Effects - Oxycodone vs. Morphine

[thisguy9000]

Hello All,

New to the forum but have been lurking for a while, a lot of great information here. SWIM has done quite a bit of searching but hasn't been able to find the answer to a specific questions.

SWIM uses various opiates fairly regularly. SWIM knows that insufflating roughly 10-20mg of Oxycodone makes him feel great and is generally the does he takes when he wants to get high.

SWIM currently has the option of acquiring 80mg Oxycontin pills and/or 80mg morphone pills. While SWIM is very faimiliar with taking Oxycodone either orally or insufflated, SWIM has never taken morphine in any form. After reading about morphine, it appears to be clear that the more effective method of use would be insufflation. SWIM would like to try the morphine, wants to do it safely/effectively, but still would like to try and get the same feeling as the 10-20mg of insufflated Oxycodone. The questions SWIM has are the following:

1. Can anyone recommend (roughly) how much Morphine should be insufflated to get the same euphoria/high of the 10-20mg of Oxycodone? Would it be roughly the same? More/less? etc...

2. Is it true that morphine does not (generally) give the same euphoric/rush type high as Oxycodone does?

3. Would most members of this forum prefer 80mg Oxycontin pills over 80mg morphine pills, given the oppurtunity to acquire either/or?

Thanks for your time, I know SWIM appreciates it.

[Naked Lunch]

Do you mean Hydromorphone or Morphine? There's a difference see.
Swim would take oxy over morphine but would take Hydromorphone over oxy.

Reputation Comments on this post:

Directly answered one of my questions

[thisguy9000]

SWIM must admit that he isn't 100% sure as he isn't familar with morphone/Hydromorphone. However, after some googleing, SIWN thinks it appears that Hydromorphone doesn't come in 80mg pills, is that correct? SWIM is absolutely sure that the these pills are 80mg, but must admit he isnt sure (based on Naked Lunch's post) whether these are morphine or Hydromorphone pills. Can you elaborate on the difference?

[Naked Lunch]

I don't know much about American pills and there specifics cause I'm an Australian so you may have to wait for an American to answer your question.

[LinusMundane]

In this SWIMMERS opinion he would go with the oxy, oxy is like that friend that comforts you when you need him to most, why switch it up when it works for SWIY.

[BuffaloBoobs]

Swim only knows of 4 and 8mg hydromorphone. 80mg ... no way.
swim can't help swiy pick between oxy and morphine though.

[Herbal Healer 019]

The original poster was refering to Morphine as posted in the title & several times in the original post (did say morphone @ 1 point..spelling error).

Morphine is only ~25% orally & I think around 40% intranasally, so obviously the oxycodone (oral bioavailability ~100%) takes the cake in terms of most doses per pill.

Oxycodone is also, in Some1 Who Aint Me 's opinion, the better opiate/opioid of the 2...

[Picass035]

1. Can anyone recommend (roughly) how much Morphine should be insufflated to get the same euphoria/high of the 10-20mg of Oxycodone? Would it be roughly the same? More/less? etc...

>>>Going the insufflation route, one would need approximately 3 times the amount of morphine to match oxycodone's euphoria/analgesic effect.

2. Is it true that morphine does not (generally) give the same euphoric/rush type high as Oxycodone does?

>>>The overall feeling is very similar, but users generally feel more "tired" and "doped-up" on morphine. Oxycodone gives a very "clean high" in comparison. So morphine is similar but different.

3. Would most members of this forum prefer 80mg Oxycontin pills over 80mg morphine pills, given the oppurtunity to acquire either/or?

>>>SWIM has never heard of 80mg morphine tablets, so this sum must be quantitative. It should also be noted whether or not the tablets are Instant-Release or Timed-Release. The latter will cause all sorts of problems if insufflated as-is (ie gelling up in nostrils, less bio-availabilty etc). Either way, SWIM would choose the oxycodone even if the morphine was to be administered intravenously.

