Side effects - nausea, gettin rid of it

[nevelshaze]

todays swim had his first experiance with nausia. swim had taken percs before and only experianced very minimal nausia. but today swim had his highest codeine dosage yet. roughly 30 8/300 t1's that swim cwed. this is about 240-220 mg of codeine. swim had little food about 1.5 hours before ingesting. about 15 min after ingesting swim felt alot of anxiety. from 20-40 min after ingesting swim had quite a bit of nausia , nothin too serious but kinda was a large buzz kill. so swim was wondering is there anything swim can take or buy easily from a store that will be ok to take with codeine and help reduce his nausia? swim lives in canada.

[trannyboy]

Lay down, it should help dramatically. Almost all opiate nausea is postually induced which is just a fancy way of saying your BP is low and lying down will help. After that you can try a variety of meds or get metaclopramide or ondansetron from your doctor which should get rid of the nausea. Some here have suggested promethazine but not sure if that is available without a script. The metaclopramide and ondansetron are only available with a script but both work fairly well. The metaclopramide is much cheaper at less the 6 cents a pop then the odansetron at around 11 bucks a pop but nothing works better for SWIM then the ondansetron. They give SWIM the ondansetron at the hospital and SWIM has a vial for home use but it is so expensive that SWIM rations it out very carefully and has to be very sick to take it. Some insurance plans cover it, though mine only does if you have cancer SWIM is as sick as if they had cancer but no they say he doesn't get it. *muttering to self*In short though your best bet is just to lay down.

trannyboy

Reputation Comments on this post:

good advice in terms of antiemetics

[Synchronium]

Originally Posted by trannyboy

Lay down, it should help dramatically. Almost all opiate nausea is postually induced which is just a fancy way of saying your BP is low and lying down will help. After that you can try a variety of meds or get metaclopramide or ondansetron from your doctor which should get rid of the nausea. Some here have suggested promethazine but not sure if that is available without a script. The metaclopramide and ondansetron are only available with a script but both work fairly well. The metaclopramide is much cheaper at less the 6 cents a pop then the odansetron at around 11 bucks a pop but nothing works better for SWIM then the ondansetron. They give SWIM the ondansetron at the hospital and SWIM has a vial for home use but it is so expensive that SWIM rations it out very carefully and has to be very sick to take it. Some insurance plans cover it, though mine only does if you have cancer SWIM is as sick as if they had cancer but no they say he doesn't get it. *muttering to self*In short though your best bet is just to lay down.

trannyboy

Ondansetron is nomally only used for post-chemotherapy nausea & vomiting because the chemo destroys enterocromaffin cells in your gut. These cells store about 90% of all the serotonin (5-HT) in your body. If loads of these cells die, a fucktonne of 5-HT is released, which makes it's way to the chemoreceptor trigger zone (CTZ), responsible for initiating the vomiting reflex. 5-HT released from knackered enterocromaffin cells binding to 5-HT3 receptors here is what makes people sick following chemotherapy.

Ondansetron is a 5-HT3 receptor antagonist, which is great for stopping this type of nausea.

Opiate nausea is typically caused by opioid receptors in the CTZ, so 5-HT3 antaonists aren't as good with this type of nausea. Perhaps an opioid antagonist that does not cross the blood brain barrier would prevent the nausea (and probably the constipation) associated with opiate use.

One more thing: palonosetron is a much better 5-HT3 antagonist than ondansetron (or granisitron/dolanosetron/etc). Palonosetron's affinity for the 5-HT3 receptor is higher than the 1st gen 5-HT3 receptor antagonists, and the plasma half life is also much longer (4-10x). Also, palonosetron is believed to cause receptor internalisation, inhibiting them for much longer than a normal antagonist. See Rojas, et al. (2008) for more details.

Hope that's some food for thought.

[RoriElizabeth]

Try taking an over the counter benedryl (diphenhydramine). Just one will often take away the nausea, and not make you too drowsy. If swiy need to, taking two would be fine, but could induce more fatigue. Also, swiycould try eating some saltine/soda crackers with some sprite. It sounds simple, but it has always helped take the edge off for swim. Personally, my pet cat likes to keep an rx of phenegran (promethazine) or zofran around for times like this. They are perscription anti-nausea pills in the US, not sure if they are avaliable only by perscription in other countries. Hope that helps.

[Hover]

Originally Posted by RoriElizabeth

Personally, my pet cat likes to keep an rx of phenegran (promethazine) or zofran around for times like this. They are perscription anti-nausea pills in the US, not sure if they are avaliable only by perscription in other countries. Hope that helps.

In Canada promethazine is not Pr at the federal level but Ontario requires a script for it as it does for several other drugs that are OTC elsewhere in the country. SWIM easily obtained promethazine OTC (usually pricey Phenergan since generic is not always available, or pharmacists wanted to make more profit off OTC sales) in either pill or elixir form in BC, Quebec and New Brunswick, although in NB the pharmacist looked at SWIM funny and looked surprised to learn she could sell it OTC after looking it up on her scheduled drugs printout.

SWIY nevelshaze, SWIM is sure Phenergan (at small dose) would take care of the nausea pronto but it's one of the strongest such drugs, it's actually a phenothiazine class drug directly related to the (in)famous psychiatric tranquilizer Thorazine. It's very sedating just by itself so SWIM imagines taking it with a large dose of codeine would knock out SWIY cold thereby wasting a trip. SWIM suggests the much less aggressive dimenhydrinate (Gravol in Canada, Dramamine in the US) which has practically no side effects at therapeutic dose yet is very effective at controlling opiate induced nausea. Diphenhydramine (Benadryl, Nytol) is okay too but has slightly more side effects than Gravol.

