Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Opiates & Opioids
Mark Forums Read
Register Tags

Notices

Opiates & Opioids Opiates & Opioids.

 
Thread Tools
  #1  
Old 21-01-2005, 09:59
Inkmanr6 Inkmanr6 is offline
Account Awaiting Email Confirmation.
 
Join Date: 10-06-2004
Posts: 48
Inkmanr6 is an unknown quantity at this point
Points: 183, Level: 2 Points: 183, Level: 2 Points: 183, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Swim says:

I have done some opiates like Codiene, Morphine, Dilaudid, and Heroin. I haven't done anything in a month. Will my tolerance be all the way down where it was before I took anything?. I usually just go on binges.Edited by: Inkmanr6

Last edited by Helene; 23-01-2010 at 01:30. Reason: self incrimination
  #2  
Old 21-01-2005, 10:16
psychedelicgrad psychedelicgrad is offline
Account Awaiting Email Confirmation.
 
Join Date: 21-01-2005
Posts: 12
psychedelicgrad is an unknown quantity at this point
Points: 4, Level: 1 Points: 4, Level: 1 Points: 4, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Swim says:

in my experience 1-2 weeks is plenty to drop your tolerance, however, it will build back up more quickly each time around and each detox will be harder than the last. peace and love.

Last edited by Helene; 23-01-2010 at 01:31. Reason: self incrimination
  #3  
Old 21-01-2005, 16:39
Eirias Eirias is offline
Account Awaiting Email Confirmation.
 
Join Date: 21-01-2005
Posts: 476
Eirias is a decent psychonaut.Eirias is a decent psychonaut.
Points: 177, Level: 2 Points: 177, Level: 2 Points: 177, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Be careful with IV administration if you are chasing a good nod
or buzz if you have been off for awhile. Opiates are strange--
tolerance goes down in a few weeks in regard to potency, but the "high"
still may not feel as good, especially if you ever were
habituated. It's very true that a person with a long-term habit
can be completely clean for decades, and within a week of using again
they are metabolizing the opiates just like when they were previously
habituated, dopesickness and all. It's like your cells remember
what to do with the junk, even 30 years later (at least Burroughs
believes so).

If you IV, only inject one-third of the shot after you register
a vein, then after 20-30 seconds the next 3rd, then after 20 more the
rest. This is good practice also when testing out a new batch of
heroin or morphine (unless the morphine is in a standard concentation
in solution), or scoring dope from a different city, or shooting a
pharmaceutical opiate that you have not IV'd before.

Post Quality Evaluations:
Good harm reduction advice
Good harm reduction advice
great harm reduction advice

Last edited by Alfa; 09-02-2012 at 00:31.
  #4  
Old 19-09-2006, 07:19
DrMuffy DrMuffy is offline
Account Awaiting Email Confirmation.
 
Join Date: 14-09-2006
Male
Posts: 471
DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.
Points: 934, Level: 4 Points: 934, Level: 4 Points: 934, Level: 4
Activity: 0% Activity: 0% Activity: 0%
How long does it take for opiate tolerance to decrease?

This has probaly been answered b4, but anyways SWIM was wondering How fast would a tolerance build up from a user (for the past couple weeks) using vikodens 15mg, percs 10mg codeine 170mg and morphine 30mg every day. Is there is any way to decrease your tolerance, or how long you have to stop for it to go back to normal?
  #5  
Old 19-09-2006, 08:57
Forthesevenlakes Forthesevenlakes is offline
Account Awaiting Email Confirmation.
 
Join Date: 26-02-2006
Male
Posts: 2,076
Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.
Points: 2,192, Level: 7 Points: 2,192, Level: 7 Points: 2,192, Level: 7
Activity: 0% Activity: 0% Activity: 0%
tolerance would start from the very first usage of opiates, and if used daily, would build up pretty fast. it should be noticable after a few days, especially in the amount SWIY has mentioned. there is some evidence that use of DXM can decrease opiate tolerance, as can ibogaine, but ibogaine is impractical for everyday use. DXM could be used daily in 30-60 mg amounts, but only decreases opiate tolerance a small amount. at least a couple weeks free of opiates would be needed to rid oneself of tolerance, but if daily use has been going on for a couple weeks or so, it could take at least a month for it to go back to baseline. really abstinence from these drugs is the only effective, practical way to reduce tolerance.
  #6  
Old 20-09-2006, 02:08
Fantasian Fantasian is offline
Account Awaiting Email Confirmation.
 
