Health - Counteracting cocaine erection issues by inhibiting the action of adrenaline?

[motile]

Hi folks.

This is my first real post outside the intro pages so be patient

Swim suffers, like so many others, with severe cokedick. A few lines and it requires viagra (or to be more precise the generic Indian version called Kamagra, as it's stronger and far cheaper) to achieve an erection. After a gram of toot and even the Kamagra stops working well and it requires hard concentration and no distractions to achieve an erection. But why? Why does Swim's undercarriage react in this way? Well after looking into it I have formulated a decent enough hypothesis.

Cocaine, we all know, stimulates the cardiovascular system. It gets the heart pounding. It does this by blocking nonadrenaline uptake in the nerve endings while simultaneously dumping nonadrenaline and adrenaline into the nervous system. Once adrenaline and nonadrenaline are released from the adrenal glands several things will occur...

Adrenaline and nonadrenaline are in charge of making some of the smaller blood vessels close up while it makes the blood vessels in the liver and the skeletal muscles wider. By making the less important blood vessels smaller, and opening up the more important blood vessels, a better blood flow is created. With this better blood flow towards the skeletal muscles and liver, the muscles and liver will be able to function to their highest ability do to the increase in oxygen that they are receiving. The nonadrenaline, like adrenaline, constricts blood vessels too but the difference between the two is that the nonadrenaline constricts almost all the blood vessels while the adrenaline only constricts the less important ones. This is commonly known as the flight or fight reflex.

The subsequent build of of adrenalin, nonadrenaline and the fact that nonadrenaline isn't being mopped up means that the flight or fight reflex of shutting down non essential systems becomes extreme and powerful. This leads to your feet feeling chilly and after a while your penis, starved of the blood supply, shrivels up and becomes far less sensitive and hey presto! Cokedick.

This my friends is the real reason behind cocaine driven erectile dysfunction. This is why after a while erectile function returns to normal as the body gets rid of the excess adrenalin and nonadrenaline.

With this as a basis has anyone got any theories as to how SWIM could counteract the effects of the adrenalin in the system. I have been looking into beta blockers as they inhibit the distribution of adrenalin but this is nowhere near being a valid hypothesis until it is clear what effects, if any, beta blockers would have on the ride.

Mote'.

Reputation Comments on this post:

	A very interesting thesis and one of the most interesting OP's I have seen. The only thing missing is a request for opin...
	I like your thread and because it contains pretty accurate information on why erections become harder ( no pun intended)...
	very interesting approach to the issue, focusing on the initial cause. not exactly sure that the fight /flight reflex co...
	Awesome post. Swim is obsessed with figuring out more and more about sex and snow

[radiometer]

Cocaine and beta-blockers are specifically contra-indicated. I am certain that I have posted this information in other threads, as well.

Beta blockers must not be used in the treatment of cocaine, amphetamine, or other alpha adrenergic stimulant overdose. The blockade of only beta receptors increases hypertension, reduces coronary blood flow, left ventricular function, and cardiac output and tissue perfusion by means of leaving the alpha adrenergic system stimulation unopposed.

http://emedicine.medscape.com/article/165716-overview

I suspect that what you're hoping to do here is a complete and utter impossibility, and that any attempt SWIY makes to solve this with pharmacology will be, by default, extremely dangerous.

Reputation Comments on this post:

thanks for the input and the much appreciated link

[motile]

Before I start, again, I just want to mention that when I tried to post a reply without removing your link to emedecine I lost the whole post I had been writing for the past half hour because, in an effort to reduce spam, only posters with 50 posts can post links. Ergo this version won't be nearly as detailed as the version I just lost because I do not have the time.

Originally Posted by radiometer

Cocaine and beta-blockers are specifically contra-indicated. I am certain that I have posted this information in other threads, as well.

I agree, many medical trials and studies specifically forbid the use of beta-blockers in conjunction with cocaine however they all have something in common, as does your quote from wikipedia. They all deal with treating overdose and/or heart/blood pressure problems, usually including chest pain. I fully agree that alpha adrenergic stimulant overdose should not be treated with a substance that 'increases hypertension, reduces coronary blood flow, left ventricular function, and cardiac output'.

With that said I am not suggesting that hypertensive crisis should be treated with beta blockers. If SWIM is having a hypertensive crisis or has any other heart problems then achieving an erection should be the last thing on their mind as sex would probably kill them.

