Which is the most and least effective way of taking heroin?

[Junkhead23]

In particular pacman is talking about heroin no3 and the efficacy of snorting against smoking but would be interested to see the others too.

Any help would be appreciated

[nick23]

Most effective?Does pacman mean gives the best rush or length of effect?

Swim would suggest IV then smoking then plugging then snorting then oral.

[Junkhead23]

Pacman found this. He meant for general strength

It seems quite confusing it seems to state one thing then another

Can SWIY make heads or tail of this statement? It seems to say that smoked heroin is more efficient but the states that intranasal is 50% in another study which is right?

The 35–45% bioavailability of inhaled heroin is somewhat higher than that of another non-injecting route of heroin administration, intranasal snorting. For the intranasal route, Cone and Cone obtained recovery rates of total morphine of 27–31%, which are in the same range as those for intramuscular injection (34%). Despite its common practice in various countries, although not in the Netherlands, a review of the literature revealed no published data on the bioavailability of subcutaneously (‘skin popping’) self-administered heroin. When compared with the intramuscular route, the relative potency of intranasally administered heroin was estimated to be approximately 50% ( Cone et al., 1996). In another study, Comer et al. (1999) used a choice-paradigm and determined the relative potency of intranasal heroin to be approximately one-quarter of that of intravenously administered heroin. To date, no data are available on the relative potency of inhaled heroin.

http://www.drugs-forum.com/forum/sho...lablity&page=2

[nick23]

Yes,that's amazingly poorly written and as Pacman points out seems to contain contradictory information.

Can anyone translate this?

[nibble]

This would probably be better suited in the heroin subform of the opioid section but anyway..
The question you seem to be asking is which routes offers the best and worst bioavailability, the best would of course be IV injection as the bioavailabilty is 100%. The worst common route would probably be oral, and only morphine is actually delivered to the brain through oral ingestion too, none of the other heroin metabolites reach the brain in appreciable quantities. At a guess smoking would nearly certainly be a better route for freebase (No3) heroin, as the freebase isn't as readily absorbed through the nasal passage.

[Amazing Andy]

More important than bioavailibility to most users is the rush, and the acetyl groups of H allow it to cross quickly in mass amounts when injected. In addition, the bioavilibility is 100% so the way that gives the most bang for your buck in terms of duration is also the way that has the best rush, thus, IV is head and shoulders the best.

I personally think smoking and snorting a tremendous dissapointment and waste, of the two smoking is perhaps a little better but both pale compared to IV or even skin popping.

Eating is the least effective according to literature and personally i have never even heard of it done.

[nnizzle]

Originally Posted by Junkhead23

Pacman found this. He meant for general strength

It seems quite confusing it seems to state one thing then another

Can SWIY make heads or tail of this statement? It seems to say that smoked heroin is more efficient but the states that intranasal is 50% in another study which is right?

The 35–45% bioavailability of inhaled heroin is somewhat higher than that of another non-injecting route of heroin administration, intranasal snorting. For the intranasal route, Cone and Cone obtained recovery rates of total morphine of 27–31%, which are in the same range as those for intramuscular injection (34%). Despite its common practice in various countries, although not in the Netherlands, a review of the literature revealed no published data on the bioavailability of subcutaneously (‘skin popping’) self-administered heroin. When compared with the intramuscular route, the relative potency of intranasally administered heroin was estimated to be approximately 50% ( Cone et al., 1996). In another study, Comer et al. (1999) used a choice-paradigm and determined the relative potency of intranasal heroin to be approximately one-quarter of that of intravenously administered heroin. To date, no data are available on the relative potency of inhaled heroin.

http://www.drugs-forum.com/forum/sho...lablity&page=2

SWIM isn't sure if this is what SWIY is misunderstanding, but he believes the confusing sentence "When compared with the intramuscular route, the relative potency of intranasally administered heroin was estimated to be approximately 50%" means that intransally administered heroin is half as bioavailable as intramuscular. Alright SWIM thought he understood that but now that he typed it he is more confused. SWIY is confused that it says intramuscular and intranasal are in the "same range" of bioavailability but then it says intranasal is 50% as bioavailable? That's how SWIM reads it. So.... guess SWIM isn't really any help now. Whoops.

[g666d]

swim has just been doing a bit of reading on this... weird. Opinion seems to be chasing on foil best way after IV, but didn't read anything on rectal admission. Apparently foil more effective than similar methods, such as glass pipe, because H has tendency to combust/degrade when heated. When on foil can control temp more, and increase surface area of liquid (meaning more transfer to vapour phase, swim supposes)

5 secs to reach brain via lungs... pretty good (although this information was not specific to H, thinking about it probably doesn't apply). Couldn't find any information of saturation point of lungs ie what is max rate should smoke at.

Smoking increases risk of pulmonary disease, but this due to adulterants not H, according to what swim read (article on heroin helper site) Probably minimal, as site recommend smoking over IV, said less risk of lung disease than IV overdose

swim once tried putting some in a cigarette... complete waste.