Join Date: 27-09-2005
26 y/o Male from United Kingdom
Posts: 1,182
Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.
Points: 2,756, Level: 7 Points: 2,756, Level: 7 Points: 2,756, Level: 7
Activity: 0% Activity: 0% Activity: 0%
Quote:
Originally Posted by DrMuffy
This has probaly been answered b4, but anyways SWIM was wondering How fast would a tolerance build up from a user (for the past couple weeks) using vikodens 15mg, percs 10mg codeine 170mg and morphine 30mg every day. Is there is any way to decrease your tolerance, or how long you have to stop for it to go back to normal?
Without going too far off topic, one would want to be careful with these kinds of dosages, even for legitimate pain relief the doses your talking about when combined are very high.

Be weary of opiate addiction as opiate withdrawal is one of the most unpleasent experiences in the world. SWIF can vouch for that.

Sorry if it seems like im being overprotective it's just something worth considering. As to tolerance SWIY should leave a week or two gap between uses to keep it down and if he can't abstain from use for longer than a day or two he has issues.
  #7  
Old 20-09-2006, 03:28
DrMuffy DrMuffy is offline
Account Awaiting Email Confirmation.
 
Join Date: 14-09-2006
Male
Posts: 471
DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.DrMuffy really adds to the discussion.
Points: 934, Level: 4 Points: 934, Level: 4 Points: 934, Level: 4
Activity: 0% Activity: 0% Activity: 0%
Thanks for the advise! Yeah SWIMs gonna stop for a while and stuff. Yeah SWIM doesnt usually mix them, but SWIM doesnt mix all of those at once, SWIM just means that in a day he'll use at least two of the opiates or more.

Last edited by Forthesevenlakes; 20-09-2006 at 06:00.
  #8  
Old 20-09-2006, 13:02
Fantasian Fantasian is offline
Account Awaiting Email Confirmation.
 
Join Date: 27-09-2005
26 y/o Male from United Kingdom
Posts: 1,182
Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.Fantasian really knows their shit.
Points: 2,756, Level: 7 Points: 2,756, Level: 7 Points: 2,756, Level: 7
Activity: 0% Activity: 0% Activity: 0%
Quote:
Originally Posted by DrMuffy
Thanks for the advise! Yeah SWIMs gonna stop for a while and stuff. Yeah SWIM doesnt usually mix them, but SWIM doesnt mix all of those at once, SWIM just means that in a day he'll use at least two of the opiates or more.
No problem, thats good to hear, i was just a little worried for SWIY
  #9  
Old 20-03-2008, 05:30
Jamdan Jamdan is offline
Newbie
 
Join Date: 29-02-2008
Female
Posts: 7
Jamdan is an unknown quantity at this point
Points: 38, Level: 1 Points: 38, Level: 1 Points: 38, Level: 1
Activity: 0% Activity: 0% Activity: 0%
How long to decrease tolerance?

SWIM recently had all 4 of their wisdom teeth out and was prescribed 10 mg oxycodone 650 apap. For a week SWIM has taken them every 4 hours and taken 3 for recreational use a few times. Yesterday, SWIM found a full bottle of Norcos 10/325 and took 4 tonight. The problem is, already, SWIM isn't getting too high. How long would one have to wait before taking any more to decrease their tolerance? A week? A month? And would being on oxycodone for a week affect the tolerance for hydrocodone?
  #10  
Old 20-03-2008, 08:58
OhCasey OhCasey is offline
Palladium Member
 
Join Date: 26-04-2007
27 y/o Male from United States
Posts: 621
OhCasey is on the way upOhCasey is on the way upOhCasey is on the way up
Points: 180, Level: 2 Points: 180, Level: 2 Points: 180, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: How long to decrease tolerance?

Quote:
Originally Posted by Jamdan View Post
And would being on oxycodone for a week affect the tolerance for hydrocodone?
Yep it sure will. Swim had a surgery once not too long ago and was prescribed both Norcos (Hydrocodone 10/325) and Percocets (Oxycodone 10/325) and after taking all his Percs he could barely even feel the Norcos. Tolerence should drop noticeably in a week maybe two with little to no use of opiates.
  #11  
Old 21-03-2008, 15:06
samuraigecko samuraigecko is offline
Palladium Member
 
Join Date: 25-05-2007
Male from Earth
Posts: 1,685
samuraigecko must think in IUPACsamuraigecko must think in IUPACsamuraigecko must think in IUPACsamuraigecko must think in IUPACsamuraigecko must think in IUPACsamuraigecko must think in IUPACsamuraigecko must think in IUPACsamuraigecko must think in IUPACsamuraigecko must think in IUPACsamuraigecko must think in IUPACsamuraigecko must think in IUPAC
Points: 2,929, Level: 8 Points: 2,929, Level: 8 Points: 2,929, Level: 8
Activity: 0% Activity: 0% Activity: 0%
Re: How long to decrease tolerance?

