Pharmacology - APAP interfiering with codeine-morphine convertion???

[RoboCodeine7610]

Does anyone think that Paracetamol could interfere with codeine'
s metabolism into morphine?Take a look at this:

Paracetamol:

Production of NAPQI is due primarily to two isoenzymes of cytochrome P450: CYP2E1 and CYP1A2. The P450 gene is highly polymorphic, however, and individual differences in paracetamol toxicity are believed to be due to a third isoenzyme, CYP2D6. Genetic polymorphisms in CYP2D6 may contribute to significantly different rates of production of NAPQI. Furthermore, individuals can be classified as "extensive", "ultrarapid", and "poor" metabolizers (producers of NAPQI), depending on their levels of CYP2D6 expression. Although CYP2D6 metabolises paracetamol into NAPQI to a lesser extent than other P450 enzymes, its activity may contribute to paracetamol toxicity in extensive and ultrarapid metabolisers, and when paracetamol is taken at very large doses

Codeine:

The conversion of codeine to morphine occurs in the liver and is catalysed by the cytochrome P450 enzyme CYP2D6. CYP3A4 produces norcodeine and UGT2B7 conjugates codeine, norcodeine and morphine to the corresponding 3- and 6- glucuronides.

Could the APAP be interfering with the codeine-morphine convertion?It seems like it's possible, what do you guys think??Any pharmacological experts around??

[Tussipax]

Swim doesn't know in fact but swim knows white pomelo juice increases the purcentage of codeine which is transformed into morphine.
Swim has already tried it and it works really well.

[RoboCodeine7610]

Swim doesn't know in fact but swim knows white pomelo juice increases the purcentage of codeine which is transformed into morphine.
Swim has already tried it and it works really well.

And so does grapefruit juice, there's already a huge thread in the forum about that.

[Tussipax]

Originally Posted by RoboCodeine7610

And so does grapefruit juice, there's already a huge thread in the forum about that.

Yep, I've juste read it !

[oxyhydro]

No it wont interfere enough for anything to be noticeable, unless you take a crap load of acetaminophen and get sick from it.