations are easily avoided.

The doktor feels ephederine is probably one of the rougher stimulants on the body, shakiness, rapid heavy heartbeat, teeth clenching, and many of the other negative stimulant symptoms start at much lower levels compared to say caffeine or amphetamine. It's been a long time since the doktor last prescribed that stuff, but they seem to recall much more then 24mg got quickly diminishing returns.

So yeah, as long as the experiments start at low dose and the subject won't be subjected to strenuous exercise by all means go for it.

UNLESS your ticker ain't always right. Pretty much best to avoid ephedrine if you have any heart issues, while a single dose probably wouldn't do a person in, they may wish they were, this drug can greatly exacerbate heart issues (and make your asthma better)