Agreed. Oxy will only make the tolerance higher since Oxy is slightly stronger than Hydro mg for mg in PO dosages.

One agrees that a week or so should do the trick. Tolerance will drop rapidly after the half life has passed.

Hope this has been of help
  #12  
Old 17-04-2008, 00:38
kbsuperstar kbsuperstar is offline
Newbie
 
Join Date: 08-10-2007
Male from United States
Posts: 36
kbsuperstar should review received reputation comments.
Points: 114, Level: 1 Points: 114, Level: 1 Points: 114, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Opiate tolerance... how long does it last?

Anyone know how long tolerance to opiates typically lasts?

For SWIM, 20-25mg does almost no pain relief and gives little high (body only, too).

He thinks this is likely due to methadone use in the past couple months (needs at least 40-50mg for a moderate high).

Yesterday he took four 5/500mg Vicodin (typical M357s), and today SWIM tried 5 to see if he could get anything. Unfortunately, he's experienced almost nothing; slight body high, but that's it.

Even though this is occurring, it could be possible that SWIM's not feeling it because he's had some migraines almost all throughout the day for the last week. The Vicodin doesn't do anything for that, either.

So, yeah... Please and thank you
  #13  
Old 17-04-2008, 02:24
Sportsguy86 Sportsguy86 is offline
Account Awaiting Email Confirmation.
 
Join Date: 25-03-2008
27 y/o Male from United States
Posts: 39
Sportsguy86 should urgently read the rules & received reputation comments.
Points: 49, Level: 1 Points: 49, Level: 1 Points: 49, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: Opiate tolerance... how long does it last?

Tolerance to opiates drops extremely quickly after use is ceased. We're talking a small number of days (3-5) before the body loses tolerance to the drug. After a week, you will notice a significant decrease in tolerance.

That said, even after long periods opiate free, you still have raised you natural opiate tolerance due to your past use. Take a year off, and you will still have a higher tolerance than when you were 10 years old. This tolerance is generally very minimal however, and just slightly more than if you had never used.
  #14  
Old 17-04-2008, 18:14
BikerKitty BikerKitty is offline
Newbie
 
Join Date: 14-04-2008
48 y/o Female
Posts: 9
BikerKitty is an unknown quantity at this point
Points: 13, Level: 1 Points: 13, Level: 1 Points: 13, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: Opiate tolerance... how long does it last?

SWIM's doc told her that opiates block the signal to the brain from the nerves. So the nerves try to get around the blockade. This means the nerves make new routes to try to tell the brain that the body has pain. This is why when you have to go off (just did a 3 month lay off), SWIy will have more pain for a while.

SWIM thought she would die! The doc just put her on Kadian 30mg. Eeh, it's ok, but SWIM sure would like their norco's back!

Be very, very careful with the tylenol in the 5/500's. SWIy could really hurt their liver that way. Also make sure SWIy doesn't take anything else over the counter with tylenol. SWIM has never tried the CWE, but would recommend trying it. Five 5/500 means SWIy took 2500 mgs of tylenol! At once. Be careful, friend WIy!

Last edited by Helene; 23-01-2010 at 01:36. Reason: self incrimination
  #15  
Old 24-04-2008, 16:11
Psych0nautPlatinum member Psych0naut is offline
Platinum Member
 
Join Date: 27-02-2006
Male from Netherlands
Posts: 2,286
Psych0naut must mainline MedlinePsych0naut must mainline MedlinePsych0naut must mainline MedlinePsych0naut must mainline MedlinePsych0naut must mainline MedlinePsych0naut must mainline MedlinePsych0naut must mainline MedlinePsych0naut must mainline MedlinePsych0naut must mainline MedlinePsych0naut must mainline MedlinePsych0naut must mainline Medline
Points: 2,986, Level: 8 Points: 2,986, Level: 8 Points: 2,986, Level: 8
Activity: 0% Activity: 0% Activity: 0%
Re: Opiate tolerance... how long does it last?

First of all, when taken on a regular basis, the maximum daily amount of paracetamol(which is 4 grams a day) gets lower and lower, due to paracetamol build up in the bloodstream. Not only that, but paracetamol toxicity doesn't start at a certain level, it's toxic on itself, no matter how little you take. It's just that the toxicity can be neglected under a certain amount, but just like alcohol, it's toxic in any dose, but the dose is the poisen, so to speak.

