Health - Anti-depressant question

[duncan_garry]

hello everyone,

i have recently been put on a anti-depressant (it is paxil a SSRI anti-depressant) and was wondering if it was still safe to take E, coke or speed??sorry if this a silly question

Thanks

[Incarnate]

Ecstasy and Speed mixed with an SSRI could result in serotonin syndrome which can be fatal

[OsCarwild]

Coke should not make any difference whatsoever. E, however, works off of serotonin, so and SSRI messes with it's effects badly. Usually doing E while on paxil will not cause anything more than a useless loss of money. It is not possible to truly roll while on SSRI's. It can be dangerous, but the dangerous side effects of combining the two are rare. So paxil and E together is mostly just a waste of money. Not sure about speed.... I'm sure there are plenty of other threads that address your questions. Just look around.

[Gradient]

duncan_garey,

My chimp agrees with the above statements made by both Incarnate and OsCarwild; the combination of MDMA with SSRIs is potentially quite dangerous. Here is a quote from another thread involving a similar SSRI compound:

Originally Posted by Gradient

sartre1985,

Welcome to the forums! The fact that you're well enough to communicate and actually worry about a past experience reveals that you likely had no dangerous interaction. In fact, some on this forum have suggested that the effects of MDMA might largely be reduced by SSRI activity. Here is an example thread:

http://www.drugs-forum.com/forum/showthread.php?t=81535

However, this is contradictory to most of the evidence derived from research. Attached is a study on the interaction of the two compounds - they indeed suggest that the interaction could generate serotonin toxicity, and caution against the combination. Please allow me to bring your attention to a few snippets of the article:

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"Interestingly, MDA concentrations in plasma and brain increased to levels higher than the control after 4 h. Elevated MDA levels in plasma and brain of fluoxetine pretreated rats didn't show a decline with time and plateaued as compared to control rats where they declined rapidly." (pg. 7)

"Pretreatment of rats with fluoxetine resulted in a twofold increase in the plasma and brain MDMA." (pg. 9)

"Previously, it has been shown that pretreatment of rats with fluoxetine (Prozac) administered up to 4 days prior to MDMA administration provides complete protection from MDMA induced long term neurotoxicity...However, no significant differences in the brain levels of MDMA in control and fluoxetine protreated group at this one time point was observed." (pg. 11)

"Co-administration of MDMA with fluoxetine to protect against long term neurotoxic effects may in fact decrease the elimination of MDMA and MDA and may lead to an enhanced risk of acute toxic effects. Furthermore, the significant drug-drug interaction observed in this investigation may have clinical implications associated with the recreational use of MDMA following pre-treatment with fluoxetine and the risk/benefit ratio of this practice needs to be viewed with caution." (pg. 11)

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One would do well to stay away from this combination in the future - the interaction of the compounds simply isn't understood well enough to enable safe administration. However, given the fact that the experience has already occurred, one shouldn't be overly concerned. If damage was to be done, one would be well aware of it during the experience. If one is still interested in this dynamic, serotonin syndrome is a great place to begin reading.

Here's a link to the thread: http://www.drugs-forum.com/forum/new...reply&p=585556
I'd strongly urge reading through the attached article, it directly discusses this point in detail. Basically, it would be prudent to avoid any serotonin agonists whatsoever (psychedelics included) in order to best avoid the likelihood of serotonin syndrome.

For future reference, please try using the search engine for topics like this one. Also, the 'search tags' function under the search drop-box is oftentimes even more effective than a simple search because you can see what other people called their threads, and browse the topics that all relate to the one of interest.

Hope this helps!

[duncan_garry]

ok thanks guys!