Drug info - Adding aspirin to poppy tea

[G_nome]

Theoretically, what would happen, if anything?

My monkey's just been reading bits here and there and apparently adding some aspirin (not sure of specific amounts) to poppy tea and letting it react whilst heating would bring about some acetylation, thus creating 6-mam.

Any truth in this? Or is my monkey just a silly monkey?


This is, of course, all hypothetical and i wouldn't dare let my monkey try it.

[NeoGeo64]

I don't see how it would hurt the mixture as lots of opioid preparations contain APAP or aspirin (tylox, perodan). I don't know if it would change the chemical structure of the alkaloids. I'm still learning, too, though...

[samuraigecko]

acetylation of position 6 is only possible through 2 means that SWIM knows of.

1] Acetic Andrahyde and heat as the catalyst.

2] Acetic Acid and something else (not mentioned) as the catalyst.

One seriously doubts that asprin would or could bring about any acetylation.

Peace ?

[davestate]

Originally Posted by G_nome

Theoretically, what would happen, if anything?

My monkey's just been reading bits here and there and apparently adding some aspirin (not sure of specific amounts) to poppy tea and letting it react whilst heating would bring about some acetylation, thus creating 6-mam.

Any truth in this? Or is my monkey just a silly monkey?


This is, of course, all hypothetical and i wouldn't dare let my monkey try it.

For the tiny amount of Ac2O that might, very unlikely, be produced, the 3-position is acetylated first.

Just because the molecule has been made with Ac2O, doesn't mean it can acetyate.

[Routemaster Flash]

SWIM's no expert on opiate chemistry, but his instinct is that the main effect of this would be to make one's poppy tea taste even worse than usual.

[EyesOfTheWorld]

SWIM is no chemistry expert but from his limited knowledge he does doubt that any acetylation would take place here. However, if for some reason it did, your monkey would not only have 6-MAM on his hands, but also the highly toxic 6-MAC.
This experiment is best avoided as most likely it is a waste of time, but if it did work, it might kill the monkey.

[NeoGeo64]

SWIM concurs with the above poster that it will probably just make the tea taste even worse. One time SWIM used too much lemon juice and it tastes so sour and disgusting that he spit it out and poured the 3-pod tea down the drain.

SWIM doesn't use flavorings anymore and just lets it chill down for a while before drinking it... when it's cold SWIY won't taste it as much.

[samuraigecko]

SWIM produces CFO then makes any tea / laudanum / etc from that so therefor taste is not an issue ever.

Acetylation will not occur using Asprin.

Position 3 is harder to acetylate than position 6 so it probably wont even be touched.

If by some miracle position 6 DID get acetylated, then position 6 of the Codeine molecule will also get acetylated producing 6MAC. Position 6 of the Codeine molecule is even easier to acetylate than the same position in the Morphine molecule.

As everySWIone should already know 6MAC is Extremely toxic to humans. Even an antihistamine will probably be no savior. 6MAC poisoning = serious trip to the hospital AND THATS THE BEST CASE SCENARIO.

Position 6 of the Morphine molecule needs a catalyst to be acetylated and even if asprin COULD acetylate it, the catalyst is not present.

Acetic Andrahyde does not need the same catalyst to acetylate position 6 because of its unique structure. It is strong enough to acetylate both positions 6 and 3 with only the use of heat as the catalyst producing 3,6DAM, and also 3,6DAC if it is not cleaned of Codeine. 3,6DAC is also toxic as its main metabolite is 6MAC.

Peace