Unfortunenately, the human body does not grow tolerant to paracetamols liver toxicity, but it does buildup in your system when taking it on a regular basis. When drinking alcohol on top of that, which is toxic to the liver as well, even more damage is done to the liver. It's not that such a single even would be visible under a microscope a day later, but it does build up over time, that's why paracetamol as a painkiller should be avoided as much as possible.

Don't trust a large pharmaceutical corperation when they are claiming their product is safe, all they care is their profit margins, not the consumers health .. The 4 grams per day limit is a safety margin set by the medical community, as a guideline for people who infrequently use paracetamol. When frequent dosing of paracetamol is needed to stop the pain, one should see a doctor who will switch one to a stronger and safer alternative, which can be take on a frequent base. Aspirin works fine for most people as well, and taking it once a day seriously lowers your chance of heart attacks and chronic heart problems. There are a few groups of people who should not take aspirin daily, and some people who shouldn't take it on an infrequent base either, but those people are mentioned in the patient information leaflet which comes with each pack of aspirin. One of those groups of people are pregnant women, as well as people who have lost a lot of blood and those who have a low blood pressure. This is all because aspirin makes the blood thinner and can cause blood pressure to drop. Ibuprofen can be used as an alternative for paracetamol as well, though also only on an infrequent base, as it can raise changes of a heart attack in most people, and can cause kidney damage. Though Ibuprofens safety margins are a bit to a reasonably bit higher than those of paracetamol.

Post Quality Evaluations:
great info for harm reduction. overuse of tylenol products can be fatal! Mixing with alcohol is bad news as well, thank you!

Last edited by Helene; 23-01-2010 at 01:41. Reason: deleted post quote
  #16  
Old 22-03-2009, 02:44
onzero onzero is offline
Silver Member
 
Join Date: 17-02-2009
Male from Earth
Posts: 196
onzero is captain of the psychonauts.onzero is captain of the psychonauts.
how long to reduce opiate tolerance

swim took opiates (hydrocodone & tramadol mostly) off and on for three years and never really got too much of a tolerance. lately hes been taking low doses 30mg or less 5+ dAys a week. he noticed even at moderate dosages hes havent really gotten high but has trouble sleeping and feels cold without it.

how long til he can start sleeping without it (well sleeping normally) and reduce tolerance?

no other wd to mention besides feeling bored.
  #17  
Old 22-03-2009, 17:12
returntozero returntozero is offline
Mercury Member
 
Join Date: 03-09-2008
Male from United States
Posts: 103
returntozero needs to UTFSE some more before posting.
Points: 73, Level: 1 Points: 73, Level: 1 Points: 73, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: how long to reduce opiate tolerance

donno but swim has similar experience

20-30mg of hybro just makes the work day go by so smoothly (so i have heard)

now swim took one norco and 10 mg of oxy and really isnt feeling much. swim is officially out of pills now and thinking about downing the 30mg oramorph he has been sitting on for a while...
  #18  
Old 22-03-2009, 23:07
Politicalchalk Politicalchalk is offline
Titanium Member
 
Join Date: 18-06-2007
Male from United States
Posts: 349
Politicalchalk probably knows what they are talking about.Politicalchalk probably knows what they are talking about.Politicalchalk probably knows what they are talking about.Politicalchalk probably knows what they are talking about.Politicalchalk probably knows what they are talking about.
Points: 751, Level: 4 Points: 751, Level: 4 Points: 751, Level: 4
Activity: 1.3% Activity: 1.3% Activity: 1.3%
Re: how long to reduce opiate tolerance

I posted a thread a while back, something like "How long does your w/d last?" or something. Swim personally finds about a week, but psychology plays a role too. That is, if swiy waits a day or two, the brain might psych itself up to be like "Whooooo, here it comes!"

It's a fairly low dose for withdrawl though, and gradual decreases in opiate combined with symptomatic relief (ie, loperamide for the runs, diphenhydramine to help sleep, etc etc. Those are OTC in the US, Swim's cat reports that cannabis and a benzodiazepine like diazepam or lorazepam help greatly.) Alcohol in swiy's typically higher amout helps too, Swim's cat finds it can actually somewhat stop the w/d in it's tracks for the time the it's active. Apparently, alcohol increases the number of opiate pepties in the brain, and this could explain such a mechanism. Conversely, that theoretically could prolong w/d, but Swim's got no data on hand, but the cat's anecdotal reports. He feels fairly confidant about it though, because the alcohol method has been used effectively and the peptide thing sticks out pretty prominantly to the cat.

