Other - Bioavailability of methylphenidate when taken by different methods?

[blipblop]

Can't find a post anywhere comparing different methods of use and the bioavailability of methylphenidate.
Wikipedia has the bioavailability listed as 11-52%, I'm guessing that's for oral use?
What about insufflation?
Sublingual?
Any ideas?

[no-go]

Swim has experimented a thousand different ways to increase bioavailability and has suggestions depending the particular pill form and MFG. Of course no one here has the means to measure bioavail. prolly so bioassay is the best indication. It is not certain that Wikipedia's numbers are from pills on the market, or pure MPH, or what -- so ignore it. According to the literature Swim's familiar with, different pills are not bioequivalent and thus admit to different bioavailability, thus different plasma concentrations and plasma peaks, etc. There is no general answer, seriously.

What does swiy hope to gain by increasing bioavail. anyways? Fx. it is quite possible that MPH bioavail. is quite high, but other factors (e.g. blood sugar, caffeine, etc.) limit the preferred psychological effects, or yield unpleasant experiences, just *because* bioavail. is high. Does swiy believe bioavail. is an invariable measure of a desired psychoactive effect, or...? If nothing else give us a dose, pill form, and MFG, and what swiy hopes to gain.....

[blipblop]

Hmm, well from the information I've been looking at I've got the impression that the higher the bioavailability, the more of the chemical you're actually absorbing, so getting the most out of the number of pills available. Is that right?
So I was thinking that, theoretically if someone wanted to be getting the strongest effect from their ritalin, they'd want to find out the way to use it that got the most of the chemical absorbed into the blood.
Naturally that would be injecting, but if one didn't want to go down the IV path, would sublingual or insufflation let the body absorb the most? And would that mean the effect would be "stronger", requiring a smaller number of pills used for the same effect?
Any help appreciated, just thinking of the possibilities of what this character in my fictional book could do with her ritalin tablets. She gets 10mg tablets, not the extended release type, and can't refill her prescription for a week or so, and only has 9 tablets left.

[a4stringedwonder]

Hello, SWIM has used methylphenidate is numerous different ways trying to get the most out of it and has some suggestions. Methylphenidate has a very odd high that, for SWIM, consists of a cocaine-like feeling that lasts for maybe 30 minutes to an hour. This is immediately followed by a terrible strung out/hung over feeling that lasts the rest of the day. Not to mention an inability to sleep.

With exptended release tablets one has to use a small razor or exacto knife to shave the candy coating off of the tablet, then there is very hard plastic film covering the tablet. One has to shave that off carefull with a razor as well. The tablets have 3 different colors in them, different binders and fillers for slower or faster absobtion in the GI tract. SWIM has found that the white in the center of the tablet is the best for consumption. SWIM assumes that it is the instant release part of the tablet and usually throws away the yellow and green parts of the tablet.

SMOKING:
SWIM has tried extended release and instant release tablets. SWIM has had an embarrasing attempt at cooking the tablets with baking soda and smoking off foil. That smoking method of ingestion made for a very quick and clean high with barely any of the groggy hangover feeling that comes with the other methods of ingestion, but a nervous and jittery hangover. SWIM found SWIMself fumbling around with hot foil and feeling very embarrased about the whole ordeal. SWIM does not reccomend it.

INSUFFLATION:
SWIM believe this to be the best method of ingestion. The come up is fast and powerful even with a small ammount. Just make sure that it is the white part of the tablet if it comes from an extended release tablet. If SWIM has an instant release tablet SWIM should be able to just crush and hoot .

ORAL:
Very different high, SWIM finds it to be very unpleasant. Unless of course SWIM ingests a large ammount of methylphenidate. SWIM may be wrong but personally SWIM believes that it is potentiated by a stomach full of grapefruit juice and no food.

ANAL:
No experience in that area but SWIM assumes that it would be very intense due to the fact that Methylphenidate is absorbed well through the nose. The membranes in an ass and a nose are similar from what SWIM hears. Go for it though if SWIM wants to!!

IV:
Would most definately be the highest bioavailability out of all methods, but SWIM does not recommend it unless one has the knowledge and ability to purify the mehtylphenidate...there are many nasty fillers in the tablet that most do not want in their blood stream.

Reputation Comments on this post:

extremely detailed and helpful

[blipblop]

Thanks, really great response, a4stringedwonder. Does SWIY have any experience with sublingual use of methylphenidate?

[a4stringedwonder]

No problem Blip. SWIM is sorry but SWIM does not have any experience with sublingual methylphenidate.

But SWIM can assume that absorbtion would be effective but not quite as rapid as the insufflation method. The membranes are similar. This is based on SWIMs experience with other substances that were used sublingually...Dont take SWIMs word for it though because every substance is very different.

Cheers!

[Milk man]

Originally Posted by blipblop

Thanks, really great response, a4stringedwonder. Does SWIY have any experience with sublingual use of methylphenidate?

Sublingual is the prefered method for swim. It leaves swim with little to no comedown and he doesn't feel like shit after the high wears off.