Comparing MDMA activity with BDB, MBDB, HMA, DMMA, and other derivatives, and 2-CB

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Article published 2007. Some interesting comparisons are demonstrated. Interestingly, they suggest that 2-CB likely binds to a site that is allosteric (distinct) from the substrate binding site of the SERT- they found that the compound binds to a different site that MDMA and its derivatives bind to.

They also suggest that the alternative positions of the methylenedioxy group doesn't really affect the compounds potency at the norepinephrine transporter, but does reduce its potency at SERT. They provide the example that MDMA is twice as potent as 2,3-MDMA at SERT, while equipotent at the norepinephrine transporter.
Also, the 3,4-methylenedioxy substitutes found in HMMA, HMA, and DMMA only serve to reduce the compound's potency at both norepinephrine and serotonin transporters. Pretty cool study.