A note of caution of course. Exercise EXTREME caution if mixing benzos and alcohol. Better to avoid the combo, but over time through the day could be OK. Check the half-life of the benzo. Also, as a general rule, getting drunk is one thing, but it's a good idea not to drink to the point of vomiting.

Finally, when titrating down, check out the thread on potentiators of opiates. Let us know how it goes!
  #19  
Old 21-01-2010, 15:29
Diamhea Diamhea is offline
Newbie
 
Join Date: 21-01-2010
27 y/o Male
Posts: 1
Diamhea is an unknown quantity at this point
Points: 6, Level: 1 Points: 6, Level: 1 Points: 6, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Regarding wait time between oxycodone use.

First off, glad to be here.

AFOAF has been taking Oxycodone fairly continually going on six months. First starting at simple 20mg doses (always intra-nasal) once or twice a week to 20mg 4-5 times a week (Starting in late September) with some multi-day Suboxone breaks thrown in for good measure. However within the last month AFOAF has been taking 40mg almost daily, peaking at a roughly 60mg daily average during about a week and a half span.

AFOAF went cold turkey last Friday after the peak, deciding that he should get back to being able to use the drug on occasion; socially if you will, without fear of debilitating withdrawal. Finally feeling normal again, AFOAF has the option to try 30mg Roxicodone. How long should AFOAF wait before use? That is, to avoid more than a slight drowsiness the next morning.
  #20  
Old 12-07-2011, 11:06
Descartesx Descartesx is offline
Silver Member
 
Join Date: 20-02-2010
Male from United Kingdom
Posts: 234
Descartesx is captain of the psychonauts.Descartesx is captain of the psychonauts.Descartesx is captain of the psychonauts.
Points: 294, Level: 2 Points: 294, Level: 2 Points: 294, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: how long to reduce opiate tolerance

^ Here is the study that Politicalchalk was referring to- http://pubs.niaaa.nih.gov/publications/arh21-2/132.pdf
  #21  
Old 12-07-2011, 11:27
n3os3n n3os3n is offline
Silver Member
 
Join Date: 07-06-2011
29 y/o Male from United Kingdom
Posts: 151
n3os3n is a decent psychonaut.n3os3n is a decent psychonaut.
Points: 186, Level: 2 Points: 186, Level: 2 Points: 186, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: how long to reduce opiate tolerance

Quote:
Originally Posted by psychedelicgrad View Post
Swim says:

in my experience 1-2 weeks is plenty to drop your tolerance, however, it will build back up more quickly each time around and each detox will be harder than the last. peace and love.
Would you say this is a figure relative to people as a whole or just to a majority / select percentage of the population?

I can take opiates twice in a week, week in week out, without seeing a loss of effect or dependance (mood swings, cravings for more etc).

That said, I take them pretty much religiously and have at times upped the dose. However I can continue with my usual dosing and as long as I don't exceed twice per week, I seem to get no withdrawal or cravings.

Anyone got any info on studies for genetic / predisposition differences with opiate tolerance / withdrawal ?

Will UTFSE now but it's relevant to this thread
  #22  
Old 17-08-2011, 05:36
crazieindian crazieindian is offline
Newbie
 
Join Date: 17-07-2011
33 y/o Male from Canada
Posts: 2
crazieindian is an unknown quantity at this point
Points: 6, Level: 1 Points: 6, Level: 1 Points: 6, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: how long to reduce opiate tolerance

I'm new to this and don't realy no how to use this site or if u guys are getting what I'm writing I. Have some questions my tolerance is through the roof I've been on opiates for8 years and am taking 270!to300 mg of oxycontin a day and sometimes it feels like I took nothing and I have had a bad problem in the past with ivinng it need to know what Ivan do to rapidly decrease my tolerance I'm already met a new doctor that is weaning me off completely and then start me back on a low dose and change it every week so irony get to use to it so what can idoonthe mean time without having to go through severe withdrawal s
  #23  
Old 31-08-2011, 16:57
backpain backpain is offline
Newbie
 
Join Date: 30-08-2011
33 y/o Female from United States
Posts: 9
backpain is an unknown quantity at this point
Points: 11, Level: 1 Points: 11, Level: 1 Points: 11, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: how long to reduce opiate tolerance

AFOAF is concerned about tolerance, having been prescribed norco 2x daily for about a year now for substantial back pain. Now AFOAF is not taking a high dose of norco (only 10 mg daily) but has noticed that the pain relief only lasts about two hours at most and is afraid to tell AFOAF's doctor, for fear of being taken off the drug completely.
AFOAF was prescribed tramadol before as well, which worked somewhat but was exacerbating AFOAF's chronic migraines--so switched back to norco.