Originally Posted by radiometer

I suspect that what you're hoping to do here is a complete and utter impossibility, and that any attempt SWIY makes to solve this with pharmacology will be, by default, extremely dangerous.

I disagree that what I am suggesting is impossible as reducing the action of adrenalin is something that is done for other reasons medically every day. I do not think that finding a pharmacological solution is, by default, as extremely dangerous as say using cocaine itself. Although I wonder if you have misunderstood the question I am asking? I do not want to halt the bodies production of adrenalin and I do not want to put extra strain on the heart. I am seeking a way of reducing the action of adrenalin once it is already distributed and thus halting or reducing the fight of flight reflex of shutting down non essential extremities.

From the same wiki article you quoted:

The physiological symptoms of the fight/flight response associated with performance anxiety and panic (pounding heart, cold/clammy hands, increased respiration, sweating, etc.) are significantly reduced, thus enabling anxious individuals to concentrate on the task at hand

This seems to be the desired result, to significantly reduce the effects of a large increase in adrenalin.

Are there alternatives to beta-blockers that would do the same job? Would using beta-blockers in conjunction with small to moderate amounts of cocaine (1-3 grams in a night) whilst having NO other health problems at all have the same dangers as someone who is suffering cocaine induced heart problems, overdose or hypertensive crisis? SWIM doesn't think so but SWIM is not betting their life on an assumption, SWIM needs factual data.

[Flavio]

Hi! Thank you for posting this question, it's really, really important.

I don't do any drugs, but I've always suffered from 'sexual performance anxiety', so I would also like to know how to stop the negative effects of adrenaline (fight-or-flight response).

You mentioned beta blockers but one of the side effects associated with them is... loss of erection.

Alpha blockers, by the contrary, could be helpful. Phentolamine mesylate, an alpha blocker, is prescribed for the treatment of less severe cases of ED. Phentolamine controls the erection process through the body's sympathetic system allowing blood to flow into the penis to form an erection.

I have ordered phentolamine (brand names VASOMAX, VIGAMED) and I have tried it once with good results, but it's still too early to consider it a complete success.

Any other ideas, guys?

(If you have any suggestions, please send me an e-mail or a PM, this is really important to me. My e-mail: metropolis57@hotmail.com)

[Benga]

Originally Posted by Flavio

Alpha blockers, by the contrary, could be helpful. Phentolamine mesylate, an alpha blocker, is prescribed for the treatment of less severe cases of ED. Phentolamine controls the erection process through the body's sympathetic system allowing blood to flow into the penis to form an erection.

why not go for sildenalfil or similar in this case ?

[Flavio]

Originally Posted by Benga

why not go for sildenalfil or similar in this case ?

Good question.

Sildenafil (Viagra) and tadalafil (Cialis) are very effective and, because they improve erections and make you more confident, they could be helpful in cases of psychogenic ED. They are not, however, anxiety drugs. You could take Cialis, have a great erection and then boom - anxiety gets in the way and adrenaline makes you lose your erection (this has happened to me twice).

Phentolamine, by the contrary, blocks the sympathetic nervous system (this is the one that screws your erections and controls ejaculation) and doesn't affect the parasympathetic system (the one that controls erections). That's my theory, at least.

There is one problem, though: because phentolamine blocks the sympathetic nervous system, it can delay your ejaculation a bit (although this could be a god's send if you suffer from premature ejaculation).

Flavio added 6 Minutes and 15 Seconds later...

Originally Posted by motile

[...] (or to be more precise the generic Indian version called Kamagra, as it's stronger and far cheaper) [...]

Interesting.

I have tried Viagra before with excellent results, but kamagra is still a big mystery to me. Is it effective and safe? I don't trust generics, especially if they're made in India. When it comes to my health, I don't take any chances - even if that means paying a few extra $$$.

[Ashley1717]

SWIM has encountered many "CLIENTS" when on cola can not perform the way they should be it doesnt matter to me I'm compensated either way but ive personally experienced it probally 15 times

[Riverhead]

Originally Posted by Ashley1717

SWIM has encountered many "CLIENTS" when on cola can not perform the way they should be it doesnt matter to me I'm compensated either way but ive personally experienced it probally 15 times

Is SWIY a prostitute?

[Riverhead]

please respond