~Picass0

[swellin]

I have been using morphine for years and let me tell you right now dont ever stick morphine up your nose. It is a complete waste of the product you get much more of the pill if you take it orally. I have also been prescribed Oxycontin for the past 3 months and these drugs and identical, to me any way the only difference is that you can snort Oxy and get 80% of the pill but with snorting the pill only lasts 4 hours, if your lucky. If you take the pills orally they will last twice as long, for me i take my morphine and oxy crushed, orally and it lasts 10 hours. Also i have never heard or seen of 80mg morphine. Let me say this again do not snort morphine its a fucking waste.

[Graduisic]

Oddly enough for SWIM, his favorite is hydrocodone. morphine is great in a pinch, but can cause a lot of itching and if taking too much, vomiting. oxys are a close 2nd to hydrocodone but SWIM gets a lot more euphoria from vicodin over oxy. morphine is in the middle. so to answer the question in a long-winded way, SWIM would prefer oxy over morphine.

[JDreaming]

Milligram for milligram, oxycodone is far more potent than morphine. But they're different medicines. One of the key distinctions is that codeine/codone substances have high oral availability whereas morphine/morphone substances do not. For pain relief that you swallow, codeine/codone is generally preferred. For people who prefer to inject, morphine/morphone substances are preferred.

[RxSurf]

SWIM recently acquired 15mg CR morphine sulfate tablets. How would SWIM get the most out of these in terms of euphoria/analgesia, but still be reasonably safe? Keep in mind that SWIM does NOT snort drugs, but is open to making solutions of MS.

Also, from what SWIM has read here, it seems like SWIM should have just gotten more percocet instead...any input?

[rochepharma]

Oxycontin 80 mg aren't morphine, the main ingredient is oxycodone which is stronger than morphine, swim should lick of the coating of one of these pills and cut it in half and only snort half of it 40mg of oxycodone is great.

[LinusMundane]

SWIM prefers OC's to MSContin any day of the week, same goes for OC vs Vicodin. The other 2 do nothing for SWIM, MSContin taken orally, which is the only way SWIM has had it, made him slightly drowsy which was cool when he was going through w/d's and it was all he could find, but nothing close to what an OC would have done for him.

[tripfromthetropics]

My friend Didi Mocó once got 40mg of morphine, he first took 10mg orally, waited, and felt absolutely nothing, some days after he crushed the 30mgs and snorted it, he felt a very good and incapacitating buzz. He once snorted 10mgs and he said me it gave him a light buzz.

[oxyhydro]

Oxycodone is a lot stronger. SWIM's personal favorite is Roxicodone 30mg tabs. They are these super tiny tabs that contain 30mg oxy each and are instant release, of which SWIM recently acuired 100 of (3000mg oxycodone) for about $70 at Walgreens...

[PandorymDMT]

Originally Posted by oxyhydro

Oxycodone is a lot stronger. SWIM's personal favorite is Roxicodone 30mg tabs. They are these super tiny tabs that contain 30mg oxy each and are instant release, of which SWIM recently acuired 100 of (3000mg oxycodone) for about $70 at Walgreens...

SWIM would like to make a note for all new members here. This members discussion of prices is the most likely reason for him being banned. Don't Post Prices.

[Naked Lunch]

For the record, Oxycodone is not "a lot stronger" than morphine, it is 1.5 times as strong as morphine but has a 100% oral viability unlike morphine.

Then there's the issue of cross tolerance but it is generally accepted that oxycodone is 1.5 times the strength of morphine.


Whether injecting or dropping 100mg of oxycodone (Quite possibly a deadly dose for non tolerant people and is not recommended at all!!!)the overall effect will be the same (minus the rush, naturally).

However if one is injecting 100mg of morphine one would need to drop around 300mg of morphine to get the same overall feeling due to the poor oral viability of morphine.

Google "narcotics converter" and you can input doses of whatever you like and see the equivalents in other substances.

Besides giving this information obtained from the manufacturers and doctors and an Australian MIMS guide, swim has personal experience with both and can verify what swim just said is true and accurate.

Again, NO non-tolerant person should be taking 100mg of oxycodone, at least not as a first time or with out much smaller test doses being taken days prior to this and certainly not unsupervised!!!

[swellin]

I think you mean oral bioavailability if not my bad. And its actually 80-89% when taken orally. If taken intravenously it is 100%.