AFOAF wants to try weaning off for a few days so that the tolerance drops, but she knows from past experience how rough that will be. (Apologies to the other members who may laugh at AFOAF's addiction since it's not a high amount of hydrocodone).....
  #24  
Old 05-09-2011, 01:13
TheSweetPea TheSweetPea is offline
Silver Member
 
Join Date: 04-02-2010
Male from United States
Posts: 88
TheSweetPea is a decent psychonaut.
Points: 279, Level: 2 Points: 279, Level: 2 Points: 279, Level: 2
Activity: 0.2% Activity: 0.2% Activity: 0.2%
Re: how long to reduce opiate tolerance

SWIM notices after 5 days his tolerance drops significantly. But as stated after using for 2 days his tolerance is right back to point A
  #25  
Old 24-10-2011, 18:26
Dani723 Dani723 is offline
Newbie
 
Join Date: 01-08-2011
28 y/o Female from United Kingdom
Posts: 34
Dani723 is an unknown quantity at this point
Points: 90, Level: 1 Points: 90, Level: 1 Points: 90, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: how long to reduce opiate tolerance

My friend's noticed that she simply cannot use opium two days in a row and get anything worthwhile out of it. She might take a week off and the first day back would be a good experience, and the second day a write-off.

She's wondering what the scientific explanation is for quickly falling and quickly rising tolerance, and whether this is the norm for opiate users.

Now that she knows to not use multiple days in a row, she's experimenting with opiate breaks, and finds so far that 3 days is not enough, perhaps because of how long opium stays in the system, but 5 day breaks are MUCH better, and 4 days off is the bare minimum for it to be worthwhile.

Now she's taking her first break, having used opium inconsistently for the last few months, and never having tried it prior to that. She's not had any kind of withdrawal symptoms at all during her experimentation, with usage ranging from every day of the week to once per week and everything in between.

Once every 5 days seems to be the magic compromise for her. This quickly building tolerance is a blessing in disguise that will save some of us from physical addiction!

She's going to try hydrocodone next, as she can't sleep on opium, perhaps the same usage pattern will work?

Share this on:

Tags
addiction, alcohol, analgesic, aspirin, drugs, morphine, narcotic, norcos, opioid, opium, oxycodone, pain relief, paracetamol, roxicodone, suboxone, toxicity, tylenol, withdrawals

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Pharmacology - NMDA Antagonists and tolerance medievil Various drugs not covered by other forums 10 02-01-2014 16:46
Mechanisms of opioid-induced tolerance and hyperalgesia (2007) Paracelsus Pharmacology 1 11-06-2013 23:21
Dose - for those with an opiate tolerance, how many pods per serving do you need average? oneeno Opium & Poppy 7 12-12-2009 06:30
Drug info - Using naltrexone between opiate doses to reduce tolerance cybergenesis Opiates & Opioids 2 15-12-2008 15:38
opiate tolerance - how long to establish? (not the usual ?) kailey_elise Opiates & Opioids 2 17-04-2006 21:52

» New Threads
odd question, Can someone tell me...
Last post by nightprowler
0 Replies, 1 Views
Hydroxyzine + Diphenhydramine...
Last post by XTC_Rob
0 Replies, 1 Views
E-Cigarettes?
Last post by Trying Again
88 Replies, 25,211 Views
Dipping at Family Gathering
Last post by Drugfreekid
1 Replies, 14 Views
What was your first...
Last post by Trying Again
11 Replies, 226 Views
Seizure on dxm
Last post by Serpentaxt
5 Replies, 207 Views
Over dose or over did it?...
Last post by Adirondack
3 Replies, 66 Views
Need help with...
Last post by Sweeny
0 Replies, 34 Views
Addicted to Loperamide-New Year,...
Last post by Nefret
95 Replies, 4,595 Views
Dispelling the Codeine "Ceiling...
Last post by Petri6
8 Replies, 290 Views
» New Wiki Articles

Sitelinks: Information:

All times are GMT +1. The time now is 06:04.


Copyright: SIN Foundation 2003 - 2014, All rights reserved
"Wiki" powered by VaultWiki v3.0.20 PL 1.