Drug info - Imidazenil - a non addictive benzodiazepine?

[riaahacker]

I've been interested in researching this benzodiazepine for awhile. It is anxiolytic and produces anticonvulsant effects without the sedative and amnesiac effects of other benzodiazepines. Imidazenil even reversed the sedation caused by diazepam. One very interesting thing is it hasn't been shown to cause tolerance of dependence which make a very interesting agent indeed. Anyone have anymore information on this drug?

midazenil is a GABAA partial agonist[1] with an unusual profile of effects, producing some of the effects associated with normal benzodiazepines such as anticonvulsant and anxiolytic effects, yet without any notable sedative[2] or amnestic[3] effects. In fact, imidazenil blocks the sedative effects of diazepam, yet without lowering the convulsion threshold,[4] and so potentially could be a more flexible antidote than the antagonist flumazenil which is commonly used to treat benzodiazepine overdose at present.

This unusual profile of effects makes imidazenil potentially a very useful drug. In animal studies it has been shown to be an effective anxiolytic and strong anticonvulsant, yet without many of the side effects associated with other benzodiazepines; it does not produce tolerance[5] or dependence,[6] reverses the amnestic effects of conventional benzodiazepines, and does not potentiate the effects of alcohol.[7][8]

wikipedia