Interactions

[TRiiiP]

During the week, SWIM usually takes Vyvanse for ADHD, Hydroxycut max for weight loss, Fiber Choice with chromium, and multiple multi-vitamins and supplements (including green tea). On weekends, (when SWIM does not take vyvanse) SWIM likes to drink alcohol, roll on E, or take xanax/vicodin (though SWIM does not mix any of these).
I was wondering if any of these drugs have interactions or long-term effects. I have done my research but it is hard to discover what combining these will do.

[Gradient]

TRiiiP,

This is a pretty complex question, and it largely depends on what you consider to be 'long-term effects'. If one is worried about irreparable brain damage, the suggested compounds should be safe enough (assuming responsible administration). However, if one considers the development of tolerance/dependence on a compound, or a reduction in mental acuity to be long-term effects, then there are indeed interactions between the above mentioned compounds to be cautious of.

Specifically the routine use of Vyvanse and MDMA could potentially cause cross-receptor tolerance at the dopamine receptor, given enough time. This means that, over a prolonged period of time, since the two compounds have activity at the dopamine receptor, the brain will decrease the number of dopamine receptors it has in order to adapt to prolonged exposure. Vyvanse will also have minor activity at the NE and 5-HT receptors, which MDMA hits more significantly. Therefore, though these two compounds are distinct in their effects and receptor-affinities, one might allow ample time in between uses of MDMA in order to preserve the potency of the compound's effects.

In my humble opinion, Hydroxycut is a complete scam. All clinical trials with it have demonstrated a very low efficacy. Attached is a study that confirms that one would do better to invest their money in a stack of bricks to move around as a workout than to invest money in Hydroxycut. Apparently it's just too finicky and picky a compound to really be effective.

"In our present investigation we failed to detect a weight loss or fat-mobilizing effect of active herb." (discussion)

"In light of the many requirements for its effective use, it seems unlikely that the maximal effects of hydroxycitric acid will be realized in human weight loss studies unless treatment conditions are well defined and patient diet and medication compliance are tightly monitored."

"Our findings, obtained in a prospective, randomized, double-blind study, failed to detect either weight loss or fat-mobilizing effects of hydroxycitric acid beyond those of placebo. These observations, the first, to our knowledge, to appear in a peer-reviewed article using currently accepted experimental and statistical methods, do not support a role as currently prescribed for the widely used herb G cambogia as a facilitator of weight loss." (conclusion)

With regards to whether it has any interaction with Vyvanse or the other recreational substances described - it might, or it might not. However, it has yet to be demonstrated as effective, so given the fact that it's more likely to have some unforeseen interaction with the medication regularly ingested, my chimp would discontinue use of Hydroxycut until something conclusive came out. Just his two cents though.

[TRiiiP]

Thank you for such an educated answer. As for the Hydroxycut, I have heard that since I started using it a few days ago... not planning on buying it again but only time will tell.