Health - Mephedrone: Potential Neuropathy - Extreme side effects. PLEASE READ

[dadrone]

Yes, I am fully aware there is a separate page for mephedrone experiences by SWIMmers. However, since my imaginary talking rabbit has experienced a potential toxic effect from mephedrone, I thought it best to make a new post so it could be read by any seeking information on this.

It's too soon to tell if this is permanent, or merely a really, really fucking scary transient effect, but my rabbit has lost the ability to raise his left foot (dorsiflexion, if anyone here has anatomy/medical knowledge). He can raise himself on the balls of his left foot, which is plantarflexion, the opposite motion for feet, but he cannot pull his foot up towards his body.

The top of his foot is numb-ish, as is part of his ankle/lower leg. He can't tell if it's gotten any less so with time. SWIM does not know if it is against forum policy to report the duration of time that has elapsed between the last dose of mephedrone and the present, so he will not. It hasn't been long, that's all he'll say.

If anyone has had similar experiences and they turned out to be transient, please tell my rabbit, because it will ease his mind considerably. His walking gait is, for the most part, almost unaffected, though he has to put a little more thought into where he's putting his left foot. Driving (even a stick shift) is no problem, and he will experiment with riding a bike in the future. However, he tried running, and nearly broke his ankle. He is not looking forward to the prospect of being permanently, albeit mildly, disabled, especially from something as stupid as drug use.

The Wikipedia article for mephedrone lists "occasional reports of body numbness and lack of tactile sensitivity for very large amounts". My rabbit doesn't know if approximately 660 mg of mephedrone, in 100-150 mg doses, over the course of about 10 hours, is a "very large amount", or if "body numbness and lack of tactile sensitivity" is really that accurate a description for his horrifying new development, but he's hoping, because the article seems to suggest that such things are temporary.

Apparently I can't link directly to sites yet but my rabbit tells me his symptoms are very much like foot drop, if you feel like looking that up.

If this is a totally new phenomenon (hooray for SWIM ), let it be known that this compound may have serious potential for peripheral neuropathy.

There is one hope with the latter, it seems. We're probably all aware that our good friend ethanol is known for peripheral neuropathy. Apparently, at least as far as SWIM can tell, ethanol-induced neuropathy can improve, with time, once ethanol consumption is eliminated. Since my rabbit is never, ever going near this terrible chemical (or anything else, for that matter...) ever again, maybe it will improve, in time. (Sure.)

My rabbit did redose a number of times. As has been said before, the draw to do so is ridiculously strong, perhaps more so than anything my rabbit has tried before. He wrote an experience report he hates himself for writing due to it being positive towards mephedrone; this report need not be shared.

However, it is interesting to note that the numbness was noted in the report at the ten-hour mark, suggesting that any potential neuropathy induced by this compound may be due to metabolites, not the compound itself.

Any information would be welcomed. Please be careful with this awful substance. The only positive to be found from this nightmarish experience is that my rabbit has finally realized, although perhaps too late, that no transient state of consciousness-expansion or euphoria is worth risking one's ability to do really simple things like walking or running.

Hopefully, no one reading this has ever or will ever have to deal with the knowledge that you might not be able to move freely, as you have always done, and which you have always taken for granted, ever again.

Oh, and my rabbit is quite impoverished, and his medical insurance is utter shit, so he won't be able to visit a doctor for quite a while, in case anyone asks.

Reputation Comments on this post:

	Thank you for posting this in the interest of harm reduction, swim will research this
	valuable info RE potential adverse effects. A good warning.
	Good post its good to share the pain as well as the pleasure

[dr. swim]

It could've been something your rabbit did while on the drug that caused the problem. Was your rabbit putting any sort of physical strain on his foot, like dancing around really fast for long periods of time? I've heard that people do that a LOT when on this stuff...and then the next day they barely remember anything and they're all sore and bruised.

[foxydoe]

Heard reports of pronounced vasoconstriction. It may be possible the blood flow was cut off enough to inflict damage.

[Synchronium]

Ischaemia would hurt rather than feel numb.

[Synesthesiac]

You generally cant move your foot upward towards yourself anyway, I can only move it 90 degrees max. Kind of what feet are intended to do.



......It was likely some acute vasconstriction which cut some blood flow to the extremities and resulted in some temporary weakening of muscles. Coke does this too. One of swims friends did WAY too much and got severe vasoconstriction (or an auto-immune response, no-ones quite sure, thread about it here http://www.drugs-forum.com/forum/showthread.php?t=72861) And he had done about 15 grams of meph in a month, and once did two whole grams in a day, so dont worry, what you did is very meagre compared to some fools! Its very common to suffer postural hypotension after using drugs like this, which can leave people feeling very faint and weak from drop in blood pressure for a few hours, sometimes a day or so. Also it can speed up your metabolism and stop you eating, so you likely were weak from malnutrition aswell.

