Drug info - Tussionex

[rysko]

Hey swim has been doing a lot of reading on this website regarding tussionex. Seems to me that a lot of people are saying it's not that great. Swim has fairly bad anxiety and out of every drug swim has tried tussionex is the all time favorite. It was like liquid gold. Made swim feel like he was king of the world. Compared to hydro cordon pills, up to 80mg of oc, codein + promethazine, weed, h, everything nothing has ever compared. Swim is wondering what is the reason for this or if anybody has any knowledge. Thanks a lot.

[RX420]

isn't that just codeine with gufesiaan (sp?) my sisters bf will chug a bottle of cherratussin. is that the same??? it seems weak from what the ingredients say.

RX420 added 1 Minutes and 51 Seconds later...

ok after some research swim see its Hydrocodone and Chlorpheniramine. couldnt swiyou just take some norcos and antihistamine pills for the same effect???

[Swing]

NOOOOOOO TUSINEX sucks swim they outlawed all the great hydocodone cough syrups and now all that's left is TUSSINEX swim just recently bought a bottle and it's 100 dollars if you don't have insurance or 40 dollars for a copay. Plus that it is time released. swim used to be able do drank a quarter bottle of that stuff and feel GREAT FOR A LONG TIME on the old hydrocodone cough syrup but this new stuff is time released and swim drank an ENTIRE bottle and felt nothing close but to a mildly mildly euphoric feeling for a medium duration. Luckily in WA state swim can buy a bottle of codeine cought syrup behind the counter without a script which in swim's opinion is a cheaper and better a way better investmennt, minus the taste.

[rysko]

swim doesn't understand why tussionex affects him so wonderfully its strange he absolutely finds it better than anything else he's ever had

[RX420]

all that antihistamine potentates opiates, but it cant be good for swiyou im sure...

[JarvyJarvison]

Please elaborate on what drugs are in the syrup.

[lalaland12]

Originally Posted by rysko

swim doesn't understand why tussionex affects him so wonderfully its strange he absolutely finds it better than anything else he's ever had

tussionex was amazing until PEEP tried roxy's... still a bottle of tussionex still is nice when she can't find any roxys or opiates pill form.

[purplehaze]

Yes tussionex is Hydrocodone and Chlorpheniramine. Chlorpheniramine is one of the bad C's and its dangerous to take a a lot of this. The antihistamine potentiates the high of the hydrocodone and the time release could cause a user with little body mass and low tolerance to be in serious danger of their health. Drinking a whole bottle hypothetically would most likely cause extreme discomfort and a mild to serious overdose. Vomiting, blacking out etc. *if a blackout occurs swiy will most likely have nightmares and lucid dreams

Most of the tussionex Phaze has encountered has been 5 ml has 10 mg of hydrocodone, and ~60 mg hydro per oz. Around 20 mg of hydrocodone is a recreational dose for those without tolerance. It being potentiate by a dangerous antihistamine could cause serious problems for the uninformed user. I have no idea why they put antihistamines like this in things that people are prone to abuse. Trying to kill them is a little extreme way to prevent things from happening.

Phazes experience with this however has been pretty good. A warm comfortable feeling comparable to the social comfortability felt when drinking, but overall euphoric and happy. Music was enhanced and the time spent feeling the effects were enjoyable to live life.

[Bajeda]

Tussionex is interesting, as it uses polistirex coatings to make the drugs release over an extended period of time. The hydrocodone and chlorpheniramine don't hit you all at once, but are released over a 12 hour period.

Its important to keep in mind that the addition of the anti-histamine chlorpheniramine produces stronger sedative effects, and one should aim for a lower than usual dose of hydrocodone because there will be synergistic effects between the two substances. This is especially true if one hasn't tried this syrup formulation before and isn't sure how sensitive they are to the mixture of the two substances.

[Politicalchalk]

Opiates are known to have an anxiolytic affect in some people, and the time release (as SwiBajeda points out), is an interesting one. Remember, the balancing salt isn't bitartrate, like in pills, so the way (in addition to the release system) is gets absorbed is somewhat different. In other words, that long, 12-hour release mechanism provides the anxiety relief for an extended period, as Swiy describes.

[Bajeda]

Prescribing information attached.

Tussionex-Prescribing-Information.pdf



Some facts about pharmcokinetics:

Hydrocodone mean (S.D.) peak plasma concentrations of 22.8 (5.9) ng/mL occurred at 3.4 hours.

Chlorpheniramine mean (S.D.) peak plasma concentrations of 58.4 (14.7) ng/mL occurred at 6.3 hours following.

The plasma half-lives of hydrocodone and chlorpheniramine have been reported to be 4 and 16 hours respectively.



Also worth noting is the fact that Chlorpheniramine is an SSNRI; it selectively inhibits the reuptake of both serotonin and noradrenaline. Therefore, users of Tussionex may notice anti-depressant qualities to the medicine, though I am not sure how quickly chlorpheniramine acts on 5-HT receptors. It may be rapid acting like Tramadol, with mood enhancing effects occurring shortly after ingestion; or it may need to build up over time before effects are noticed, like most traditional SSRIs.

You should be extra careful taking recreational doses of Tussionex if you are currently on any SSRI or SNRI medication, due to the chance for additive effects, perhaps leading to Serotonin Syndrome, or resulting in other undesirable consequences.


If you haven't taken chlorpheniramine before, be sure to start out with a low dose to start. You want to make sure you are not allergic to it. Beyond that, you also want to evaluate your sensitivity to the substance and become familiar with its effects in combination with hydrocodone. If you are especially sensitive to the side effects of chlorpheniramine you might not be able to take higher doses.

Its not a good idea to combine other substances with Tussionex. Additional CNS depressants can have unpredictable synergistic interactions with the hydrocodone-chlorpheniramine combination, and increase the risk for serious respiratory depression. Stimulants are also risky. MAOIs should also be avoided.





A certain panda has come to like Tussionex. It induces substantial euphoria, and is far more stimulating than hydrocodone alone. The last time the panda used it, he was bounding about with frenetic energy for hours (with redosing). He couldn't sit still for long, he had so much energy he just had to go skipping about the house every so often. The prominent mood lift was also very welcome; it reminded him of Tramadol, which also tends to get him cheerful. The panda feels this is much more worthwhile than Hydromet / Hycodan syrup formulations, most certainly due to the addition of the chlorpheniramine instead of homatropine, though the time release polistirex coating may also play a contributing role.