Inhaling - Question on using a nebulizer

[thend]

If one had a valid prescription for hydrocodone and were to use the CWE method, Would it be possible to use in a nebulizer? Perhaps in a saline or alcohol base?

thend added 1244 Minutes and 32 Seconds later...

Anyone,any ideas?

[jon-q]

Yes somebody could use his or her CWE Hydrocodone solution in a nebulizer but it wouldn’t be a very effective/efficient method of delivery.
The drug would be absorbed much quicker through the bronchial wall than it would when taken orally, but the bioavailability of the drug would be greatly reduced.
When Morphine is used in a water based nebulizer the bioavailability drops by about 70%, when compared to taken orally.
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[thend]

Please explain further why is it not more effective? Oral Ventolin dose can be like 32 mgs but when used in a nebulizer it must only be taken in micrograms. Any mist particles that make it to the lungs will be directly absorbed into the blood stream. Why would that not yield a better result? With alcohol and other products mostly taken orally, if used at that same dose in a nebulizer you would o.d. Not trying to argue I just want to know the science behind it.

[jon-q]

Not trying to argue I just want to know the science behind it

Yea no worries, if you don’t understand or disagree with any post you should challenge it, nicely of course

Oral Ventolin dose can be like 32 mgs but when used in a nebulizer it must only be taken in micrograms.

Salbutamol is a whole different kettle of fish; Salbutamol doesn’t need to enter the systemic bloodstream like Hydrocodone, it actual works directly inside the lung by relaxing the bronchial smooth muscle. Because it’s being delivered straight into the lung a smaller dose can be given. When Salbutamol is given orally higher dose tablets are generally extended relese formulations, they can also be used in patients that have other illnesses other than asthma/bronchil problems.

Please explain further why is it not more effective?

Nebulizers deliver pressurised liquid slowly and directly into the lungs, only small amounts of fluid can be SAFELY inhaled into the lungs so these machines usually have a maximum capacity 6-10mls and a maximum flow rate 0.75ml-0.25ml/m, this is where our efficiency problems begin.
Unlike metered dose inhalers nebulizers are used in cycles 2 min on 2 min off, the continuously on cycle results in mist escaping out of the facemask, even the latest hi-tech Nebulizers loose 20%-30% of product through leakage.
In theory you could turn the nebulizer on for 10 seconds and inhale then switch it off, but when the thing only pumps out 0.5ml/m to begin with it would take along time to dispense using 10 second blasts.

Any mist particles that make it to the lungs will be directly absorbed into the blood stream. Why would that not yield a better result?

Yea that’s kida true but several factors determin how efficiently and how fast they enter the blood stream, the main ones are these ~ 1) The actual size of the drug particle. 2) Molecular size and shape and weight of the drug molecule. 3) The lipid solubility of the drug. 4) Concentration of drug.
The optimum particle size for fast absorbtion in to the blood stream is 1-4 microns, anything bigger than 5 microns has difficulty sticking to the mucosal surface on the lungs, particles less than 0.5 microns like some smoke particles can get exhaled.
If the perfect profile outlined above is achieved the effects can then be almost instantaneous.
Because of the low water volume you’d be using and the solution wouldn’t even be pure Hydrocodone it’s likely the bioavailability and bang - buck ratio from Nebulised administration of CWE Hydrocodone would be low, but the onset will be quicker than when taken oraly.
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Reputation Comments on this post:

this is a great piece(s) of information, where do I start . the nebulizer is great for albuterol, not for analgesics....

[Somniphile]

Sounds risky, might irritate the lungs...