Oral use - Dose quarters over time

[FrogEye]

Hi all, i know to some this may seem like a waste of acid, but SWIM wanted to experiment with this... What SWIM has done is cut a single blotter (which swim knows to be fairly good acid) into quarters and then dose each quarter over 3/4 of an hour at a time. SWIM is up to taking the third quarter now and is getting faint visuals and a body high, but not as strong as a whole dose which is to whats be expected. Its pretty fun so far just having a mild tinge to everything without being completely confused if you know what i mean. Anyway what do you guys think to this method?

[Third/Eye]

SWIM wouldn't say it's a waste of acid. It would really depend on if SWIY enjoys it or not.

How was the experiment?

[yaba]

Have to say with the acid now... Swim when he takes it (not often) he likes to take high amounts to, make it something specially.....

Won't say how much (irresponsible behavior) but its a lot.....

[Desertfox]

Tolerance occurs after the first dose passes the blood-brain barrier, hence re-dosing or taking a booster has little to no effect and is degrading the strength of your Lucy taken thereafter by about half of what it should be.
Take what your gonna take all at once, or not at all.

Reputation Comments on this post:

best advice so far, listen to this person

[Shampoo]

Originally Posted by Desertfox

Tolerance occurs after the first dose passes the blood-brain barrier, hence re-dosing or taking a booster has little to no effect and is degrading the strength of your Lucy taken thereafter by about half of what it should be.
Take what your gonna take all at once, or not at all.

Actually, tolerance occurs once a series of intracellular signals causes transmembrane proteins known as receptors to recede into the membrane or otherwise desensitize, a process known as downregulation. This process does not occur immediately following BBB-crossing, but rather takes some time to develop.

Many users have reported success with redosing psychedelics including LSD, up to several hours after ingestion of the primary dose. Additionally, gradual dosing as opposed to a single administration is a viable option with most psychedelics, and will not be interfered with by the process of downregulation.

For users who experience adverse side effects during the onset of activity, such as nausea, anxiety, muscular tension...etc. may benifit from gradual dosing. Though it is unlikely to reduce overall side-effects, those experienced during the onset may certainly be amerliorated.

Reputation Comments on this post:

	valid point, well-said
	thanks for the science, as usual

[Desertfox]

Originally Posted by Shampoo

Actually, tolerance occurs once a series of intracellular signals causes transmembrane proteins known as receptors to recede into the membrane or otherwise desensitize, a process known as downregulation. This process does not occur immediately following BBB-crossing, but rather takes some time to develop.

Many users have reported success with redosing psychedelics including LSD, up to several hours after ingestion of the primary dose. Additionally, gradual dosing as opposed to a single administration is a viable option with most psychedelics, and will not be interfered with by the process of downregulation.

For users who experience adverse side effects during the onset of activity, such as nausea, anxiety, muscular tension...etc. may benifit from gradual dosing. Though it is unlikely to reduce overall side-effects, those experienced during the onset may certainly be amerliorated.

Yes, but would you agree that the subsequent dosages would be less potent than if taken with the first dose?

[Shampoo]

Originally Posted by Desertfox

Yes, but would you agree that the subsequent dosages would be less potent than if taken with the first dose?

Perhaps, by some minute fraction subsequent doses may be less potent than the first dose, though this is probably a matter of time, potency of first dose, and a number of other factors including enzyme availability and peripheral binding. Most likely however, doses taken within one hour of the original dose would be decreased in potency by such a minimal fraction that the difference would be considered negligible.

Taking an entire dose at once will likely result in a more significant or potent onset of effects and perhaps a more "intense" peak, as the entirety of the compound is active simultaneously. Progressive dosing however results in a more drawn-out onset and peak, which may be perceived as less active by some users. This is not an indication of the potency of the compound or any downregulation, however.

Reputation Comments on this post:

Great, cl,ear, thorough explanation.

[FrogEye]

Sorry for taking time to reply SWIM has been busy. But as for this experience, it was fairly visual and there seemed to be more headspace during this experience. However, some good insights were still reached and over all it was quite an enjoyable, yet less strong trip. Swim would recommend this to new users. SWIM also argues against the fact that re dosing does not do anything, SWIM did not experience any tolerance degredation. It seemed like the trip lasted for a few hours longer than what SWIM is used to, as if the curve of intensity was stretched sideways and peaked at a lower level. Would be a fun experience if SWIM is wanting to try acid out when he goes clubbing or something similar, which is what this SWIM was trying to find out really.

Reputation Comments on this post:

Thanks for reporting back. That "curve of intensity being stretched" explains your point quite clearly your po...

[podge]

Dropping in quarters is a perfectly valid way of taking LSD blotter, it will obviously be less intense than taking the full dose at once so its more geared towards a social experience as opposed to an introspective experience. Dropping in small amounts is also good when dealing with very powerful blotters or a blotter of unknwn potency so a swimmer can get an idea of how strong they are - it can be unnerving to say the least when a swimmer realises they have dropped what turns out to be an unmanagable dose. Better too little rather than too much especially for less experienced users.

Swim does not agree with "All at once or not at all" , when a swimmer has enough experience they are better able to guage where their comfort zone is and whether they want to venture out of their comfort zone.

Reputation Comments on this post:

Good set of applications of gradual dosing.