[FloatingInDreams]

Swim believes he's read somewhere that morphine is superior up to 50% when administered parenterally (I.V)
That being said swim has always had more effect personally from morphine type opioids than codeine based opioids, swim has had his fair share of feelgood from oxy's though and feels like orally they are pretty good mg for mg against most other opi's.

[Naked Lunch]

Oxycodone ins nothing like codeine.period! Its very Heroin like, (its nick name is "Hillbilly Heroin" LOL) more so than Morphine which swim considers crud and only uses it when absolutely desperate. IV Morphine feels nothing like Heroin.

People that gets kicks from codeine have zero tolerance and likely not much knowledge about narcotics either. 800mg-1Gram of Codeine is like taking an aspirin to this swimmer, it does nothing.

Codeine might be ok for kicks for newbies but it wont last long and one will require something stronger. the same can be said for Morphine, one will require something stronger, the same can be said for Oxycodone etc etc.

Heroin is the winner in this discussion ISWHIM'sO, it cant be beat!!! It never disappoints either, even after 15 years of using it!

EDIT:
As this swimmer is a long time user of Heroin and opioid in general swims advice is to never even get involved with them to begin with.Yes they are enjoyable but addiction is not an enjoyable lifestyle to most. One spends 80% of their time scamming, dealing, stealing and robbing to get $$$ for their gear, the other 20% of the time actually using the gear. The cons far outweigh the pro's. But for some, like this swimmer, its far too late to be told this or do anything much about it, the damage has been done.
Just be cautious and think twice before you get involved with opioids!!!

Reputation Comments on this post:

for disclaimer

[RxSurf]

SWIM has a strong back ground in medicinal chemistry and pharmacology.

First off, codeine is metabolized via O-demethylation followed by glucuronidation in vivo to the active form of morphine, morphine-6-glucuronide, when given orally (only about 10% though, the other 90% uses a different metabolic pathway). It is a bad drug for kicks because it causes histamine release and side affects mimic an allergic reaction. It also causes serious respiratory depression in excess doses. So, for all intensive purposes, this drug is about 1/10th as potent as morphine in delivering euphoria/analgesia to the user.

Second, oxycodone is EXACTLY as potent as morphine when given parenterally. This is because it is metabolized to the SAME active metabolite as morphine (and codeine). However, the oral to IV ratio is much lower for oxycodone, hence it works better than morphine give orally. Oral bioavailability is never 100%, but it is damn close in this case for oxycodone.

Last, stay away from these drugs unless you have a legitimate medical purpose for taking them. It's a dead end with opioids. Addiction is inevitable, SWIM has seen a lot of people get sucked into the opioid black hole, and it's not pretty...SWIMself included. Luckily, SWIM stopped/cut back before it was too late. Okay, SWIM's done preaching. Be safe, stay healthy.

Reputation Comments on this post:

accurate scientific viewpoint

[onzero]

Morphine is SHITE. Crappy dysphoric high, oxycodone comes on fast and strong and has a rush, almost a speedy effect taken orally at moderate doses, but it makes swim feel sick sometimes and is much more unforgiving.

Hydrocodone FTW.... something about vikes, they just make you feel all lovey and have a little touch of that oxy rush to them.

but yeah... they are all assholes when you stop using them.

[FloatingInDreams]

SWIM would like to know, swirx mentioned OC and M being metabolized to the same active metabolite, but swim has looked up the metabolites for both and OC metabolizes via the cytochrome p450 enzyme system in the liver, the M does not..
also OC converts in oxymorphone which is already known to be much stronger than either OC or M which could give the impression that it's stronger, Swim for some reason feels a special need to defend morphine based on it's history but is readily willing to acknowledge the superiority of stronger semi-synthetic opioids.
M6G is the main metabolite for morphine and while yes it creates more histamine release, SWIM was always under the impression that the histamine release was related to typical opioid euphoric effects?
Please enlighten swim if he is wrong and thanks for the info already posted.

[psyche]

Originally Posted by Herbal Healer 019

Morphine is only ~25% orally & I think around 40% intranasally, so obviously the oxycodone (oral bioavailability ~100%) takes the cake in terms of most doses per pill.

By quick look with google, the wikipedia and another forum which name includes a letter 'b' state that oxycodone's oral bioavailability is around 65-70%.