Combinations - LSD and Salvia - a word of warning

[Rapid Dave]

My pet lizard procured some LSD the other week and he and a reptilian friend dropped a tab each last Friday. He reported that it was pretty potent but gave a fantastic plateau-ing high, with all the effects one would expect from decent LSD.

The following night, he and some other of his lizard friends got some Salvia.

Whilst being an experienced recreational drug user of several substances, both on their own and in combinations (for example, he had a great previous experience whilst candy-flipping), he has told me that he won't do the combination in such close proxmity again... and perhaps never use Salvia ever again.

Basically, the Salvia was 40x strength and his first toke gave a really mild effect (he said it was nice, but was expecting more of an intense yet short-lived high).

The 2nd hit contained a larger quantity than the first and sent him in into a fit of most enjoyable giggles and non-sensical verbal outbursts.

However, shortly after, an intense feeling of disembodiment and extreme discomfort overtook when he freaked out for a couple of minutes. Whilst gradually gaining awareness (as one would expect), throughout this period he genuinely thought he had caused permanent damage to his brain... this coming from an experienced drug user who manages to both enjoy the highs he has and still maintain a healthy degree of control.

Whilst not a neuroscientist, he wonders if the Salvia re-activated some residual acid that was in his system.

I'd first like to warn those people who have pets lizards who use these two drugs about not using them in in short periods of time, and to ask anyone else if their pets have experienced any similar experiences with these two sustances.

Finally, he tells me that he's learned a valuable lesson!

[Shampoo]

Salvia would not have activated any "residual" LSD, that is not how LSD works, nor is it how Salvia works. Furthermore, LSD and Salvia work through entirely different neurotransmitter systems. The active ingredients in salvia activate Kappa-Opioid receptors while LSD acts as an agonist for 5-HT receptors. There is no reason that taking LSD should upregulate or otherwise sensitize kappa-opioid receptors.

The paranoia, dysphoria, and depersonalization that your friend reports experiencing are all common effects of kappa-opioid receptor activation. I highly doubt they had anything to do with the previous day's adventure.

[Rapid Dave]

OK, well he says thanks anyway.

The lesson for people's pet lizards is probably not to do 40x strength Salvia on their first go, then!

[cra$h]

oh, this was swiy's first salvia trip? no wonder why it wasn't pleasant. Salvia's in swim's top 5, and was considering hitting some 60x while on lsd, if the lsd isn't potent enough already (swim's never done lsd) and would imagine it being quite a brainfucking trip, but very.......divine......

[Rapid Dave]

Originally Posted by cra$h

oh, this was swiy's first salvia trip? no wonder why it wasn't pleasant. Salvia's in swim's top 5, and was considering hitting some 60x while on lsd, if the lsd isn't potent enough already (swim's never done lsd) and would imagine it being quite a brainfucking trip, but very.......divine......

Well strangely enough, there's a extensive audio recording of the evening's Salvia experience and just after my pet lizard took his 2nd hit, all you can hear is a blood-curdling scream of "I DON'T FUCKING WANT TO BE LIKE THIS ANYMORE... SOMEBODY HELP ME!!!"

He tells me that, after a couple of minutes, he started to return to normal but still thought he'd damaged his brain!

And this coming from a reptilian well-versed in coke, MDMA, weed, LSD and mushrooms. He also says that, in a way, he's gald that this happened so that he doesn't get so complacent and knows his limits.

Still thinks that he won't do Salvia again, though!