Hope alls well now. Please post back and say.

[holdout]

+1 from SWIM!!!!! Well, not exactly, but SWIM has been getting some real bad cyanosis in fingernails/toes with every meph session. (Like that kid that was hospitalized and their story made it to the media, except they turned realllyyyy blue and had red rashes too). Last night SWIM took ~180mg of mephedrone and noticed intermittent pain in their left foot!

SWIM is going to the doctor because they are having neuralgic-type pain in the left side of their head sometimes. Sometimes a numbing sensation on the left side of their scalp. (But then again, SWIM is also known to have combined mephedrone with with 5-HTP, St. John's Wort, and Vitamin B6, all at once, which is HIGHLY not advisable).

So please, REMEMBER that mephedrone is a RESEARCH chemical.

[foxydoe]

Originally Posted by holdout

+1 from SWIM!!!!! Well, not exactly, but SWIM has been getting some real bad cyanosis in fingernails/toes with every meph session.

Ya think maybe you should stop???
Just an idea.....

[dadrone]

Just as an update (I kind of wandered away from this forum after my rabbit's meph disaster)... My neuropathy has indeed improved.

And yes, you can move your foot upwards towards your body. There's a slight movement like this whenever you walk; you naturally lift your foot a bit off the ground so you don't drag it across the floor. (I'm not making this up, look up foot drop) My rabbit absolutely could not move his foot upward, at all, for about three weeks following the incident, making him walk like 50 Cent. He had a dim hope he would improve after discovering that he could at least move his foot upward enough to drive. On the day after the incident, even this was impossible.

It may well have been ischaemia, as was stated above. At first, it was merely numb, but a few weeks later, it began to hurt intensely.

SWIM is not convinced that the effects were entirely vasoconstriction-induced, however. He is skeptical that mephedrone is more vasoconstrictive than propylhexedrine. My rabbit has done the latter several times, and has sat in odd, potentially circulation-restricting positions for far longer than he did when on mephedrone, and has had no ill effects.

My rabbit is a bit concerned (though he wishes he had thought of this BEFORE trying mephedrone) that mephedrone is similar in structure to 4-methylamphetamine, which is rumored to be rather neuro- or cardiotoxic. The ketone functionality of mephedrone should lessen the toxicity somewhat but my rabbit is a bit suspicious, now, of any phenethylamine/amphetamine bearing an alkyl substituent at the 4-position. For that matter, my rabbit wonders about the safety of many research chemicals.

4-MTA (4-methylthioamphetamine) has been known to cause dangerous, organ-destroying hyperthermia due to potentially being an MAOI. 2C-T-7 has also been associated with reported deaths, perhaps due to the same property. It's a bit of a leap, mentally, but my rabbit wonders about the safety of 2C-E and 2C-D due to their bearing an alkyl substituent at the 4-position. My rabbit is inexperienced with 2C-D but remembers feeling pretty nasty after large doses of 2C-E.

SWIM isn't trying to tell anyone what to do, he just thinks the information should be out there.

Reputation Comments on this post:

lots of info in this post, you seem to have done your research and know your stuff

[holdout]

rb10101!!! those are almost exactly the same symptoms i mentionedn other forums about SWIM.... the tinnitus is expected and will go away in a couple months after SWIY quits stimulants.

but yea, SWIM now gets left-scalp numbness after any stimulant session be it mephedrone or methylone or butylone etc... at least the flash headaches went away. SWIM believes the vasoconstritin blocks bloodflow through a small/sensitive vein of the scalp.

[mictihtoya]

Go see a doctor. Please.

[Blizzard777]

Originally Posted by rb10101

Swim uses a European vendor as well. Swim did not detect any foreign contents (primitive analysis - look/touch/smell/taste). In fact, swim believes the typical odor to be of a higher intensity.

Additional notes on the sensation provided by swim:

Starting mid-left ear, a line is traced upwards by 4 inches, connects forward and down to the left eyebrows, circling down and under the eye and the straigh back to the starting point.

The skin feels as if were slightly (very) swollen and has the appears as such. if rubbed, all goes away for 10-20 seconds but returns. The skin flushes slightly, similar to the ears when blood pressure is elevated.

Curious, indeed.

Originally Posted by holdout

rb10101!!! those are almost exactly the same symptoms i mentionedn other forums about SWIM.... the tinnitus is expected and will go away in a couple months after SWIY quits stimulants.

but yea, SWIM now gets left-scalp numbness after any stimulant session be it mephedrone or methylone or butylone etc... at least the flash headaches went away. SWIM believes the vasoconstritin blocks bloodflow through a small/sensitive vein of the scalp.

Seriously Swim sees two Swiy's that would greatly benefit from a visit to the doctor!