Injecting - is injection safer than oral use?

[shanesmith7]

if the metabolites are theoretically the neurotoxic factor associated with mdma would injecting it directly into the blood stream get pure mdma into the brain? or is their some kind of in vivo metabolism that would be in effect? and if the liver is where these metabolites become apparant, could changing my liver get pure molly to my brain?

[Ilsa]

in short, absolutely not.

try a search, here's a thread to get started:
http://www.drugs-forum.com/forum/arc...hp/t-7171.html

remember to use SWIM consistently. imho, it's highly dangerous to inject mdma, as it is so rarely pure, and because of the risks inherent in shooting. rectal admin would be more advisable, crazy as that may sound. one wouldn't have to be so concerned about cut damaging the veins, and hell, if one is willing enough to bypass ALL of the body's front lines of defense against infection, and stick a needle in a vein, one would be willing to entertain such an alternative? almost the same bioavaiability, not nearly the risk. dosing should be started low and raised if one wanted to hypothetically try this method (bioavailability again).


swim will say, in her experience with injecting, that injecting mdma tabs did not work well. she is now fairly certain that they were not the best pills, but it was a deumb idea to begin with....it's hard to inject the amounts of water needed (at least with this batch) to fully solvate the pill, and she had to inject several times to get the full dose, because of the large amounts of solvent needed. this was only once, at the height of her iv use, but she thought it worth including.

[Readux]

theoretically yes, but in reality no

[nibble]

Originally Posted by shanesmith7

if the metabolites are theoretically the neurotoxic factor associated with mdma would injecting it directly into the blood stream get pure mdma into the brain? or is their some kind of in vivo metabolism that would be in effect? and if the liver is where these metabolites become apparant, could changing my liver get pure molly to my brain?

To my knowledge it's not the metabolites of MDMA that are what appear to produce "neurotoxicity" but rather it is simply the consequence of having very high levels of monoamine neurotransmitters (dopamine and particularly serotonin) present in the synapse. These large amounts must undergo metabolism and in doing so will inevitably create "free radicals", these are highly reactive molecules that essentially tear apart neurons in an attempt to stabilise the molecule. The ROA can't avoid this it is simply as a result of the drugs effects. Actually if anything IV'ing would increase the damage potential as you would get very high levels of the neurotransmitters in question in a very short time-frame and thus not give your body a chance to prevent some of the potential damage.

[Ilsa]

the toxicity associated with mdma is actually a function of serotonin depletion....certain serotonergic (serotonin-producing) cells in the brain, particularly those found in bundles of neurons called the raphe nuclei, are dependent on the presence of serotonin to survive. without it, they self-sacrifice in a process called apoptosis. since mdma floods the brain with serotonin, these cells (which supply some of the released mdma) can becomed serotonin-deprived for too long, inducing cell death.

so shooting has little bearing on neurotoxicity, it's more to do with duration and amount used.