Combinations - Adderall and Tramadol ??

[Dreamland]

Alotta times what SWIM will do, is take adderall pills, and enjoy the come up and good feeling, but once they blunt out a few hours later to the 'nervous' effect, SWIM will take tramadol to mellow out the edginess...

SWIM HAS to do an opoid-based product when using stims for a smooth experience.That's SWIM fav mix just as long as the opiates aren't powerful like OC or fentanyl. but tramadol and at times hydro to go to sleep works well to balance out the effects of stims..

SWIM doesn't know if it's an o.k. interaction.. altho SWIM has been doing it for awhile without any problems, and both go hand in hand...

SWIM doesn't go overboard either with each, and knows the limits of what SWIM's body is telling SWIM if 'that's enuff'....

[psyche]

Well the thing to watch would be the stimulatng properties of tramadol. It has been known to cause twicthing and seizures in overdoses, so one needs to be careful when combining with stimulants. Mind the doses and it should be relatively safe.

[Dreamland]

Originally Posted by psyche

Well the thing to watch would be the stimulatng properties of tramadol. It has been known to cause twicthing and seizures in overdoses, so one needs to be careful when combining with stimulants. Mind the doses and it should be relatively safe.

SWIM agress cuz SWIM forgot to mention that SWIM also takes 300mg of
wellbutrin(bupropion) for depression. wellbutrin can cause sezuires but only in doses exceeded the prescribed amount. altho SWIM hasn't had any prblems with interacting amphetamines/opoids/AD's.. Even tho it's got sWIM cautious, no negative interactions.. In fact, SWIM finds that the wellbutrin would probably enhanced the dopamine increasing effects of amphetamine... SWIM's done this several times, no problem.

[Gradient]

Dreamland,

This is an unfortunately un-safe combination. Tramadol is a completely synthetic opiate: it is not only a mu-opoid agonist - and therefore an opiate - but also an SSNRI, which increases the amount of both norepinephrine and serotonin available in synapses.

Amphetamines, which are what Adderall is composed of, are dopamine agonists as well as norepinephrine, and to a lesser extent, serotonin. The combination could theoretically cross-potentiate at the norepinephrine receptor and produce a state of seizure-susceptibility.

I would think that this state of seizure-susceptibility would only be a danger when the compounds are taken concurrently. However, I'm not familiar enough with the details of transporter-binding for Tramadol or amphetamine- specifically, how long the compound stays bound to the protein - to make a definitive judgement. There is a high likelihood that, despite termination of amphetamine's behavioral effects, one remains susceptible to dangerous interaction of other compounds (like MAOIs) with amphetamines for a prolonged duration.

Sorry for the clunky post, but in sum - based on receptor-interaction, it is not a safe combination. However, it may not be something to worry about so long as you pay very very thoughtful attention to staying at somewhere around threshold doses for both - and of course, individual tolerance will always affect where these doses will be compared to other people.

Reputation Comments on this post:

	good answer
	A good answer that said all it needed to and gave plenty of information.

[psyche]

^ On a second thought, I have to agree with this. Most likely you won't have any problems combining it, but there are some cross-action that makes it questionable combination. There is a difference between book-knowledge safe and experimentally safe: not many combinations produce ALWAYS negative response. There are safer combinations out there, so it's better to be cautious and note that there are risks.

[Dreamland]

So, here's my big question- would SWIY feel i'd be safer is SWIM to just take hydro with adderall instead of tramadol, for the sake of lowering the sezuire threshold?? thing is SWIM likes hydro, and it does calm the edge off Adderall as well, but sometimes at higher amounts the hydro can make SWIM too tired and somewhat dull the effect of adderall..

SWIM was thinking no more then 10-15mg of hydro (Norco), with SWIM's usuall 30-45mg of adderall? better alternative then tramadol?

SWIM knows that it's too much on the body and rough if strong opiates such as oxy's or morphine were to be taking with amphetamines, as it was just be pointless cuz stronger opiates would knock SWIM out, but at the same time the amphetamine would be fightening to wake SWIM up.,,

which is the reason SWIM though of as it's more stimulating, and hydro to SWIM tends to be stimualting/relaxing at low doses, but higher doses would knock him out...

[Gradient]

Dreamland,

So long as one remained below the maximum daily recommended values for amphetamines, the combination of Adderall and hydrocodone (at the discused doses) should produce no dangerous receptor-interaction. From what I've been exposed to, there should be no theoretically dangerous combinations based on what the two compounds do in the brain.