Ibogaine affects brain energy metabolism

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Description:
Ibogaine is an indole alkaloid present in the root of the plant Tabernanthe iboga. It is known to attenuate abstinence syndrome in animal models of drug addiction. Since the anti-addiction effect lasts longer than the presence of ibogaine in the body, some profound metabolic changes are expected. The aim of this study was to investigate the effect of ibogaine on protein expression in rat brains. Rats were treated with ibogaine at 20 mg/kg body weight i.p. and subsequently examined at 24 and 72 h. Proteins were extracted from whole brain and separated by two-dimensional (2-D) electrophoresis. Individual proteins were identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). Enzymes of glycolysis and tricarboxylic acid (TCA) cycle namely glyceraldehyde-3-phosphate dehydrogenase, aldolase A, pyruvate kinase and malate dehydrogenase were induced. The results suggest that the remedial effect of ibogaine could be mediated by the change in energy availability. Since energy dissipating detoxification and reversion of tolerance to different drugs of abuse requires underlying functional and structural changes in the cell, higher metabolic turnover would be favourable. Understanding the pharmacodynamics of anti-addiction drugs highlights the subcellular aspects of addiction diseases, in addition to neurological and psychological perspectives.

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Reputation Comments on this post:

always love more info about iboga, such a wonderful tool/spirit

[maninaboat]

So iboga basicaly remodels the brain in some way? Does it only apply to drug adictions or is it possible that it can change habits, like biting your nails (Bad example I know).
I Dont know that much about Iboga and I have never had the pleasure of using it, I first found out about it on a Bruce Perry documentary, where he visits a tribe and in order to be initiated into the tribe he has to trip. Perry claims to have OBE's, powerfull visions of his childhood of passed mesdermeners. ocupying the consiousness of others feeling the pain he caused them. "I understand that every action has an effect everything we do has its consequences. I see the earth as a vast living consiousness of which i am only a tiny part"


Obviously this is not a not a substance that is to be taken lightly, but what do you think the possible negative effects are? Do you think if you ended up spiraling, you could end up reprograming your brain is some wierd way?


you can find a clip of his experience here
youtube.co m/watch?v=_gFB4wVPpAU

Reputation Comments on this post:

posting videos in the forum instead of the video archive