[nevelshaze]

ty for replys , i guess ima try n get som benedryl n see how it works out. sry to hearr about your state tannnyboy

[kaczynski]

when swim used to use drugs, he found that the cliche of smoking weed to mute nausea almost always worked, unless he was extremely drunk.

[Hover]

Originally Posted by kaczynski

when swim used to use drugs, he found that the cliche of smoking weed to mute nausea almost always worked, unless he was extremely drunk.

SWIM believes it's not even a cliche anymore, but an accepted medical fact even though pharmacologists aren't sure how THC works as an anti-emetic.

SWIM doesn't use weed because it depresses him but is nonetheless impressed by its therapeutic properties.

[nevelshaze]

hey hover ty for the reply. swim used ot have motion sickness as a kid and took gravol on car rides. so thats a familier product. swim hasnt had it in a few years but thanks for the info. its very easy to obtain.

[ConcertaXL]

Phenergan is the best option if you can get it and youre not taking too much of either codeine or promethazine: you wouldnt pass out, but you would have no nausea and a leaning "purple drank" experience, but with pills!
Also domperidone may be good. It is OTC in the UK and banned totally in the US (not scheduled, FDA unapproved due to concerns over toxicity in breastfeeding) , not sure about Canada though.

[Hover]

Originally Posted by ConcertaXL

Phenergan is the best option if you can get it and youre not taking too much of either codeine or promethazine: you wouldnt pass out, but you would have no nausea and a leaning "purple drank" experience, but with pills!

Phenergan is OTC in Canada so getting it would not be a problem. Its label use for OTC sale is as sleep aid rather than anti-emetic, that's what they'll print on the bottle label. The elixir is sold as an antihistamine and is sometimes not even OTC but right on the shelves along with other common allergy medicines such as Claritin. If Swim recalls well 5ml elixir is the same dose as one white pill (25mg Phenergan, the generic same dosage pill is sometimes blue). This is the antihistamine dosage and perhaps the perfect dose to take with codeine since the red pill (50mg) is a standard hypnotic dose and might induce more sedation than needed. Phenergan suppositories are sold specifically as anti-emetic, doses are 12.5mg, 25mg and 50mg, same as pill forms.

Also domperidone may be good. It is OTC in the UK and banned totally in the US (not scheduled, FDA unapproved due to concerns over toxicity in breastfeeding) , not sure about Canada though.

Domperidone is available in Canada but Swim doesn't know if a script is required. Its label use appears to be similar to that of the more common bentylol here (nothing to do with Tylenol) which is to treat gastric disorders. Swim can see why anti-emetic properties in such a drug would be a useful bonus.

[kitch]

Swim has found that Gravol works wonders for perc related nausea. Swim takes it about 1/2 hour before percs.

[smeghead]

Domperidone is alright for nausea caused by drinking the foul shit, but SWIM found that Diphenhydramine worked better.

SWIM has just learned that another dopamine antagonist (this time that works in the CNS) is available OTC in the UK - "Prochlorperazine" (going as Buccastem M). This seems to be used for relieving migraine nausea, SWIM is wondering if it might be useful for opiate nausea. SWIM might try it once.. it's an antipsychotic at higher doses, and is no good to use for nausea for more than a few days (or so the label says)

SWIM seems to get more nausea from drinking a CWE'd mixture rather than just taking 30/500's - so his is probably more psychosomatic (he damn Hates the taste of the stuff).
Lieing down does little for SWIM unfortunately

[anonuser30500]

Swim has 30/500 prescription tablets, so if swim CWEs - the potential contaminants of paracetamol would be low (only CWE 3 tabs at most, not perfected the routine)

Be VERY careful using 30 tablets.

Swim used AFTER a meal, and the effects might actually be better, though swim uses for pain, we're talking codeine so its not an unpleasant painkiller and swim can spot the high.

Swims CWE on empty stomach did hit faster, but swim felt more nauseous because Swim was hungry. Not used any big dose as of yet, but NO WAY would Swim feel good slipping down the codeine brew into an empty stomach. Other swiy might just be that way. Swiy might not like getting high starving although maybe 240mg of codeine might stop hunger. Trouble is, that leaves your stomach eating itself with its own acid.

Any other Swiy find that they prefer to drink the drink of CWE after eating?

Swim sees maybe a 'time release' effect doing it this way, which means waves of nausea are coped with better swimthinks. For pain releif, it is better to space out the effects over a few hours, not just one blaze of glory! Consumers choice entirely.

Also, not eating is the start of a downfall for many.

As for the nausea, try a couple of biscuits and a nice cup of tea. Open up the window, curtains! get a breath of fresh air.

Last resort is a lie down - rebalance the ballasts, stop listing and steady as you blow!

Good luck out there.

[pinksox]

SWIM going to concur with the Phenergan if SWIY wants to reduce nausea and potentiate effects or Tigan if they merely want to reduce nausea. Pherngan works well, but it has a higher incidence of adverse effects...like Tardive Dyskinesia...the remedy for such, of course, is Benedryl(but its not always 100% reversible). SWIM doesn't want to walk around looking like an idiot for the rest of her life, nor does she have a need to potentiate effects, so she sticks with the safer option of Tigan.

SwiTB is also correct in that large doses of opiates can bottom out blood pressure. Lying down will help because the heart doesn't have to work so hard to supply blood to the brain.

Puking can be the body's way of trying to raise it's blood pressure through Vagus nerve stimulation or it can be because of the slowing down of the digestive system--the gut has a large amount of opioid receptors. If one is feeling light-heading with a fast heart rate, its probably the former than the latter.