Pharmacology - Vyvanse - (lisdexafetamine)

[eche05]

This is basically an extended release form of adderall (d,l-amphetamine), although this is NOT racemic. This is purely d-amphetamine (dextro, the right handed optical isomer).

This is basically amphetamine attached to a lysine (amino acid) molecuel. Your prody naturally produces a chemical called 'trypsin' in your stomach to cleave off that nasty lysine, giving you the pure euphoria associated with d-amph.

I've recently discovered a way to turn your 70mg of vyvanse into instant-release dextroamphetamine.

• Dissolve in a desired ammount of water at about 98 degress F (i'd say anything above 1 cup)
• Add trypsin, you can probably get it in some enzyme pill at a GNC, excess is not a problem
• You now have pure d-amphetamine with some possible other [healthy] enzymes which do not pose a health threat.

Aside from conversion, what are your SWIMers personal experience with vyvanse? Good, bad, everything inbetween.

[Gradient]

eche05,

I've had no personal experience with the substance, but from what I've hard, it's absolutely an interesting pharm. Two close friends, long-time methylphenidate/adderall-treated for ADD/ADHD, have reported significantly more functional effects from vyvanse. Specifically, they suggest that both the onset and comedown are far less distinct in their manifestation; they feel strongly that this particular preparation of amphetamines produces a smoother transition between behavioral states. Here's a quick run-through of what they've told me:

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One friend, a one-time avid recreational user of his medications, has terminated his recreational relationship with his medication (adderall in his case). He suggests that, due to such smoother behavioral (and therefore, emotional) transitions, urges to take higher and higher doses are alleviated. In other words, he feels that the preparation in vyvanse has proven to be a particularly stable alternative to either adderall or ritalin.

The other friend does not value vyvanse to the same degree, however, his reasons are quite similar. He does not value the loss of recreational value of the amphetamines; he considers this to be a highly serendipitous effect of the stimulant, and appreciates the fact that he can utilize a substance for both recreation and productivity. He primarily values the drug's effects during the week, utilizing it for smooth emotional transitions throughout the day that are unnoticeable to others. The fact that he doesn't appear quite as jittery and stimulated, and then suddenly behaviorally depressed and uncommunicative is a relief to him in a few ways. He now supplements his vyvanse dosing with small (10 mg and below) doses of amphetamines when he feels particularly strained for productivity.

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Sorry I couldn't produce any journal-derived information, but I suppose it's a bit early for this compound. I'm excited to hear more opinions of the drug - seems like a reasonable alteration to render the compound slightly more functionally practical. SWIM could never tolerate the comedowns associated with amphetamines, but greatly appreciated the cognitive enhancements they conferred. Perhaps this is a reasonable alternative?

-G

[eche05]

I'm excited as well, thanks for replying by the way.

Looking forward to more resposnes!