Ampakine?

[Peyote]

Has anyone ever heard of this stuff? Its pretty new and lots of
research has been done on this drug! It improves your memory and its a
stimulant.

AMPAKINE® Technology


The
mysteries of the brain have long been an important component in the
treatment of many disorders. In understanding how AMPAKINE compounds
work, we must first understand the workings of the mind. Specifically,
how the brain communicates.

Nerve cells (neurons) in the brain
communicate with each other by releasing small molecules known as
neurotransmitters. These neurotransmitters bind to proteins, called
receptors, located on the surface of the receiving neurons. This
binding then triggers subsequent cellular events in the receiving
neurons.

The brain uses many different neurotransmitters for
communication. Each acts on a different highly specific subset of
receptors, much like a key only works in certain locks.

Many
important drugs — such as Valium®, Prozac®, Levodopa® for Parkinson’s
disease, and Haldol® for the treatment of schizophrenia — have been
developed around the various neurotransmitter families. Glutamate is
the predominant neurotransmitter in the mammalian brain, accounting for
as much as over 75% of all brain communications. Several different
subtypes of receptors recognize glutamate, and each plays a different
role in the normal functioning of the brain.

One of these
subtypes of receptors is the AMPA receptor, the primary pharmacological
target being addressed by Cortex. The AMPA receptor is involved in a
process known as long-term potentiation, or LTP – believed to underlie
the encoding of many types of memory. In addition to its importance to
memory formation, the AMPA receptor plays a central role in “excitatory
communication” in the brain. Neurons have two basic types of inputs —
excitatory and inhibitory. The relative balance between the two types
of inputs determines the activity of each neuron in the brain at any
given point in time. A reduced level of glutamate-mediated excitatory
stimulation has been implicated in Alzheimer’s disease, schizophrenia,
and a number of other diseases and disorders. Cortex’s Ampakine drugs
enhance excitatory communication, thereby partially or completely
restoring the reduced levels of glutamate-mediated communication in
these diseases.

Cortex believes that increasing AMPA receptor
activity with AMPAKINE drugs may provide a new and highly affective
approach to treating a number of central nervous system disorders.

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